Nickel penetration into stratum corneum in FLG null carriers—A human experimental study

Background The filaggrin gene (FLG) plays a role in skin diseases, with the skin barrier function being impaired in FLG null carriers. The role of FLG status in relation to nickel penetration into the skin remains unclear. Objectives To elucidate the association between FLG status and nickel penetra...

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Bibliographic Details
Published in:	Contact dermatitis Vol. 87; no. 2; pp. 154 - 161
Main Authors:	Julander, Anneli, Liljedahl, Emelie Rietz, Korres de Paula, Helena, Assarsson, Eva, Engfeldt, Malin, Littorin, Margareta, Shobana Anto, Christine, Lidén, Carola, Broberg, Karin
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-08-2022 Wiley Subscription Services, Inc
Subjects:	Arbetsmedicin och miljömedicin Clinical Medicine dermal exposure Dermatologi och venereologi Dermatology and Venereal Diseases Environmental Health and Occupational Health Filaggrin FLG status genetic susceptibility Health Sciences human exposure study Hälsovetenskap Klinisk medicin Mass spectroscopy Medical and Health Sciences Medicin och hälsovetenskap Nickel nickel penetration respiratory symptoms Skin diseases skin symptoms Statistical analysis Stratum corneum Nickel penetration; dermal exposure respiratory symptoms skin symptoms genetic susceptibility human exposure study FLG status
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Summary:	Background The filaggrin gene (FLG) plays a role in skin diseases, with the skin barrier function being impaired in FLG null carriers. The role of FLG status in relation to nickel penetration into the skin remains unclear. Objectives To elucidate the association between FLG status and nickel penetration into stratum corneum (SC) in individuals without self‐reported history of nickel allergy. Methods Forty participants (23 FLG wt and 17 FLG null) were exposed to a nickel solution (80 μg/cm2) which was applied onto 2 × 2 cm on their left forearm. After 4 h, the area was tape‐stripped with 10 consecutive tapes. Nickel in each tape was quantified using inductively coupled plasma mass spectrometry. Results The average recovered nickel dose was 35%–48%. A tendency towards lower recovery was seen in FLG null carriers compared to FLG wt carriers, and lower recovery in those with history of skin and/or respiratory symptoms compared to those without such history. This was however not statistically significant. Conclusion FLG null carriers had less nickel recovered by tape strips compared with FLG wt carriers and, compared with individuals without a history of skin and/or respiratory symptoms, indicating higher nickel penetration into SC for FLG null carriers, but further studies are needed. Highlights The role of FLG mutations in relation to nickel penetration into skin is unclear. Twenty‐three FLG wild‐type and 17 FLG null mutation carriers were exposed to 80 μg Ni2+ on a 4 cm2 area on the lower arm for 4 h. Non‐significantly less nickel was recovered from the FLG null compared to the FLG wild‐type carriers, indicating a higher uptake of nickel in FLG null carriers.
Bibliography:	Funding information Forskningsrådet om Hälsa, Arbetsliv och Välfärd, Grant/Award Number: 2016‐00700_FORTE; Medicinska Fakulteten, Lunds Universitet; Naturvårdsverket; Region Skåne; Karolinska Institutet; Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning; Swedish Environmental Protection Agency; Swedish Research Council for Health, Working Life and Welfare ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0105-1873 1600-0536 1600-0536
DOI:	10.1111/cod.14137