Premorbid behavioral and intellectual functioning in schizophrenia patients with poor response to treatment with antipsychotic drugs

Premorbid behavioral and intellectual functioning in schizophrenia patients with poor response to treatment with antipsychotic drugs

Abstract Introduction: Approximately one third of schizophrenia patients show partial or no response to pharmacotherapy. Despite intensive investigations, the phenomenological and biological characteristics of such patients are far from elucidated. This study examined the premorbid behavioral and in...

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Published in:Schizophrenia research Vol. 94; no. 1; pp. 45 - 49
Main Authors: Caspi, Asaf, Reichenberg, Abraham, Weiser, Mark, Rabinowitz, Jonathan, Shmushkevich, Motti, Lubin, Gad, Nahon, Daniella, Vishne, Tali, Davidson, Michael
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 01-08-2007
Elsevier Science
Subjects:
Adult
Adult and adolescent clinical studies
Antipsychotic Agents - therapeutic use
Biological and medical sciences
Clozapine - therapeutic use
Cognition Disorders - diagnosis
Cognition Disorders - epidemiology
Drug Resistance
Female
Humans
Male
Medical sciences
Mental Disorders - diagnosis
Mental Disorders - epidemiology
Neuropharmacology
Neuropsychological Tests
Pharmacology. Drug treatments
Psychiatry
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Psychoses
Registries
Schizophrenia
Schizophrenia - drug therapy
Schizophrenia - epidemiology
Social Behavior
Psychosis
Human
Chemotherapy
Treatment
Neuroleptic
Psychotropic
Schizophrenia
Antipsychotic
Cognition
Intellectual ability
Behavior
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Summary:Abstract Introduction: Approximately one third of schizophrenia patients show partial or no response to pharmacotherapy. Despite intensive investigations, the phenomenological and biological characteristics of such patients are far from elucidated. This study examined the premorbid behavioral and intellectual functioning of schizophrenia patients who showed poor response to antipsychotic treatment. Method: One hundred twenty-nine schizophrenia patients who showed poor response to treatment were ascertained from a national register and matched by gender, age and education to 129 patients who showed adequate response. The groups were compared on premorbid measures of behavioral and intellectual functions. Results: As a group, treatment-resistant male patients had significantly lower (worse) social functioning [ p = 0.002], and individual autonomy [ p < 0.0001] scores before the onset of the illness compared to treatment non-resistant patients. Male and female treatment-resistant patients did not differ from non-resistant patients in premorbid intellectual functioning [ p > 0.1]. Conclusions: Low premorbid social functioning and individual autonomy, but not intellectual functioning, could serve as predictors of poor treatment response in schizophrenia.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2007.04.007