Search Results - "Shkedi, Arielle"

A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities by Shao, Hao, Taguwa, Shuhei, Gilbert, Luke, Shkedi, Arielle, Sannino, Sara, Guerriero, Christopher J, Gale-Day, Zachary J, Young, Zapporah T, Brodsky, Jeffrey L, Weissman, Jonathan, Gestwicki, Jason E, Frydman, Judith

“…The potential of small molecules to localize within subcellular compartments is rarely explored. To probe this question, we measured the localization of Hsp70…”
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KRAS G12C inhibition produces a driver-limited state revealing collateral dependencies by Lou, Kevin, Steri, Veronica, Ge, Alex Y, Hwang, Y Christina, Yogodzinski, Christopher H, Shkedi, Arielle R, Choi, Alex L M, Mitchell, Dominique C, Swaney, Danielle L, Hann, Byron, Gordan, John D, Shokat, Kevan M, Gilbert, Luke A

“…Inhibitors targeting KRAS , a mutant form of the guanosine triphosphatase (GTPase) KRAS, are a promising new class of oncogene-specific therapeutics for the…”
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The interactions of molecular chaperones with client proteins: why are they so weak? by Arhar, Taylor, Shkedi, Arielle, Nadel, Cory M., Gestwicki, Jason E.

“…The major classes of molecular chaperones have highly variable sequences, sizes, and shapes, yet they all bind to unfolded proteins, limit their aggregation,…”
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Chemical and Genetic Perturbations Reveal Wiring of the Protein Homeostasis Network in Prostate Cancer by Shkedi, Arielle

“…The protein homeostasis (proteostasis) network is composed of multiple components and pathways that work together to govern protein production, folding,…”
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Inhibitor Combinations Reveal Wiring of the Proteostasis Network in Prostate Cancer Cells by Shkedi, Arielle, Adkisson, Michael, Schroeder, Andrew, Eckalbar, Walter L, Kuo, Szu-Yu, Neckers, Leonard, Gestwicki, Jason E

“…The protein homeostasis (proteostasis) network is composed of multiple pathways that work together to balance protein folding, stability, and turnover. Cancer…”
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Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer by Shkedi, Arielle, Taylor, Isabelle R, Echtenkamp, Frank, Ramkumar, Poornima, Alshalalfa, Mohamed, Rivera-Márquez, Génesis M, Moses, Michael A, Shao, Hao, Karnes, Robert Jeffrey, Neckers, Len, Feng, Felix, Kampmann, Martin, Gestwicki, Jason E

“…Castration-resistant prostate cancer (CRPC) is associated with an increased reliance on heat shock protein 70 (HSP70), but it is not clear what other protein…”
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