Search Results - "Shizuru, J"

Tolerance and Withdrawal of Immunosuppressive Drugs in Patients Given Kidney and Hematopoietic Cell Transplants by Scandling, J. D., Busque, S., Dejbakhsh‐Jones, S., Benike, C., Sarwal, M., Millan, M. T., Shizuru, J. A., Lowsky, R., Engleman, E. G., Strober, S.

“…Sixteen patients conditioned with total lymphoid irradiation (TLI) and antithymocyte globulin (ATG) were given kidney transplants and an injection of CD34+…”
Get full text

Chimerism, Graft Survival, and Withdrawal of Immunosuppressive Drugs in HLA Matched and Mismatched Patients After Living Donor Kidney and Hematopoietic Cell Transplantation by Scandling, J. D., Busque, S., Shizuru, J. A., Lowsky, R., Hoppe, R., Dejbakhsh‐Jones, S., Jensen, K., Shori, A., Strober, J. A., Lavori, P., Turnbull, B. B., Engleman, E. G., Strober, S.

“…Thirty‐eight HLA matched and mismatched patients given combined living donor kidney and enriched CD34+ hematopoietic cell transplants were enrolled in…”
Get full text

Complementing mutations in core binding factor leukemias: from mouse models to clinical applications by Müller, A M S, Duque, J, Shizuru, J A, Lübbert, M

“…A great proportion of acute myeloid leukemias (AMLs) display cytogenetic abnormalities including chromosomal aberrations and/or submicroscopic mutations. These…”
Get full text

Allogeneic hematopoietic cell transplantation after failed autologous transplant for lymphoma using TLI and anti-thymocyte globulin conditioning by Rezvani, A R, Kanate, A S, Efron, B, Chhabra, S, Kohrt, H E, Shizuru, J A, Laport, G G, Miklos, D B, Benjamin, J E, Johnston, L J, Arai, S, Weng, W-K, Negrin, R S, Strober, S, Lowsky, R

“…We describe 47 patients with lymphoma and failed prior autologous hematopoietic cell transplantation (HCT) who received TLI-ATG (anti-thymocyte globulin)…”
Get full text

Sirolimus and mycophenolate mofetil as GVHD prophylaxis in myeloablative, matched-related donor hematopoietic cell transplantation by Johnston, L, Florek, M, Armstrong, R, McCune, J S, Arai, S, Brown, J, Laport, G, Lowsky, R, Miklos, D, Shizuru, J, Sheehan, K, Lavori, P, Negrin, R

“…We investigated sirolimus and mycophenolate mofetil (MMF) as GVHD prophylaxis in patients with advanced hematological malignancies receiving myeloablative…”
Get full text

Tandem chemo-mobilization followed by high-dose melphalan and carmustine with single autologous hematopoietic cell transplantation for multiple myeloma by Chen, A I, Negrin, R S, McMillan, A, Shizuru, J A, Johnston, L J, Lowsky, R, Miklos, D B, Arai, S, Weng, W-K, Laport, G G, Stockerl-Goldstein, K

“…Single autologous hematopoietic cell transplant (AHCT) with high-dose melphalan prolongs survival in patients with multiple myeloma but is not curative. We…”
Get full text

Allogeneic hematopoietic cell transplant for normal karyotype AML: indirect evidence of selection for adverse molecular profile by Percival, M-E M, Medeiros, B C, Tian, L, Robeson, S, Laport, G G, Johnston, L J, Shizuru, J A, Miklos, D B, Arai, S, Weng, W-K, Negrin, R S, Lowsky, R

Get full text

B6.g7 mice reconstituted with BDC2·5 non‐obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes by Rajasekaran, N., Wang, N., Hang, Y., Macaubas, C., Rinderknecht, C., Beilhack, G. F., Shizuru, J. A., Mellins, E. D.

“…Summary In BDC2·5 non‐obese diabetic (BDC2·5NOD) mice, a spontaneous model of type 1 diabetes, CD4+ T cells express a transgene‐encoded T cell receptor (TCR)…”
Get full text

Long-term follow-up of patients with diffuse large B-cell non-Hodgkin's lymphoma receiving purged autografts after induction failure by Benjamin, J E, Chen, G L, Cao, T M, Cao, P D, Wong, R M, Sheehan, K, Shizuru, J A, Johnston, L J, Negrin, R S, Lowsky, R, Laport, G G

“…Patients with diffuse large B-cell lymphoma (DLBCL) who do not achieve a complete response to front-line combination chemotherapy are often offered high-dose…”
Get full text

Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects by McSweeney, Peter A., Niederwieser, Dietger, Shizuru, Judith A., Sandmaier, Brenda M., Molina, Arthur J., Maloney, David G., Chauncey, Thomas R., Gooley, Theodore A., Hegenbart, Ute, Nash, Richard A., Radich, Jerald, Wagner, John L., Minor, Steven, Appelbaum, Frederick R., Bensinger, William I., Bryant, Eileen, Flowers, Mary E.D., Georges, George E., Grumet, F. Carl, Kiem, Hans-Peter, Torok-Storb, Beverly, Yu, Cong, Blume, Karl G., Storb, Rainer F.

“…Toxicities have limited the use of allogeneic hematopoietic cell transplantation (HCT) to younger, medically fit patients. In a canine HCT model, a combination…”
Get full text

Long-term outcomes in patients with high-risk myeloid malignancies following matched related donor hematopoietic cell transplantation with myeloablative conditioning of BU, etoposide and CY by Naik, S, Wong, R, Arai, S, Brown, J, Laport, G, Lowsky, R, Miklos, D, Shizuru, J, Blume, K, Negrin, R, Johnston, L

“…Patients with high-risk or advanced myeloid malignancies have limited effective treatment options. These include high-dose therapy followed by allogeneic…”
Get full text

European LeukemiaNet classification intermediate risk-1 cohort is associated with poor outcomes in adults with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation by Medeiros, B C, Tian, L, Robenson, S, Laport, G G, Johnston, L J, Shizuru, J A, Miklos, D B, Arai, S, Benjamin, J E, Weng, W-K, Negrin, R S, Lowsky, R

Get full text

Hematopoietic cell transplantation from HLA-identical sibling donors after low-dose radiation-based conditioning for treatment of CML by KERBAUY, F. R, STORB, R, EPNER, E. M, CHAUNCEY, T. R, BLUME, K. G, NIEDERWIESER, D, SANDMAIER, B. M, HEGENBART, U, GOOLEY, T, SHIZURU, J, AL-ALI, H. K, RADICH, J. P, MALONEY, D. G, AGURA, E, BRUNO, B

“…A total of 24 patients (median age 58; range, 27-71 years) with chronic myeloid leukemia (CML) in first chronic (CP1) (n=14), second chronic (n=4), or…”
Get full text

Expansion of cytolytic CD8+ natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon γ production by Baker, Jeanette, Verneris, Michael R., Ito, Maki, Shizuru, Judith A., Negrin, Robert S.

“…T cells with natural killer cell phenotype and function (NKT cells) have been described in both human and murine tissues. In this study, culture conditions…”
Get full text

Effect of Oral Glutamine Supplementation During Bone Marrow Transplantation by Coghlin Dickson, Tara M., Wong, Ruby M., Negrin, Robert S., Shizuru, Judith A., Johnston, Laura J., Hu, Wendy W., Blume, Karl G., Stockerl-Goldstein, Keith E.

“…Background: Because all patients receiving bone marrow transplant (BMT) and peripheral blood progenitor cell transplant (PBPCT) experience gastrointestinal…”
Get full text

Toward Regenerative Medicine by Lagasse, Eric, Shizuru, Judith A., Uchida, Nobuko, Tsukamoto, Ann, Weissman, Irving L.

“…Much of medicine practiced today involves the use of small molecules to intervene in a disease process; following elimination of the lesion, we expect the body…”
Get full text

Immunotherapy of the Nonobese Diabetic Mouse: Treatment with an Antibody to T-Helper Lymphocytes by Shizuru, Judith A., Taylor-Edwards, Cariel, Banks, Beth Ann, Gregory, Anita K., Fathman, C. Garrison

“…Spontaneous diabetes mellitus was blocked in nonobese diabetic mice by treatment with a monoclonal antibody against the L3T4 determinant present on the surface…”
Get full text

Purified Hematopoietic Stem Cell Grafts Induce Tolerance to Alloantigens and Can Mediate Positive and Negative T Cell Selection by Shizuru, Judith A., Weissman, Irving L., Kernoff, Rachel, Masek, Marilyn, Scheffold, Yolanda C.

“…Engraftment of allogeneic bone marrow (BM) has been shown to induce tolerance to organs genotypically matched with the BM donor. Immune reconstitution after BM…”
Get full text

Anti-CD4 mediates clonal anergy during transplantation tolerance induction by ALTERS, S. E, SHIZURU, J. A, ACKERMAN, J, GROSSMAN, D, SEYDEL, K. B, FATHMAN, C. G

“…Depletion of CD4+ cells using anti-CD4 monoclonal antibodies leads to allograft tolerance. Here we show that anti-CD4-mediated tolerance to pancreatic islets…”
Get full text

Islet Allograft Survival after a Single Course of Treatment of Recipient with Antibody to L3T4 by Shizuru, Judith A., Gregory, Anita K., Chao, C. Tien-Bao, Fathman, C. Garrison

“…Allografts of pancreatic islets of Langerhans were induced to survive for an indefinite period in diabetic mice if, at the time of engraftment, the mice…”
Get full text