Search Results - "Shizuka, Manami"

A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs) by Miller, Michael L, Shizuka, Manami, Wilhelm, Alan, Salomon, Paulin, Reid, Emily E, Lanieri, Leanne, Sikka, Surina, Maloney, Erin K, Harvey, Lauren, Qiu, Qifeng, Archer, Katie E, Bai, Chen, Vitharana, Dilrukshi, Harris, Luke, Singh, Rajeeva, Ponte, Jose F, Yoder, Nicholas C, Kovtun, Yelena, Lai, Katharine C, Ab, Olga, Pinkas, Jan, Keating, Thomas A, Chari, Ravi V J

“…Tumor-selective delivery of cytotoxic agents in the form of antibody-drug conjugates (ADCs) is now a clinically validated approach for cancer treatment. In an…”
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Catalytic Enantioselective Hosomi-Sakurai Conjugate Allylation of Cyclic Unsaturated Ketoesters by Shizuka, Manami, Snapper, Marc L

“…No fancy catalyst required: The copper‐catalyzed enantioselective conjugate allylation of activated cyclic enones affords products in up to >98 % ee. Reactions…”
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Catalytic Enantioselective Hosomi-Sakurai Conjugate Allylation of Cyclic Unsaturated Ketoesters by Shizuka, Manami, Snapper, Marc L.

“…Mit käuflichem Katalysator: Die kupferkatalysierte enantioselektive konjugierte Allylierung von aktivierten cyclischen Enonen ergibt die Produkte mit teilweise…”
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Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody–Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation by Bai, Chen, Reid, Emily E, Wilhelm, Alan, Shizuka, Manami, Maloney, Erin K, Laleau, Rassol, Harvey, Lauren, Archer, Katie E, Vitharana, Dilrukshi, Adams, Sharlene, Kovtun, Yelena, Miller, Michael L, Chari, Ravi, Keating, Thomas A, Yoder, Nicholas C

“…Antibody–drug conjugates have elicited great interest recently as targeted chemotherapies for cancer. Recent preclinical and clinical data have continued to…”
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Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction by Reutershan, Michael H, Machacek, Michelle R, Altman, Michael D, Bogen, Stephane, Cai, Mingmei, Cammarano, Carolyn, Chen, Dapeng, Christopher, Matthew, Cryan, John, Daublain, Pierre, Fradera, Xavier, Geda, Prasanthi, Goldenblatt, Peter, Hill, Armetta D, Kemper, Raymond A, Kutilek, Victoria, Li, Chaomin, Martinez, Michelle, McCoy, Mark, Nair, Latha, Pan, Weidong, Thompson, Christopher F, Scapin, Giovanna, Shizuka, Manami, Spatz, Marianne L, Steinhuebel, Dietrich, Sun, Binyuan, Voss, Matthew E, Wang, Xiao, Yang, Liping, Yeh, Tammie C, Dussault, Isabelle, Marshall, C. Gary, Trotter, B. Wesley

“…Identification of low-dose, low-molecular-weight, drug-like inhibitors of protein–protein interactions (PPIs) is a challenging area of research. Despite the…”
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Abstract 75: Comparison of site-specific and lysine-linked indolino-benzodiazepine antibody-drug conjugates (ADCs) by Bai, Chen, Yoder, Nicholas C., Wilhelm, Alan, Adams, Sharlene, Whiteman, Kathleen, Lee, Jenny, O'Callaghan, Katie, Maloney, Erin, Shizuka, Manami, Kovtun, Yelena, Keating, Thomas A.

“…Abstract ADCs are a promising modality for cancer therapy enabled by chemical conjugation of potent cytotoxic compounds to monoclonal antibodies. While many…”
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Abstract 747: A new class of DNA alkylating indolino-benzodiazepine agents (BIAs) linked with a DNA binding moiety for use with antibody-drug conjugates (ADCs) by Miller, Michael L., Reid, Emily E., Archer, Katie E., Shizuka, Manami, McShea, Molly A., Maloney, Erin K., Ab, Olga, Lanieri, Leanne, Wilhelm, Alan J., Ponte, Jose F., Yoder, Nicholas C., Chari, Ravi V.

“…Abstract We have previously disclosed antibody-drug conjugates (ADCs) that incorporate our highly potent novel DNA alkylating indolino-benzodiazepine (termed…”
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Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs) by Reid, Emily E., Archer, Katie E., Shizuka, Manami, McShea, Molly A., Maloney, Erin K., Ab, Olga, Lanieri, Leanne, Wilhelm, Alan, Ponte, Jose F., Yoder, Nicholas C., Chari, Ravi V.J., Miller, Michael L.

“…[Display omitted] Antibody-drug conjugates (ADCs) incorporating potent indolinobenzodiazepine (IGN) DNA alkylators as the cytotoxic payload are currently…”
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Abstract 2965: In vitro and in vivo activity of a site-specific SeriMab antibody-drug conjugate (ADC) using an indolino-benzodiazepine DNA-alkylating agent by Vitharana, Dilrukshi, Wilhelm, Alan, Harris, Luke, Archer, Katie, Shizuka, Manami, Maloney, Erin, Ab, Olga, Laleau, Rassol, Sun, Xiuxia, Pinkas, Jan, Miller, Michael, Chari, Ravi, Keating, Thomas, Fishkin, Nathan

“…Abstract Previously we have described the characterization of a proprietary class of indolino-benzodiazepine dimers, IGNs, with high potency against many…”
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Abstract 53: Antibody-drug conjugates (ADCs) of peptide-linked Indolino-Benzodiazepine (IGN) DNA-alkylator provides improved anti-tumor activity over that of a crosslinker by Miller, Michael L., Shizuka, Manami, Ponte, Jose F., Lanieri, Leanne, Vitharana, Dilrukshi, Qiu, Qifeng, Reid, Emily E., Archer, Katie E., Wu, Rui, Maloney, Erin K., Ab, Olga, Pinkas, Jan, Chari, Ravi V.

“…Abstract We recently disclosed highly active antibody-drug conjugates (ADCs) that incorporated the novel DNA alkylating indolino-benzodiazepine (termed IGN)…”
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Abstract 2960: Potent in vivo activity of site-specific indolino-benzodiazepine antibody-drug conjugates (ADCs) generated via engineered cysteine conjugation by Yoder, Nicholas C., Bai, Chen, Wilhelm, Alan, Maloney, Erin K., Ab, Olga, Reid, Emily E., Shizuka, Manami, Tavares, Daniel, Laleau, Rassol, Sun, Xiuxia, Bogalhas, Megan E., Wang, Lintao, Pinkas, Jan, Miller, Michael L., Chari, Ravi, Keating, Thomas A.

“…Abstract ADCs are widely studied for cancer therapy, with numerous agents in preclinical and clinical development embodying a wide array of targets, linker…”
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Synthesis of Highly Potent N‑10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody–Drug Conjugates (ADCs) by Archer, Katie E, Reid, Emily E, Shizuka, Manami, Woods, James, Harris, Luke, Maloney, Erin K, Bartle, Laura M, Ab, Olga, Wilhelm, Alan, Setiady, Yulius, Ponte, Jose F, Singh, Rajeeva, Keating, Thomas A, Chari, Ravi V. J, Miller, Michael L

“…Indolinobenzodiazepine DNA alkylators (IGNs) are the cytotoxic payloads in antibody–drug conjugates (ADCs) currently undergoing Phase I clinical evaluation…”
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Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody–Drug Conjugates (ADCs) by Reid, Emily E, Archer, Katie E, Shizuka, Manami, Wilhelm, Alan, Yoder, Nicholas C, Bai, Chen, Fishkin, Nathan E, Harris, Luke, Maloney, Erin K, Salomon, Paulin, Hong, Erica, Wu, Rui, Ab, Olga, Jin, Shan, Lai, Katharine C, Sikka, Surina, Chari, Ravi V. J, Miller, Michael L

“…Antibody–drug conjugates (ADCs) that incorporate potent indolinobenzodiazepine DNA alkylators as the payload component are currently undergoing clinical…”
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Abstract 652: Antibody-drug conjugates (ADCs) of indolino-benzodiazepine DNA-alkylating agents by Miller, Michael L., Shizuka, Manami, Fishkin, Nathan, Reid, Emily, Archer, Katie, Maloney, Erin, Bai, Chen, Ab, Olga, Yoder, Nick C., Wu, Rui, Hong, Erica, Bogalhas, Megan, Wilhelm, Alan, Whiteman, Kathleen, Chari, Ravi

“…Abstract There are over thirty ADCs in the clinic today, reflecting the interest in ADCs for the treatment of cancer. Most of these ADCs utilize a…”
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Abstract 2959: Peptide-linked indolino-benzodiazepine DNA-alkylating agents for use in antibody-drug conjugates (ADCs) by Shizuka, Manami, Wilhelm, Alan, Archer, Katie, Reid, Emily, Yoder, Nicholas C., Bai, Chen, Fishkin, Nathan, Harris, Luke, Maloney, Erin, Hong, Erica, Wu, Rui, Ab, Olga, Lai, Kate, Sikka, Surina, Jin, Shan, Pinkas, Jan, Chari, Ravi, Miller, Michael L.

“…Abstract As part of our efforts to expand the available toolbox of cytotoxic payloads for use in antibody-drug conjugates (ADCs), we have recently described…”
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Abstract 647: SeriMabs: N-terminal serine modification enables modular, site-specific payload incorporation into antibody-drug conjugates (ADCs) by Harris, Luke, Tavares, Daniel, Rui, Lingyun, Maloney, Erin, Wilhelm, Alan, Costoplus, Juliet, Archer, Katie, Bogalhas, Megan, Harvey, Lauren, Wu, Rui, Chen, Xuan, Xu, Xiangyang, Connaughton, Sonia, Wang, Lintao, Whiteman, Kathleen, Ab, Olga, Hong, Erica, Widdison, Wayne, Shizuka, Manami, Miller, Michael, Pinkas, Jan, Keating, Thomas, Chari, Ravi, Fishkin, Nathan

“…Abstract Site-specific incorporation of cell-killing agents into cancer-targeting antibodies is an active area of innovation in the field of ADCs. We have…”
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Synthesis of Isoprostanyl Phosphatidylcholine and Isoprostanyl Phosphatidylethanolamine by Shizuka, Manami, Schrader, Thomas O, Snapper, Marc L

“…The syntheses of two isoprostanyl phospholipids are described. A newly established route to 15-F2t-isoprostane and ent-15-epi-F2t-isoprostane has allowed for…”
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Total synthesis of ent-15-epi-F2t-isoprostane and derivatives and the development of the first catalytic enantioselective Hosomi-Sakurai conjugate allylation by Shizuka, Manami

“…Chapter 1: Catalytic enantioselective allylations of carbonyl compounds. The first chapter will be a review of methods for catalytic enantioselective…”
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Total synthesis of ent-15-epi-F2t-isoprostane and derivatives and the development of the first catalytic enantioselective Hosomi-Sakurai conjugate allylation by Shizuka, Manami

“…Chapter 1: Catalytic enantioselective allylations of carbonyl compounds. The first chapter will be a review of methods for catalytic enantioselective…”
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Catalytic Enantioselective Hosomi–Sakurai Conjugate Allylation of Cyclic Unsaturated Ketoesters by Shizuka, Manami, Snapper, Marc L.

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