Search Results - "Shizgal, Peter"

The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle by Pallikaras, Vasilios, Shizgal, Peter

“…Deep-brain stimulation of the medial forebrain bundle (MFB) can provide effective, enduring relief of treatment-resistant depression. Panksepp provided an…”
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Dopamine neurons do not constitute an obligatory stage in the final common path for the evaluation and pursuit of brain stimulation reward by Trujillo-Pisanty, Ivan, Conover, Kent, Solis, Pavel, Palacios, Daniel, Shizgal, Peter, Dominguez, Juan M

“…The neurobiological study of reward was launched by the discovery of intracranial self-stimulation (ICSS). Subsequent investigation of this phenomenon provided…”
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Dopamine and Beyond: Implications of Psychophysical Studies of Intracranial Self-Stimulation for the Treatment of Depression by Pallikaras, Vasilios, Shizgal, Peter

“…Major depressive disorder is a leading cause of disability and suicide worldwide. Consecutive rounds of conventional interventions are ineffective in a…”
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Valuation of opportunity costs by rats working for rewarding electrical brain stimulation by Solomon, Rebecca Brana, Conover, Kent, Shizgal, Peter

“…Pursuit of one goal typically precludes simultaneous pursuit of another. Thus, each exclusive activity entails an "opportunity cost:" the forgone benefits from…”
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Functional Imaging of Neural Responses to Expectancy and Experience of Monetary Gains and Losses by Breiter, Hans C., Aharon, Itzhak, Kahneman, Daniel, Dale, Anders, Shizgal, Peter

“…Neural responses accompanying anticipation and experience of monetary gains and losses were monitored by functional magnetic resonance imaging. Trials…”
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At what stage of neural processing does cocaine act to boost pursuit of rewards? by Hernandez, Giovanni, Breton, Yannick-André, Conover, Kent, Shizgal, Peter

“…Dopamine-containing neurons have been implicated in reward and decision making. One element of the supporting evidence is that cocaine, like other drugs that…”
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Some work and some play: microscopic and macroscopic approaches to labor and leisure by Niyogi, Ritwik K, Shizgal, Peter, Dayan, Peter

“…Given the option, humans and other animals elect to distribute their time between work and leisure, rather than choosing all of one and none of the other…”
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Modulation of Brain Reward Circuitry by Leptin by Fulton, Stephanie, Woodside, Barbara, Shizgal, Peter

“…Leptin, a hormone secreted by fat cells, suppresses food intake and promotes weight loss. To assess the action of this hormone on brain reward circuitry,…”
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Learning to use past evidence in a sophisticated world model by Ahilan, Sanjeevan, Solomon, Rebecca B, Breton, Yannick-André, Conover, Kent, Niyogi, Ritwik K, Shizgal, Peter, Dayan, Peter

“…Humans and other animals are able to discover underlying statistical structure in their environments and exploit it to achieve efficient and effective…”
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The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations by Scardochio, Tina, Trujillo-Pisanty, Ivan, Conover, Kent, Shizgal, Peter, Clarke, Paul B S

“…Adult rats emit ultrasonic vocalizations (USVs) at around 50-kHz; these commonly occur in contexts that putatively engender positive affect. While several…”
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Ventral Midbrain NMDA Receptor Blockade: From Enhanced Reward and Dopamine Inactivation by Hernandez, Giovanni, Cossette, Marie-Pierre, Shizgal, Peter, Rompré, Pierre-Paul

“…Glutamate stimulates ventral midbrain (VM) N-Methyl-D-Aspartate receptors (NMDAR) to initiate dopamine (DA) burst firing activity, a mode of discharge…”
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Robust optical fiber patch-cords for in vivo optogenetic experiments in rats by Trujillo-Pisanty, Ivan, Sanio, Christian, Chaudhri, Nadia, Shizgal, Peter

“…[Display omitted] In vivo optogenetic experiments commonly employ long lengths of optical fiber to connect the light source (commonly a laser) to the optical…”
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The trade-off between pulse duration and power in optical excitation of midbrain dopamine neurons approximates Bloch’s law by Pallikaras, Vasilios, Carter, Francis, Velazquez-Martinez, David Natanael, Arvanitogiannis, Andreas, Shizgal, Peter

“…Optogenetic experiments reveal functional roles of specific neurons. However, functional inferences have been limited by widespread adoption of a restricted…”
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The priming effect of rewarding brain stimulation in rats depends on both the cost and strength of reward but survives blockade of D2‐like dopamine receptors by Evangelista, Czarina, Mehrez, Norhan, Boisvert, Esthelle Ewusi, Brake, Wayne G., Shizgal, Peter

“…Receipt of an intense reward boosts motivation to work for more of that reward. This phenomenon is called the priming effect of rewards . Using a novel…”
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17β-estradiol locally increases phasic dopamine release in the dorsal striatum by Shams, Waqqas M., Cossette, Marie-Pierre, Shizgal, Peter, Brake, Wayne G.

“…•17β-estradiol has been shown to increase dopamine release in the dorsal striatum.•It is not known if 17β-estradiol affects tonic and/or phasic dopamine…”
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Corrigendum: Validation and extension of the reward-mountain model by Shizgal, Peter

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Does phasic dopamine release cause policy updates? by Carter, Francis, Cossette, Marie‐Pierre, Trujillo‐Pisanty, Ivan, Pallikaras, Vasilios, Breton, Yannick‐André, Conover, Kent, Caplan, Jill, Solis, Pavel, Voisard, Jacques, Yaksich, Alexandra, Shizgal, Peter

“…Phasic dopamine activity is believed to both encode reward‐prediction errors (RPEs) and to cause the adaptations that these errors engender. If so, a rat…”
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Scarce means with alternative uses: robbins' definition of economics and its extension to the behavioral and neurobiological study of animal decision making by Shizgal, Peter

“…Almost 80 years ago, Lionel Robbins proposed a highly influential definition of the subject matter of economics: the allocation of scarce means that have…”
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Some Work and Some Play: Microscopic and Macroscopic Approaches to Labor and Leisure: e1003894 by Niyogi, Ritwik K, Shizgal, Peter, Dayan, Peter

“…Given the option, humans and other animals elect to distribute their time between work and leisure, rather than choosing all of one and none of the other…”
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Role of dopamine tone in the pursuit of brain stimulation reward by Hernandez, Giovanni, Trujillo-Pisanty, Ivan, Cossette, Marie-Pierre, Conover, Kent, Shizgal, Peter

“…Dopaminergic neurons contribute to intracranial self-stimulation (ICSS) and other reward-seeking behaviors, but it is not yet known where dopaminergic neurons…”
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