Search Results - "Shivnaraine, Rabindra V"

SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant by Guo, Hongchao, Yu, Xuan, Liu, Yu, Paik, David T, Justesen, Johanne Marie, Chandy, Mark, Jahng, James W S, Zhang, Tiejun, Wu, Weijun, Rwere, Freeborn, Zhao, Shane Rui, Pokhrel, Suman, Shivnaraine, Rabindra V, Mukherjee, Souhrid, Simon, Daniel J, Manhas, Amit, Zhang, Angela, Chen, Che-Hong, Rivas, Manuel A, Gross, Eric R, Mochly-Rosen, Daria, Wu, Joseph C

“…The common aldehyde dehydrogenase 2 ( ) alcohol flushing variant known as affects ∼8% of the world's population. Even in heterozygous carriers, this missense…”
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Ligand-Induced Coupling between Oligomers of the M2 Receptor and the Gi1 Protein in Live Cells by Li, Yuchong, Shivnaraine, Rabindra V., Huang, Fei, Wells, James W., Gradinaru, Claudiu C.

“…Uncertainty over the mechanism of signaling via G protein-coupled receptors (GPCRs) relates in part to questions regarding their supramolecular structure…”
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Allostery of atypical modulators at oligomeric G protein-coupled receptors by Shivnaraine, Rabindra V., Kelly, Brendan, Elmslie, Gwendolynne, Huang, Xi-Ping, Dong, Yue John, Seidenberg, Margaret, Wells, James W., Ellis, John

“…Many G protein-coupled receptors (GPCRs) are therapeutic targets, with most drugs acting at the orthosteric site. Some GPCRs also possess allosteric sites,…”
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Allosteric modulation in monomers and oligomers of a G protein-coupled receptor by Shivnaraine, Rabindra V, Kelly, Brendan, Sankar, Krishana S, Redka, Dar'ya S, Han, Yi Rang, Huang, Fei, Elmslie, Gwendolynne, Pinto, Daniel, Li, Yuchong, Rocheleau, Jonathan V, Gradinaru, Claudiu C, Ellis, John, Wells, James W

“…The M2 muscarinic receptor is the prototypic model of allostery in GPCRs, yet the molecular and the supramolecular determinants of such effects are unknown…”
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FDA Modernization Act 2.0 Paves the Way to Computational Biology and Clinical Trials in a Dish by Ahmed, Syed Mukhtar, Shivnaraine, Rabindra V., Wu, Joseph C.

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Coupling of G Proteins to Reconstituted Monomers and Tetramers of the M2 Muscarinic Receptor by Redka, Dar'ya S., Morizumi, Takefumi, Elmslie, Gwendolynne, Paranthaman, Pranavan, Shivnaraine, Rabindra V., Ellis, John, Ernst, Oliver P., Wells, James W.

“…G protein-coupled receptors can be reconstituted as monomers in nanodiscs and as tetramers in liposomes. When reconstituted with G proteins, both forms enable…”
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Single-Molecule Analysis of the Supramolecular Organization of the M2 Muscarinic Receptor and the Gαi1 Protein by Shivnaraine, Rabindra V, Fernandes, Dennis D, Ji, Huiqiao, Li, Yuchong, Kelly, Brendan, Zhang, Zhenfu, Han, Yi Rang, Huang, Fei, Sankar, Krishana S, Dubins, David N, Rocheleau, Jonathan V, Wells, James W, Gradinaru, Claudiu C

“…G protein-coupled receptors constitute the largest family of transmembrane signaling proteins and the largest pool of drug targets, yet their mechanism of…”
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Heterotropic Cooperativity within and between Protomers of an Oligomeric M2 Muscarinic Receptor by Shivnaraine, Rabindra V, Huang, Xi-Ping, Seidenberg, Margaret, Ellis, John, Wells, James W

“…At least four allosteric sites have been found to mediate the dose-dependent effects of gallamine on the binding of [3H]quinuclidinylbenzilate (QNB) and…”
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ADMET-AI: a machine learning ADMET platform for evaluation of large-scale chemical libraries by Swanson, Kyle, Walther, Parker, Leitz, Jeremy, Mukherjee, Souhrid, Wu, Joseph C, Shivnaraine, Rabindra V, Zou, James

“…The emergence of large chemical repositories and combinatorial chemical spaces, coupled with high-throughput docking and generative AI, have greatly expanded…”
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The M2 Muscarinic Receptor Signaling Complex Resolved by Single Molecule Tracking in Live Cells by Li, Yuchong, Shivnaraine, Rabindra V., Ji, Huiqiao, Huang, Fei, Braeckmans, Kevin, Wells, James W., Gradinaru, Claudiu C.

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Heterotropic Cooperativity within and between Protomers of an Oligomeric M 2 Muscarinic Receptor by Shivnaraine, Rabindra V., Huang, Xi-Ping, Seidenberg, Margaret, Ellis, John, Wells, James W.

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Single-Molecule Analysis of the Supramolecular Organization of the M 2 Muscarinic Receptor and the Gα i1 Protein by Shivnaraine, Rabindra V., Fernandes, Dennis D., Ji, Huiqiao, Li, Yuchong, Kelly, Brendan, Zhang, Zhenfu, Han, Yi Rang, Huang, Fei, Sankar, Krishana S., Dubins, David N., Rocheleau, Jonathan V., Wells, James W., Gradinaru, Claudiu C.

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Nature of the M2 Muscarinic Receptor Signaling Complex Revealed by Dual-Color FCS and FRET by Li, Yuchong, Shivnaraine, Rabindra V., Fernandes, Dennis D., Ji, Huiqiao, Huang, Fei, Wells, James W., Gradinaru, Claudiu C.

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Single-Molecule Study of the Oligomeric States of the M2 Muscarinic Receptor, the Gi1 Protein and the M2-Gi1 Complex by Fernandes, Dennis D., Shivnaraine, Rabindra V., Li, Yuchong, Huiqiao, Ji, Zhang, Zhenfu, Kelly, Brendan, Han, Nellie, Huang, Fei, Sankar, Krishana S., Rocheleau, Jonathon V., Wells, James W., Gradinaru, Claudiu C.

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Ligand-Induced Coupling between Oligomers of the M 2 Receptor and the G i1 Protein in Live Cells by Li, Yuchong, Shivnaraine, Rabindra V, Huang, Fei, Wells, James W, Gradinaru, Claudiu C

“…Uncertainty over the mechanism of signaling via G protein-coupled receptors (GPCRs) relates in part to questions regarding their supramolecular structure…”
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Heterotropic cooperativity within and between protomers of an oligomeric M(2) muscarinic receptor by Shivnaraine, Rabindra V, Huang, Xi-Ping, Seidenberg, Margaret, Ellis, John, Wells, James W

“…At least four allosteric sites have been found to mediate the dose-dependent effects of gallamine on the binding of [(3)H]quinuclidinylbenzilate (QNB) and…”
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ADMET-AI: A machine learning ADMET platform for evaluation of large-scale chemical libraries – Data and Models by Swanson, Kyle, Walther, Parker, Leitz, Jeremy, Mukherjee, Souhrid, Wu, Joseph C., Shivnaraine, Rabindra V., Zou, James

“…This repository contains data and models used in the following paper.   Swanson, K., Walther, P., Leitz, J., Mukherjee, S., Wu, J. C., Shivnaraine, R. V., &…”
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