Search Results - "Shivji, Mahmud K"

BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange by Shivji, Mahmud K.K, Mukund, Shreyas R, Rajendra, Eeson, Chen, Shaoxia, Short, Judith M, Savill, Jane, Klenerman, David, Venkitaraman, Ashok R

“…The breast and ovarian cancer suppressor BRCA2 controls the enzyme RAD51 during homologous DNA recombination (HDR) to preserve genome stability. BRCA2 binds to…”
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Selection of Cervical Keratinocytes Containing Integrated HPV16 Associates with Episome Loss and an Endogenous Antiviral Response by Pett, Mark R., Herdman, M. Trent, Palmer, Roger D., Yeo, Giles S. H., Shivji, Mahmud K., Stanley, Margaret A., Coleman, Nicholas

“…Integration of high-risk human papillomavirus (HRHPV) into the host genome is a key event in cervical neoplastic progression. Integration is associated with…”
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region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange by Shivji, Mahmud K.K, Davies, Owen R, Savill, Jane M, Bates, Debbie L, Pellegrini, Luca, Venkitaraman, Ashok R

“…Human BRCA2, a breast and ovarian cancer suppressor, binds to the DNA recombinase RAD51 through eight conserved BRC repeats, motifs of ~30 residues, dispersed…”
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BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation by Shivji, Mahmud K.K., Renaudin, Xavier, Williams, Çiğdem H., Venkitaraman, Ashok R.

“…The controlled release of RNA polymerase II (RNAPII) from promoter-proximal pausing (PPP) sites is critical for transcription elongation in metazoans. We show…”
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High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy by Short, Judith M, Liu, Yang, Chen, Shaoxia, Soni, Neelesh, Madhusudhan, Mallur S, Shivji, Mahmud K K, Venkitaraman, Ashok R

“…Homologous DNA recombination (HR) by the RAD51 recombinase enables error-free DNA break repair. To execute HR, RAD51 first forms a presynaptic filament on…”
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Definition of a Short Region of XPG Necessary for TFIIH Interaction and Stable Recruitment to Sites of UV Damage by Thorel, Fabrizio, Constantinou, Angelos, Dunand-Sauthier, Isabelle, Nouspikel, Thierry, Lalle, Philippe, Raams, Anja, Jaspers, Nicolaas G. J., Vermeulen, Wim, Shivji, Mahmud K. K., Wood, Richard D., Clarkson, Stuart G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The BRC Repeats of BRCA2 Modulate the DNA-Binding Selectivity of RAD51 by Carreira, Aura, Hilario, Jovencio, Amitani, Ichiro, Baskin, Ronald J., Shivji, Mahmud K.K., Venkitaraman, Ashok R., Kowalczykowski, Stephen C.

“…The breast cancer susceptibility protein, BRCA2, is essential for recombinational DNA repair. BRCA2 delivers RAD51 to double-stranded DNA (dsDNA) breaks…”
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Nucleotide Excision Repair DNA Synthesis by DNA Polymerase .epsilon. in the Presence of PCNA, RFC, and RPA by Shivji, Mahmud K. K, Podust, Vladimir N, Huebscher, Ulrich, Wood, Richard D

“…In eukaryotes, nucleotide excision repair of DNA is a complex process that requires many polypeptides to perform dual incision and remove a segment of about 30…”
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Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2 by Tainer, John A, Shin, David S, Pellegrini, Luca, Daniels, Douglas S, Yelent, Biana, Craig, Lisa, Bates, Debbie, Yu, David S, Shivji, Mahmud K, Hitomi, Chiharu, Arvai, Andrew S, Volkmann, Niels, Tsuruta, Hiro, Blundell, Tom L, Venkitaraman, Ashok R

“…To clarify RAD51 interactions controlling homologous recombination, we report here the crystal structure of the full‐length RAD51 homolog from Pyrococcus…”
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Assaying for the dual incisions of nucleotide excision repair using DNA with a lesion at a specific site by Shivji, Mahmud K K, Moggs, Jonathan G, Kuraoka, Isao, Wood, Richard D

“…Analysis of the mechanism of nucleotide excision repair (NER) using cell-free extract systems and purified proteins requires DNA substrates containing…”
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A thermostable endonuclease III homolog from the archaeon Pyrobaculum aerophilum by Yang, H, Phan, I T, Fitz-Gibbon, S, Shivji, M K, Wood, R D, Clendenin, W M, Hyman, E C, Miller, J H

“…Pyrimidine adducts in cellular DNA arise from modification of the pyrimidine 5,6-double bond by oxidation, reduction or hydration. The biological outcome…”
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Does the p53 Up-Regulated Gadd45 Protein Have a Role in Excision Repair? by Kazantsev, Aleksey, Sancar, Aziz, Kearsey, Jonathan M., Mahmud K. K. Shivji, Hall, Peter A., Wood, Richard D., Smith, Martin L., I-T Chen, Fornace, Albert J.

“…Excision repair in DNA could not be stimulated by Gadd45 protein. This result indicates that Gadd45 does not have any effect on the activity of human excision…”
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DNA recombination, chromosomal stability and carcinogenesis: insights into the role of BRCA2 by Shivji, Mahmud K.K., Venkitaraman, Ashok R.

“…Germline mutations affecting a single allele of BRCA2 increase susceptibility to breast and ovarian cancer, whilst germline inheritance of certain bi-allelic…”
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Resistance of human nucleotide excision repair synthesis in vitro to p21Cdn1 by SHIVJI, M. K, FERRARI, E, BALL, K, HÜBSCHER, U, WOOD, R. D

“…The p21Cdn1 protein (cip1/waf1/sdi1) plays an important role as an inhibitor of mammalian cell proliferation in response to DNA damage. By interacting with and…”
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DNA recombination, chromosomal stability and carcinogenesis: insights into the role of BRCA2: Bridge over broken ends: The cellular response to DNA breaks in health and disease by SHIVJI, Mahmud K. K, VENKITARAMAN, Ashok R

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The Evolutionarily Conserved Zinc Finger Motif in the Largest Subunit of Human Replication Protein A Is Required for DNA Replication and Mismatch Repair but Not for Nucleotide Excision Repair by Lin, Yi-Ling, Shivji, Mahmud K.K., Chen, Clark, Kolodner, Richard, Wood, Richard D., Dutta, Anindya

“…The largest subunit of the replication protein A (RPA) contains an evolutionarily conserved zinc finger motif that lies outside of the domains required for…”
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Does the p53 up-regulated Gadd45 protein have a role in excision repair? by Kearsey, J M, Shivji, M K, Hall, P A, Wood, R D

“…Fornace and colleagues identified GADD45 as an mRNA species with elevated expression in cells that have undergone growth arrest or DNA damage. The mRNA is…”
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