Search Results - "Shivarathri, Raju"

The Fungal Histone Acetyl Transferase Gcn5 Controls Virulence of the Human Pathogen Candida albicans through Multiple Pathways by Shivarathri, Raju, Tscherner, Michael, Zwolanek, Florian, Singh, Nitesh Kumar, Chauhan, Neeraj, Kuchler, Karl

“…Fungal virulence is regulated by a tight interplay of transcriptional control and chromatin remodelling. Despite compelling evidence that lysine acetylation…”
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Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs? by Kuchler, Karl, Jenull, Sabrina, Shivarathri, Raju, Chauhan, Neeraj

“…[...]there is increasing and compelling evidence that modulating the amplitude and magnitude of the host inflammatory immune response can be beneficial for the…”
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Fluconazole‐induced actin cytoskeleton remodeling requires phosphatidylinositol 3‐phosphate 5‐kinase in the pathogenic yeast Candida glabrata by Bhakt, Priyanka, Shivarathri, Raju, Choudhary, Deepak Kumar, Borah, Sapan, Kaur, Rupinder

“…Summary Known azole antifungal resistance mechanisms include mitochondrial dysfunction and overexpression of the sterol biosynthetic target enzyme and…”
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The Candida auris Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence by Shivarathri, Raju, Chauhan, Manju, Datta, Abhishek, Das, Diprasom, Karuli, Adela, Aptekmann, Ariel, Jenull, Sabrina, Kuchler, Karl, Thangamani, Shankar, Chowdhary, Anuradha, Desai, Jigar V, Chauhan, Neeraj

“…, a multidrug-resistant human fungal pathogen, was first identified in 2009 in Japan. Since then, systemic infections have now been reported in more than 50…”
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The Rho1 GTPase-activating Protein CgBem2 Is Required for Survival of Azole Stress in Candida glabrata by Borah, Sapan, Shivarathri, Raju, Kaur, Rupinder

“…Invasive fungal infections are common clinical complications of neonates, critically ill, and immunocompromised patients worldwide. Candida species are the…”
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The Two-Component Response Regulator Ssk1 and the Mitogen-Activated Protein Kinase Hog1 Control Antifungal Drug Resistance and Cell Wall Architecture of Candida auris by Shivarathri, Raju, Jenull, Sabrina, Stoiber, Anton, Chauhan, Manju, Mazumdar, Rounik, Singh, Ashutosh, Nogueira, Filomena, Kuchler, Karl, Chowdhary, Anuradha, Chauhan, Neeraj

“…Candida auris is an emerging multidrug-resistant (MDR) fungal pathogen that presents a serious global threat to human health. The Centers for Disease Control…”
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Transcriptomics and Phenotyping Define Genetic Signatures Associated with Echinocandin Resistance in Candida auris by Jenull, Sabrina, Shivarathri, Raju, Tsymala, Irina, Penninger, Philipp, Trinh, Phan-Canh, Nogueira, Filomena, Chauhan, Manju, Singh, Ashutosh, Petryshyn, Andriy, Stoiber, Anton, Chowdhary, Anuradha, Chauhan, Neeraj, Kuchler, Karl

“…Candida auris emerged as a human fungal pathogen only during the past decade. Remarkably, C. auris displays high degrees of genomic diversity and phenotypic…”
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Transcriptome Signatures Predict Phenotypic Variations of Candida auris by Jenull, Sabrina, Tscherner, Michael, Kashko, Nataliya, Shivarathri, Raju, Stoiber, Anton, Chauhan, Manju, Petryshyn, Andriy, Chauhan, Neeraj, Kuchler, Karl

“…Health care facilities are facing serious threats by the recently emerging human fungal pathogen owing to its pronounced antifungal multidrug resistance and…”
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Comparative Transcriptomics Reveal Possible Mechanisms of Amphotericin B Resistance in Candida auris by Shivarathri, Raju, Jenull, Sabrina, Chauhan, Manju, Singh, Ashutosh, Mazumdar, Rounik, Chowdhary, Anuradha, Kuchler, Karl, Chauhan, Neeraj

“…Candida auris is an emerging multidrug-resistant human fungal pathogen often refractory to treatment by all classes of antifungal drugs. Amphotericin B (AmB)…”
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P008 Molecular mechanisms associated with fluconazole resistance and genetic diversity in clinical Candida krusei isolates from North India by Jain, Kusum, Shivarathri, Raju, Bashir, Gulnaz, Chauhan, Neeraj, Chowdhary, Anuradha

“…Abstract Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM   Objectives Candida krusei accounts for 2.8% of invasive candidiasis worldwide. Fluconazole…”
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P021 Comparative transcriptomic analysis of environmental Candida auris showing variable azole susceptibility by Jain, Kusum, Shivarathri, Raju, Singh, Ashutosh, Chauhan, Neeraj, Chowdhary, Anuradha

“…Abstract Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM   Objective Candida auris is a multidrug-resistant pathogen that presents a serious global…”
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A Proteomic Approach for the Quantification of Posttranslational Protein Lysine Acetylation in Candida albicans by Shivarathri, Raju, Chauhan, Manju, Mazumdar, Rounik, Trinh, Phan Canh, Reiter, Wolfgang, Hartl, Markus, Kuchler, Karl, Chauhan, Neeraj

“…Candida albicans is a normal component of the human microflora that colonizes mucosal/epithelial surfaces and the gastrointestinal tract as a commensal…”
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C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection by Desai, Jigar V., Kumar, Dhaneshwar, Freiwald, Tilo, Chauss, Daniel, Johnson, Melissa D., Abers, Michael S., Steinbrink, Julie M., Perfect, John R., Alexander, Barbara, Matzaraki, Vasiliki, Snarr, Brendan D., Zarakas, Marissa A., Oikonomou, Vasileios, Silva, Lakmali M., Shivarathri, Raju, Beltran, Emily, Demontel, Luciana Negro, Wang, Luopin, Lim, Jean K., Launder, Dylan, Conti, Heather R., Swamydas, Muthulekha, McClain, Micah T., Moutsopoulos, Niki M., Kazemian, Majid, Netea, Mihai G., Kumar, Vinod, Köhl, Jörg, Kemper, Claudia, Afzali, Behdad, Lionakis, Michail S.

“…Systemic candidiasis is a common, high-mortality, nosocomial fungal infection. Unexpectedly, it has emerged as a complication of anti-complement C5-targeted…”
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Pivotal role for a tail subunit of the RNA polymerase II mediator complex CgMed2 in azole tolerance and adherence in Candida glabrata by Borah, Sapan, Shivarathri, Raju, Srivastava, Vivek Kumar, Ferrari, Sélène, Sanglard, Dominique, Kaur, Rupinder

“…Antifungal therapy failure can be associated with increased resistance to the employed antifungal agents. Candida glabrata, the second most common cause of…”
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The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence by Jenull, Sabrina, Mair, Theresia, Tscherner, Michael, Penninger, Philipp, Zwolanek, Florian, Silao, Fitz-Gerald S., de San Vicente, Kontxi Martinez, Riedelberger, Michael, Bandari, Naga C., Shivarathri, Raju, Petryshyn, Andriy, Chauhan, Neeraj, Zacchi, Lucia F., -Landmann, Salomé LeibundGut, Ljungdahl, Per O., Kuchler, Karl

“…Adaptation to changing environments and immune evasion is pivotal for fitness of pathogens. Yet, the underlying mechanisms remain largely unknown. Adaptation…”
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