Chromosomal aberrations in myelodysplastic syndrome

To analyse incidence rate of chromosomal aberrations in myelodysplastic syndromes (MDS), specification of clinicomorphological features of some cytogenetic variants. Chromosomal analysis by the method of G-differential staining of chromosomes was made in 209 patients with different variants of MDS....

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Bibliographic Details
Published in:	Terapevtic̆eskii arhiv Vol. 77; no. 7; p. 27
Main Authors:	Ol'shanskaia, Iu V, Domracheva, E V, Udovichenko, A I, Vodinskaia, L A, Zakharova, A V, Parovichnikova, E N, Tsvetaeva, N V, Mikhaĭlova, E A, Glasko, E N, Kolosova, L Iu, Kokhno, A N, Tikhonova, L Iu, Shitareva, T V, Smirnova, E A, Alimova, G A, Shirin, A D, Vinogradova, O Iu, Khoroshko, N D, Savchenko, V G
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2005
Subjects:	Adolescent Adult Aged Aged, 80 and over Chromosome Aberrations - statistics & numerical data Chromosomes, Human, Pair 5 - genetics Chromosomes, Human, Pair 7 - genetics Chromosomes, Human, Pair 8 - genetics Chromosomes, Human, X - genetics Chromosomes, Human, Y - genetics Cytogenetic Analysis Female Humans Karyotyping Male Middle Aged Monosomy - genetics Monosomy - pathology Myelodysplastic Syndromes - classification Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - genetics Prognosis Retrospective Studies Trisomy - genetics Trisomy - pathology
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Summary:	To analyse incidence rate of chromosomal aberrations in myelodysplastic syndromes (MDS), specification of clinicomorphological features of some cytogenetic variants. Chromosomal analysis by the method of G-differential staining of chromosomes was made in 209 patients with different variants of MDS. RESULTS; Clonal chromosomal aberrations occured in 60.8%. The following aberrations were found most frequently: deletion of the long arm of the chromosome 5 (del(5q)) - 34.6%, trisomy of chromosome 8 (14.1%), monosomy of chromosome 7 (13.4%), aberrations 3q21q26 (12.6%), aberrations of a long arm of X-chromosome (4.7%), the absence of Y-chromosome (3.1%). Complex aberrations of karyotype were found in 13.5% cases. Chromosomal aberrations determined not only clinical and morphological features but also the prognosis of the disease. Cytogenetic examination is an essential component of MDS patients examination. It allows more precise classification of MDS variant and prognostification of the disease course.
ISSN:	0040-3660