Search Results - "Shitaka, Yoshitsugu"

Repetitive Closed-Skull Traumatic Brain Injury in Mice Causes Persistent Multifocal Axonal Injury and Microglial Reactivity by Shitaka, Yoshitsugu, Tran, Hien T, Bennett, Rachel E, Sanchez, Laura, Levy, Marilyn A, Dikranian, Krikor, Brody, David L

“…Repetitive mild or "concussive" traumatic brain injury (TBI) can cause substantial neurologic impairment, but the pathological features of this type of injury…”
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Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine by Nagakura, Akira, Shitaka, Yoshitsugu, Yarimizu, Junko, Matsuoka, Nobuya

“…Alzheimer's disease is characterized by a progressive decline in cognitive function and involves β-amyloid (Aβ) in its pathogenesis. To characterize cognitive…”
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Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer's disease by Kanamaru, Takuya, Kamimura, Naomi, Yokota, Takashi, Iuchi, Katsuya, Nishimaki, Kiyomi, Takami, Shinya, Akashiba, Hiroki, Shitaka, Yoshitsugu, Katsura, Ken-ichiro, Kimura, Kazumi, Ohta, Shigeo

“…•We have established a novel mouse model of Alzheimer’s disease (the APP/DAL mouse).•Pathological changes and memory impairment are accelerated in the APP/DAL…”
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Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer’s disease by Kanamaru, Takuya, Kamimura, Naomi, Yokota, Takashi, Nishimaki, Kiyomi, Iuchi, Katsuya, Lee, Hyunjin, Takami, Shinya, Akashiba, Hiroki, Shitaka, Yoshitsugu, Ueda, Masayuki, Katsura, Ken-ichiro, Kimura, Kazumi, Ohta, Shigeo

“…Abstract Stem cell transplantation therapy is currently in clinical trials for the treatment of ischemic stroke, and several beneficial aspects have been…”
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Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models by Kohara, Atsuyuki, Takahashi, Masayasu, Yatsugi, Shin-ichi, Tamura, Seiji, Shitaka, Yoshitsugu, Hayashibe, Satoshi, Kawabata, Shigeki, Okada, Masamichi

“…Abstract We describe in vitro properties and in vivo neuroprotective effects of a newly synthesized, high-affinity, selective allosteric metabotropic glutamate…”
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Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1 by Kohara, Atsuyuki, Toya, Takashi, Tamura, Seiji, Watabiki, Tomonari, Nagakura, Yukinori, Shitaka, Yoshitsugu, Hayashibe, Satoshi, Kawabata, Shigeki, Okada, Masamichi

“…Metabotropic glutamate receptor type 1 (mGluR1) is thought to play important roles in the neurotransmission and pathogenesis of several neurological disorders…”
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Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models by Kohara, Atsuyuki, Nagakura, Yukinori, Kiso, Tetsuo, Toya, Takashi, Watabiki, Tomonari, Tamura, Seiji, Shitaka, Yoshitsugu, Itahana, Hirotsune, Okada, Masamichi

“…Metabotropic glutamate receptor 1 (mGlu 1 receptor) has been suggested to play an important role in pain transmission. In this study, the effects of a…”
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Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice by Mitani, Yasuyuki, Yarimizu, Junko, Saita, Kyoko, Uchino, Hiroshi, Akashiba, Hiroki, Shitaka, Yoshitsugu, Ni, Keni, Matsuoka, Nobuya

“…γ-Secretase inhibitors (GSIs) reduce amyloid-β (Aβ) peptides but inevitably increase the β-C-terminal fragment (β-CTF) of amyloid precursor protein (APP),…”
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Amelioration of cognitive deficits in plaque-bearing Alzheimer's disease model mice through selective reduction of nascent soluble A beta 42 without affecting other A beta pools by Mitani, Yasuyuki, Yarimizu, Junko, Akashiba, Hiroki, Shitaka, Yoshitsugu, Ni, Keni, Matsuoka, Nobuya

“…Given that amyloid- beta 42 (A beta 42) is believed to be a culprit in Alzheimer's disease (AD), reducing A beta 42 production should be a potential…”
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Pharmacological characterization of the novel γ-secretase modulator AS2715348, a potential therapy for Alzheimer's disease, in rodents and nonhuman primates by Mitani, Yasuyuki, Akashiba, Hiroki, Saita, Kyoko, Yarimizu, Junko, Uchino, Hiroshi, Okabe, Mayuko, Asai, Makoto, Yamasaki, Shingo, Nozawa, Takashi, Ishikawa, Noritoshi, Shitaka, Yoshitsugu, Ni, Keni, Matsuoka, Nobuya

“…γ-Secretase is the enzyme responsible for the intramembranous proteolysis of various substrates, such as amyloid precursor protein (APP) and Notch. Amyloid-β…”
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Amelioration of cognitive deficits in plaque‐bearing Alzheimer's disease model mice through selective reduction of nascent soluble Aβ42 without affecting other Aβ pools by Mitani, Yasuyuki, Yarimizu, Junko, Akashiba, Hiroki, Shitaka, Yoshitsugu, Ni, Keni, Matsuoka, Nobuya

“…Given that amyloid‐β 42 (Aβ42) is believed to be a culprit in Alzheimer's disease (AD), reducing Aβ42 production should be a potential therapeutic approach…”
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Amelioration of cognitive deficits in plaque-bearing Alzheimer's disease model mice through selective reduction of nascent soluble A[beta]42 without affecting other A[beta] pools by Mitani, Yasuyuki, Yarimizu, Junko, Akashiba, Hiroki, Shitaka, Yoshitsugu, Ni, Keni, Matsuoka, Nobuya

“…Given that amyloid-[beta] 42 (A[beta]42) is believed to be a culprit in Alzheimer's disease (AD), reducing A[beta]42 production should be a potential…”
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Amelioration of cognitive deficits in plaque‐bearing A lzheimer's disease model mice through selective reduction of nascent soluble A42 without affecting other A pools by Mitani, Yasuyuki, Yarimizu, Junko, Akashiba, Hiroki, Shitaka, Yoshitsugu, Ni, Keni, Matsuoka, Nobuya

“…Abstract Given that amyloid‐β 42 (Aβ42) is believed to be a culprit in Alzheimer's disease ( AD ), reducing Aβ42 production should be a potential therapeutic…”
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Characterization of cognitive functions of Tg2576 mouse model for Alzheimer's disease with multiple cognitive tasks by Nagakura, Akira, Yarimizu, Junko, Takahashi, Masayasu, Shitaka, Yoshitsugu, Miyake, Akira, Matsuoka, Nobuya

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P1‐143: Characterization of cognitive functions of Tg2576 mouse model for Alzheimer's disease with multiple cognitive tasks by Nagakura, Akira, Yarimizu, Junko, Takahashi, Masayasu, Shitaka, Yoshitsugu, Miyake, Akira, Matsuoka, Nobuya

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Progress in the development of anti-amyloid drugs for treatment of Alzheimer's disease. by Shitaka, Yoshitsugu, Mitani, Yasuyuki, Nagakura, Akira, Miyake, Akira, Matsuoka, Nobuya

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Exclusive association and simultaneous appearance of congophilic plaques and AT8-positive dystrophic neurites in Tg2576 mice suggest a mechanism of senile plaque formation and progression of neuritic dystrophy in Alzheimer's disease by Noda-Saita, Kyoko, Terai, Kazuhiro, Iwai, Akihiko, Tsukamoto, Mina, Shitaka, Yoshitsugu, Kawabata, Shigeki, Okada, Masamichi, Yamaguchi, Tokio

“…Progression of neuritic dystrophy is a histological hallmark of Alzheimer's disease (AD) in addition to amyloid deposition and neurofibrillary tangle…”
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P3‐298: In vivo efficacy of BACE‐1 inhibitor CTS21166 (ASP1702) in rat CNS compartments by Yu, Jeremy, Koelsch, Gerald, Li, Aiqun, Turner, Robert T., Bilcer, Geoffrey M., Grove, Carl, Hsu, Henry H., Shitaka, Yoshitsugu, Hamakawa, Nozomu, Terashita, Shigeyuki, Matsuoka, Nobuya, Tang, Jordan, Ghosh, Arun K., Hey, John A.

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Basic Fibroblast Growth Factor Increases Functional L-Type Ca2+ Channels in Fetal Rat Hippocampal Neurons: Implications for Neurite Morphogenesis In Vitro by Shitaka, Yoshitsugu, Matsuki, Norio, Saito, Hiroshi, Katsuki, Hiroshi

“…Basic fibroblast growth factor (bFGF) is a potent neurotrophic factor that regulates cell proliferation and differentiation during neuronal development. Here…”
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IC-P-049: A novel quantitative analysis method of β-amyloid plaques in model mice of Alzheimer’s disease using a phase-contrast X-ray imaging technique by Yoneyama, Akio, Noda-Saita, Kyoko, Shitaka, Yoshitsugu, Takeda, Tohoru, Hyodo, Kazuyuki, Hirai, Yasuharu

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