Demonstration of aqueous streaming through a laser iridotomy window against the corneal endothelium

To determine the pathogenesis of the bullous keratopathy that is frequently observed in patients after argon laser iridotomy (ALI) by comparing the changes in aqueous flow after ALI with those that follow peripheral iridectomy in rabbit eyes. Silicone particles were injected into the anterior chambe...

Full description

Saved in:

Bibliographic Details
Published in:	Archives of ophthalmology (1960) Vol. 124; no. 3; p. 387
Main Authors:	Yamamoto, Yasuaki, Uno, Toshihiko, Shisida, Katsumi, Xue, Longquan, Shiraishi, Atsushi, Zheng, Xiaodong, Ohashi, Yuichi
Format:	Journal Article
Language:	English
Published:	United States 01-03-2006
Subjects:	Animals Anterior Chamber - metabolism Aqueous Humor - secretion Endothelium, Corneal - metabolism Iridectomy Iris - metabolism Iris - surgery Laser Therapy Microspheres Ostomy Pupil - physiology Pupil - radiation effects Rabbits Rheology Silicone Elastomers
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	To determine the pathogenesis of the bullous keratopathy that is frequently observed in patients after argon laser iridotomy (ALI) by comparing the changes in aqueous flow after ALI with those that follow peripheral iridectomy in rabbit eyes. Silicone particles were injected into the anterior chamber of rabbit eyes as tracers to monitor aqueous flow. Particle tracking velocimetry with image analysis was used to determine the direction and speed of aqueous flow in 5 pigmented rabbits that underwent ALI and 5 that underwent peripheral iridectomy. In the ALI group, silicone particles were found to stream through the iridotomy window against the corneal endothelium immediately after the pupil was constricted by a light stimulus. The mean +/- SD speed of the particles was 2.97 +/- 1.51 mm/s. In contrast, the mean +/- SD flow rate through the iridectomy window in the peripheral iridectomy group was significantly slower at 0.36 +/- 0.30 mm/s (P = .01). Constriction of the pupil elicited marked aqueous streaming through the ALI window against the corneal endothelium. Clinical Relevance The mechanical stress to the corneal endothelium by the abnormal aqueous stream may be partially responsible for the corneal decompensation that follows ALI.
ISSN:	0003-9950
DOI:	10.1001/archopht.124.3.387