Synthesis of 3,5-Di-tert-butyl-1,2-dihydroxybenzene Derivatives and Their Effect on Free-Radical Oxidation of Hexane and Oxygen Activation Ability of Neutrophils

C 6 -Substituted derivatives of 3,5-di- tert -butyl-1,2-dihydroxybenzene have been synthesized, and their effect on radiation-induced free-radical oxidation of n -hexane and production of reactive oxygen and chlorine forms in neutrophils have been studied. It has been shown the introduction of the p...

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Bibliographic Details
Published in:	Russian journal of general chemistry Vol. 89; no. 3; pp. 391 - 398
Main Authors:	Ksendzova, G. A., Ostrovskaya, N. I., Semenkova, G. N., Sorokin, V. L., Shishkanova, P. A., Shadyro, O. I.
Format:	Journal Article
Language:	English
Published:	Moscow Pleiades Publishing 01-03-2019 Springer Springer Nature B.V
Subjects:	Active oxygen Antioxidants Chemistry Chemistry and Materials Science Chemistry/Food Science Chlorine Derivatives Free radicals Medical research Medicine, Experimental Neutrophils Oxidation Oxidation-reduction reaction Oxygen Radiation effects Virus diseases reactive oxygen and chlorine forms myeloperoxidase sterically hindered pyrocatechol antioxidant activity neutrophils chemiluminescence
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Summary:	C 6 -Substituted derivatives of 3,5-di- tert -butyl-1,2-dihydroxybenzene have been synthesized, and their effect on radiation-induced free-radical oxidation of n -hexane and production of reactive oxygen and chlorine forms in neutrophils have been studied. It has been shown the introduction of the phenylhydrazone and phenylazomethine groups significantly increases the antioxidant activity of pyrocatechol derivatives. For six compounds, the ability to prevent the development of oxidative stress due to hyperproduction of active oxygen intermediates and HOCl/OCl − in neutrophils has been revealed.
ISSN:	1070-3632 1608-3350
DOI:	10.1134/S1070363219030046