Search Results - "Shishido, Yuko"
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Chemoselective and Direct Functionalization of Methyl Benzyl Ethers and Unsymmetrical Dibenzyl Ethers by Using Iron Trichloride
Published in Chemistry : a European journal (24-02-2014)“…Methyl and benzyl ethers are widely utilized as protected alcohols due to their chemical stability, such as the low reactivity of the methoxy and benzyloxy…”
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Biarylmethane and Fused Heterocyclic Arene Synthesis via in Situ Generated o- and/or p‑Naphthoquinone Methides
Published in Journal of organic chemistry (05-06-2015)“…o- and/or p-naphthoquinone methides (NQMs) can be selectively prepared by the ring opening of 1-(siloxymethyl)-1,4-epoxy-1,4-dihydronaphthalene derivatives…”
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3
Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells
Published in Molecular pharmaceutics (06-06-2016)“…Glutathione transferases (GSTs) are often overexpressed in tumors and frequently correlated to bad prognosis and resistance against a number of different…”
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A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP 1-1 )
Published in Chemical communications (Cambridge, England) (10-10-2017)“…We herein report the first covalent G-site-binding inhibitor for GST, GS-ESF (1), which irreversibly inhibited the GSTP function. LC-MS/MS and X-ray structure…”
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Iron-Catalyzed Friedel-Crafts Benzylation with Benzyl TMS Ethers at Room Temperature
Published in Chemistry : a European journal (07-01-2014)“…Friedel–Crafts benzylations between unactivated arenes and benzyl alcohol derivatives are clean and straightforward processes to construct biologically useful…”
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A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells
Published in Chembiochem : a European journal of chemical biology (01-04-2019)“…Glutathione S‐transferase π (GSTP1‐1) is overexpressed in many types of cancer and is involved in drug resistance. Therefore, GSTP1‐1 is an important target in…”
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Efficient Generation of ortho-Naphthoquinone Methides from 1,4-Epoxy-1,4-dihydronaphthalenes and Their Annulation with Allyl Silanes
Published in Angewandte Chemie International Edition (28-01-2013)“…Pharmaceutically useful dihydronaphthopyran derivatives were obtained in good yield by the regio‐ and stereoselective annulation of ortho‐naphthoquinone…”
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Palladium-Catalyzed C–H Monoalkoxylation of α,β-Unsaturated Carbonyl Compounds
Published in ACS catalysis (03-06-2016)“…An efficient method for the direct introduction of alkoxy groups into the β-position of alkene moieties of various α,β-unsaturated carbonyl compounds through…”
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Acetal Elimination Reaction Accompanied with Regioselective Ring Opening of 1,4-Bisacetal-1,4-epoxy-1,4-dihydronaphthalenes
Published in Heterocycles (2019)Get full text
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Efficient Generation of ortho-Naphthoquinone Methides from 1,4-Epoxy-1,4-dihydronaphthalenes and Their Annulation with Allyl Silanes
Published in Angewandte Chemie (28-01-2013)“…Pharmazeutisch nützliche Dihydronaphthopyrane wurden in guter Ausbeute durch die regio‐ und stereoselektive Anellierung von ortho‐Naphthochinonmethiden mit…”
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Invasive group B streptococcal infection in a patient with post splenectomy for hypersplenism secondary to liver cirrhosis and portal hypertension
Published in World journal of emergency medicine (2016)“…BACKGROUND:Splenectomy in patients with liver cirrhosis(LC)is expected to become more common owing to its efficacy on portal hemodynamics.In this report we…”
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