Search Results - "Shirwan, Haval"

Current challenges for cancer vaccine adjuvant development by Bowen, William S, Svrivastava, Abhishek K, Batra, Lalit, Barsoumian, Hampartsoum, Shirwan, Haval

“…Although much progress has been made in the last decade(s) toward development of effective cancer vaccines, there are still important obstacles to therapeutic…”
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Establishment of Translational Luciferase-Based Cancer Models to Evaluate Antitumoral Therapies by Ramos-Gonzalez, Martin R, Sirpu Natesh, Nagabhishek, Rachagani, Satyanarayana, Amos-Landgraf, James, Shirwan, Haval, Yolcu, Esma S, Gomez-Gutierrez, Jorge G

“…Luciferase (luc) bioluminescence (BL) is the most used light-emitting protein that has been engineered to be expressed in multiple cancer cell lines, allowing…”
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4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4+CD25+FoxP3+ T Regulatory Cell Suppression by Barsoumian, Hampartsoum B, Yolcu, Esma S, Shirwan, Haval

“…Costimulation with the recombinant SA-4-1BBL agonist of 4-1BB receptor on conventional CD4+ T cells (Tconvs) overcomes the suppression mediated by naturally…”
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SA-4-1BBL and monophosphoryl lipid A constitute an efficacious combination adjuvant for cancer vaccines by Srivastava, Abhishek K, Dinc, Gunes, Sharma, Rajesh K, Yolcu, Esma S, Zhao, Hong, Shirwan, Haval

“…Vaccines based on tumor-associated antigens (TAA) have limited therapeutic efficacy due to their weak immunogenic nature and the various immune evasion…”
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A modified surgical procedure using minimally invasive ileocolic vein perfusion in a mouse intrahepatic islet transplant model by Zhang, Lei, Turan, Ali, Shirwan, Haval, Yolcu, Esma S.

“…Murine intrahepatic islet transplantation is a clinically relevant but technically challenging surgical procedure because of frequent lethal postoperative…”
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Protocol for transplanting pancreatic islets into the parametrial fat pad of female mice by Tedla, Mebrahtu G., Wright, Nathaniel, Yolcu, Esma S., Wang, Yadong, Shirwan, Haval

“…Although the male epididymal fat pad is an effective site for islet transplantation, females lack this tissue. Here, we present a protocol to assess the…”
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CD4+ T cells play a critical role in the generation of primary and memory antitumor immune responses elicited by SA-4-1BBL and TAA-based vaccines in mouse tumor models by Sharma, Rajesh K, Yolcu, Esma S, Srivastava, Abhishek K, Shirwan, Haval

“…The role of CD4(+) T cells in the generation of therapeutic primary and memory immune responses in cancer diverse immunotherapy settings remains ambiguous. We…”
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Oncolytic Adenovirus Armed with a Novel Agonist of the CD137 Immune Checkpoint Stimulator Suppresses Tumor Growth by Ramos-Gonzalez, Martin R, Tarique, Mohammad, Batra, Lalit, Arguc, Feyza, Garza-Morales, Rodolfo, Shirwan, Haval, Yolcu, Esma S, Gomez-Gutierrez, Jorge G

“…Natural 4-1BBL (CD137L) is a cell membrane-bound protein critical to the expansion, effector function, and survival of CD8 T cells. We reported the generation…”
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Local immunomodulation Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance by Headen, Devon M, Woodward, Kyle B, Coronel, María M, Shrestha, Pradeep, Weaver, Jessica D, Zhao, Hong, Tan, Min, Hunckler, Michael D, Bowen, William S, Johnson, Christopher T, Shea, Lonnie, Yolcu, Esma S, García, Andrés J, Shirwan, Haval

“…Islet transplantation is a promising therapy for type 1 diabetes. However, chronic immunosuppression to control rejection of allogeneic islets induces…”
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Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumors by Sharma, Rajesh K, Elpek, Kutlu G, Yolcu, Esma S, Schabowsky, Rich-Henry, Zhao, Hong, Bandura-Morgan, Laura, Shirwan, Haval

“…Vaccines represent an attractive treatment modality for the management of cancer primarily because of their specificity and generation of immunologic memory…”
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Killer Treg cells ameliorate inflammatory insulitis in non-obese diabetic mice through local and systemic immunomodulation by Kaminitz, Ayelet, Yolcu, Esma S, Mizrahi, Keren, Shirwan, Haval, Askenasy, Nadir

“…Treg cells endowed with enhanced killing activity through decoration with Fas-ligand (FasL) protein (killer Treg) have been effective in delay of hyperglycemia…”
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SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ by Madireddi, Shravan, Schabowsky, Rich-Henry, Srivastava, Abhishek K, Sharma, Rajesh K, Yolcu, Esma S, Shirwan, Haval

“…Tumors convert conventional CD4(+) T cells into induced CD4(+)CD25(+)FoxP3(+) T regulatory (iTreg) cells that serve as an effective means of immune evasion…”
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Induction of tolerance using Fas ligand: a double-edged immunomodulator by Askenasy, Nadir, Yolcu, Esma S., Yaniv, Isaac, Shirwan, Haval

“…Apoptosis mediated by Fas ligand (FasL) interaction with Fas receptor plays a pivotal regulatory role in immune homeostasis, immune privilege, and…”
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Prime-boost vaccination with SA-4-1BBL costimulatory molecule and survivin eradicates lung carcinoma in CD8+ T and NK cell dependent manner by Srivastava, Abhishek K, Sharma, Rajesh K, Yolcu, Esma S, Ulker, Vahap, MacLeod, Kathryn, Dinc, Gunes, Shirwan, Haval

“…Subunit vaccines containing universal tumor associated antigens (TAAs) present an attractive treatment modality for cancer primarily due to their safety and…”
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4-1BB Ligand as an Effective Multifunctional Immunomodulator and Antigen Delivery Vehicle for the Development of Therapeutic Cancer Vaccines by SHARMA, Rajesh K, SCHABOWSKY, Rich-Henry, SHIRWAN, Haval, SRIVASTAVA, Abhishek K, ELPEK, Kutlu G, MADIREDD, Shravan, HONG ZHAO, ZHENPING ZHONG, MILLER, Robert W, MACLEOD, Kathryn J, YOLCU, Esma S

“…Therapeutic subunit vaccines based on tumor-associated antigens (TAA) represent an attractive approach for the treatment of cancer. However, poor…”
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Tumor Necrosis Factor Receptors Support Murine Hematopoietic Progenitor Function in the Early Stages of Engraftment by Pearl‐Yafe, Michal, Mizrahi, Keren, Stein, Jerry, Yolcu, Esma S., Kaplan, Ofer, Shirwan, Haval, Yaniv, Isaac, Askenasy, Nadir

“…Tumor necrosis factor (TNF) family receptors/ligands are important participants in hematopoietic homeostasis, in particular as essential negative expansion…”
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Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting by Miller, Mark Steven, Allen, Peter J, Brown, Powel H, Chan, Andrew T, Clapper, Margie L, Dashwood, Roderick H, Demehri, Shadmehr, Disis, Mary L, DuBois, Raymond N, Glynn, Robert J, Kensler, Thomas W, Khan, Seema A, Johnson, Bryon D, Liby, Karen T, Lipkin, Steven M, Mallery, Susan R, Meuillet, Emmanuelle J, Roden, Richard B S, Schoen, Robert E, Sharp, Zelton D, Shirwan, Haval, Siegfried, Jill M, Rao, Chinthalapally V, You, Ming, Vilar, Eduardo, Szabo, Eva, Mohammed, Altaf

“…The Division of Cancer Prevention of the National Cancer Institute (NCI) and the Office of Disease Prevention of the National Institutes of Health co-sponsored…”
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Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice by Kaminitz, Ayelet, Yolcu, Esma S, Askenasy, Enosh M, Stein, Jerry, Yaniv, Isaac, Shirwan, Haval, Askenasy, Nadir

“…Disturbed peripheral negative regulation might contribute to evolution of autoimmune insulitis in type 1 diabetes. This study evaluates the sensitivity of…”
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226.8: Targeting apoptotic pathway to eliminate Teff cells as an effective approach to prevent acute GVHD in a humanized mouse model by Yolcu, Esma, Shrestha, Pradeep, Turan, Ali, Shirwan, Haval

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Prophylactic fenbendazole therapy does not affect the incidence and onset of type 1 diabetes in non-obese diabetic mice by Franke, Deanna D. H., Shirwan, Haval

“…Fenbendazole (FBZ) is a common, highly efficacious broad-spectrum anthelmintic drug used to treat and limit rodent pinworm infections. However, the effect of…”
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