Search Results - "Shiroguchi, Katsuyuki"

Integration of single-cell manipulation, whole transcriptome analysis, and image-based deep learning for studying “Singularity Biology” by Shiroguchi, Katsuyuki

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Genome‐wide study of mRNA degradation and transcript elongation in Escherichia coli by Chen, Huiyi, Shiroguchi, Katsuyuki, Ge, Hao, Xie, Xiaoliang Sunney

“…An essential part of gene expression is the coordination of RNA synthesis and degradation, which occurs in the same cellular compartment in bacteria. Here, we…”
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Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation by Miyamoto, Chizuko, Kojo, Satoshi, Yamashita, Motoi, Moro, Kazuyo, Lacaud, Georges, Shiroguchi, Katsuyuki, Taniuchi, Ichiro, Ebihara, Takashi

“…Group 2 innate lymphoid cells (ILC2s) have tissue-resident competence and contribute to the pathogenesis of allergic diseases. However, the mechanisms…”
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High-throughput identification and quantification of single bacterial cells in the microbiota by Jin, Jianshi, Yamamoto, Reiko, Takeuchi, Tadashi, Cui, Guangwei, Miyauchi, Eiji, Hojo, Nozomi, Ikuta, Koichi, Ohno, Hiroshi, Shiroguchi, Katsuyuki

“…The bacterial microbiota works as a community that consists of many individual organisms, i.e., cells. To fully understand the function of bacterial…”
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Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity by Kimura, Shunsuke, Nakamura, Yutaka, Kobayashi, Nobuhide, Shiroguchi, Katsuyuki, Kawakami, Eiryo, Mutoh, Mami, Takahashi-Iwanaga, Hiromi, Yamada, Takahiro, Hisamoto, Meri, Nakamura, Midori, Udagawa, Nobuyuki, Sato, Shintaro, Kaisho, Tsuneyasu, Iwanaga, Toshihiko, Hase, Koji

“…Microfold cells (M cells) are responsible for antigen uptake to initiate immune responses in the gut-associated lymphoid tissue (GALT). Receptor activator of…”
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Digital RNA sequencing minimizes sequence-dependent bias and amplification noise with optimized single-molecule barcodes by Shiroguchi, Katsuyuki, Jia, Tony Z, Sims, Peter A, Xie, X. Sunney

“…RNA sequencing (RNA-Seq) is a powerful tool for transcriptome profiling, but is hampered by sequence-dependent bias and inaccuracy at low copy numbers…”
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Identifying a Lung Stem Cell Subpopulation by Combining Single-Cell Morphometrics, Organoid Culture, and Transcriptomics by Fujimura, Takashi, Enomoto, Yasunori, Katsura, Hiroaki, Ogawa, Taisaku, Baba, Saori, Ogata, Akira, Yamaoka, Akira, Shiroguchi, Katsuyuki, Morimoto, Mitsuru

“…Abstract Single-cell RNA sequencing is a valuable tool for dissecting cellular heterogeneity in complex systems. However, it is still challenging to estimate…”
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Different cell imaging methods did not significantly improve immune cell image classification performance by Ogawa, Taisaku, Ochiai, Koji, Iwata, Tomoharu, Ikawa, Tomokatsu, Tsuzuki, Taku, Shiroguchi, Katsuyuki, Takahashi, Koichi

“…Developments in high-throughput microscopy have made it possible to collect huge amounts of cell image data that are difficult to analyse manually. Machine…”
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The efficacy and further functional advantages of random-base molecular barcodes for absolute and digital quantification of nucleic acid molecules by Ogawa, Taisaku, Kryukov, Kirill, Imanishi, Tadashi, Shiroguchi, Katsuyuki

“…Accurate quantification of biomolecules in system-wide measurements is in high demand, especially for systems with limited sample amounts such as single cells…”
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Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile by Nakai-Futatsugi, Yoko, Jin, Jianshi, Ogawa, Taisaku, Sakai, Noriko, Maeda, Akiko, Hironaka, Ken-Ichi, Fukuda, Masakazu, Danno, Hiroki, Tanaka, Yuji, Hori, Seiji, Shiroguchi, Katsuyuki, Takahashi, Masayo

“…Retinal pigment epithelium (RPE) cells show heterogeneous levels of pigmentation when cultured in vitro. To know whether their color in appearance is…”
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Nishida, Mikako, Yamashita, Nahoko, Ogawa, Taisaku, Koseki, Keita, Warabi, Eiji, Ohue, Tomoyuki, Komatsu, Masaaki, Matsushita, Hirokazu, Kakimi, Kazuhiro, Kawakami, Eiryo, Shiroguchi, Katsuyuki, Udono, Heiichiro

“…BackgroundMetformin (Met) is the first-line treatment for type 2 diabetes mellitus and plays an effective role in treating various diseases, such as…”
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BSJ 2019 “Single-cell PRESTO” session by Suzuki, Madoka, Shiroguchi, Katsuyuki

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Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors by Tenno, Mari, Kojo, Satoshi, Lawir, Divine-Fondzenyuy, Hess, Isabell, Shiroguchi, Katsuyuki, Ebihara, Takashi, Endo, Takaho A, Muroi, Sawako, Satoh, Rumi, Kawamoto, Hiroshi, Boehm, Thomas, Taniuchi, Ichiro

“…Multipotent hematopoietic progenitors must acquire thymus-homing capacity to initiate T lymphocyte development. Despite its importance, the transcriptional…”
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HaloTag-based conjugation of proteins to barcoding-oligonucleotides by Yazaki, Junshi, Kawashima, Yusuke, Ogawa, Taisaku, Kobayashi, Atsuo, Okoshi, Mayu, Watanabe, Takashi, Yoshida, Suguru, Kii, Isao, Egami, Shohei, Amagai, Masayuki, Hosoya, Takamitsu, Shiroguchi, Katsuyuki, Ohara, Osamu

“…Abstract Highly sensitive protein quantification enables the detection of a small number of protein molecules that serve as markers/triggers for various…”
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Author Correction: Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation by Miyamoto, Chizuko, Kojo, Satoshi, Yamashita, Motoi, Moro, Kazuyo, Lacaud, Georges, Shiroguchi, Katsuyuki, Taniuchi, Ichiro, Ebihara, Takashi

“…The original version of this Article contained an error in the author affiliations. Affiliation 5 incorrectly read ‘Laboratory for Prediction of Cell Systems…”
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One-step micromolding of complex 3D microchambers for single-cell analysis by Suzuki, Hiroaki, Mitsuno, Kenta, Shiroguchi, Katsuyuki, Tsugane, Mamiko, Okano, Taiji, Dohi, Tetsuji, Tsuji, Tomoaki

“…Herein we examined the extent of replicability of the PDMS microchamber device transferred from the master mold with complex 3D structures fabricated via micro…”
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Myosin V Walks by Lever Action and Brownian Motion by Shiroguchi, Katsuyuki, Kinosita, Kazuhiko Jr

“…Myosin V is a molecular motor that moves cargo along actin filaments. Its two heads, each attached to a long and relatively stiff neck, move alternately…”
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Cbfβ2 deficiency preserves Langerhans cell precursors by lack of selective TGFβ receptor signaling by Tenno, Mari, Shiroguchi, Katsuyuki, Muroi, Sawako, Kawakami, Eiryo, Koseki, Keita, Kryukov, Kirill, Imanishi, Tadashi, Ginhoux, Florent, Taniuchi, Ichiro

“…The mouse Langerhans cell (LC) network is established through the differentiation of embryonic LC precursors. BMP7 and TGFβ1 initiate cellular signaling that…”
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Multiomics Investigation Revealing the Characteristics of HIV-1-Infected Cells In Vivo by Aso, Hirofumi, Nagaoka, Shumpei, Kawakami, Eiryo, Ito, Jumpei, Islam, Saiful, Tan, Benjy Jek Yang, Nakaoka, Shinji, Ashizaki, Koichi, Shiroguchi, Katsuyuki, Suzuki, Yutaka, Satou, Yorifumi, Koyanagi, Yoshio, Sato, Kei

“…For eradication of HIV-1 infection, it is important to elucidate the detailed features and heterogeneity of HIV-1-infected cells in vivo. To reveal multiple…”
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None of the Rotor Residues of F1-ATPase Are Essential for Torque Generation by Chiwata, Ryohei, Kohori, Ayako, Kawakami, Tomonari, Shiroguchi, Katsuyuki, Furuike, Shou, Adachi, Kengo, Sutoh, Kazuo, Yoshida, Masasuke, Kinosita, Kazuhiko

“…F1-ATPase is a powerful rotary molecular motor that can rotate an object several hundred times as large as the motor itself against the viscous friction of…”
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