Search Results - "Shirley, K."
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1
External Control Arms: We're Not on Cruise Control Yet
Published in Clinical pharmacology and therapeutics (01-08-2023)Get full text
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Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology
Published in Nature nanotechnology (01-10-2013)“…In biological fluids, proteins bind to the surface of nanoparticles to form a coating known as the protein corona, which can critically affect the interaction…”
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Analytical models for the perforation of thick and thin thickness woven-laminates subjected to high-velocity impact
Published in Composites. Part B, Engineering (15-06-2018)“…This paper deals with the problem of high-velocity impact of a low-mass projectile on woven composite plates. A nondimensional formulation of two analytical…”
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Impact of injection sites on clinical pharmacokinetics of subcutaneously administered peptides and proteins
Published in Journal of controlled release (10-08-2021)“…For most approved subcutaneously (SC) administered drug products in the US, the recommended injection sites (i.e., abdomen, thigh, and upper arm) are usually…”
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5
Extracellular DNA traps promote thrombosis
Published in Proceedings of the National Academy of Sciences - PNAS (07-09-2010)“…Neutrophil extracellular traps (NETs) are part of the innate immune response to infections. NETs are a meshwork of DNA fibers comprising histones and…”
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Impact of the Nanoparticle–Protein Corona on Colloidal Stability and Protein Structure
Published in Langmuir (26-06-2012)“…In biological fluids, proteins may associate with nanoparticles (NPs), leading to the formation of a so-called “protein corona” largely defining the biological…”
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Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis
Published in ACS nano (27-09-2011)“…In biological fluids, proteins associate with nanoparticles, leading to a protein “corona” defining the biological identity of the particle. However, a…”
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A Tailor-Made Specific Anion-Binding Motif in the Side Chain Transforms a Tetrapeptide into an Efficient Vector for Gene Delivery
Published in Angewandte Chemie International Edition (02-03-2015)“…Arginine‐rich cell‐penetrating peptides are widely utilized as vectors for gene delivery. However, their transfection efficacy still needs to be optimized. To…”
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Numerical study of the simultaneous multiple impact phenomenon on CFRP plates
Published in Composite structures (15-09-2023)“…Composite laminates are currently used in various fields of engineering, in which they can be subjected to multiple impacts, reducing their service life…”
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Combined Oral Contraceptives As Victims of Drug Interactions
Published in Drug metabolism and disposition (01-06-2023)“…Combined oral contraceptives (COCs) are widely used in women of reproductive age in the United States. Metabolism plays an important role in the elimination of…”
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Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex
Published in International journal of cancer (01-04-2010)“…Dietary compounds and epigenetic influences are well recognized factors in cancer progression. Resveratrol (Res), a dietary compound from grapes, has…”
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A Fluorophore‐Labeled Lysine Dendrimer with an Oxo‐Anion‐Binding Motif for Tracking Gene Transfection
Published in Chembiochem : a European journal of chemical biology (01-08-2023)“…A transfection vector based on a peptide dendrimer (1) has been developed and its abilities for DNA binding and transport have been investigated. By attaching…”
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Small Meets Smaller: Effects of Nanomaterials on Microbial Biology, Pathology, and Ecology
Published in ACS nano (24-07-2018)“…As functionalities and levels of complexity in nanomaterials have increased, unprecedented control over microbes has been enabled, as well. In addition to…”
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14
Critical Review of Mouse Models of Venous Thrombosis
Published in Arteriosclerosis, thrombosis, and vascular biology (01-03-2012)“…Deep vein thrombosis and pulmonary embolism are a significant health care concern, representing a major source of mortality and morbidity. In order to…”
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Morphology‐Dependent Cell Imaging by Using a Self‐Assembled Diacetylene Peptide Amphiphile
Published in Angewandte Chemie International Edition (13-11-2017)“…Herein, a novel cationic peptide gemini amphiphile containing diacetylene motifs (DA2P) is presented, which self‐assembles into novel tadpole‐ and bola‐shaped…”
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Quantitative profiling of the protein coronas that form around nanoparticles
Published in Nature protocols (01-09-2014)“…When a nanoparticle enters the bloodstream, proteins bind to it to form a corona that may affect its function. This protein corona can be investigated using…”
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EXOGENOUS Sex Hormones and Sex Hormone Receptor Modulators in COVID‐19: Rationale and Clinical Pharmacology Considerations
Published in Clinical pharmacology and therapeutics (01-03-2022)“…Male patients with coronavirus disease 2019 (COVID‐19) fare much worse than female patients in COVID‐19 severity and mortality according to data from several…”
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Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection
Published in Angewandte Chemie International Edition (11-01-2016)“…Functionalization of the tetracationic cyclic peptide (Ka)4 with a single guanidiniocarbonyl pyrrole (GCP) moiety, a weakly basic but highly efficient arginine…”
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A perovskite-graphene device for X-ray detection
Published in Carbon (New York) (05-01-2024)“…This study examines a perovskite-based graphene field effect transistor (P-GFET) device for X-ray detection. The device architecture consisted of a…”
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From Supramolecular Vesicles to Micelles: Controllable Construction of Tumor‐Targeting Nanocarriers Based on Host–Guest Interaction between a Pillar[5]arene‐Based Prodrug and a RGD‐Sulfonate Guest
Published in Small (Weinheim an der Bergstrasse, Germany) (01-12-2018)“…The targeting ability, drug‐loading capacity, and size of the drug nanocarriers are crucial for enhancing the therapeutic index for cancer therapy. Herein, the…”
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