Search Results - "Shires, Karen"

The use of MAGE C1 and flow cytometry to determine the malignant cell type in multiple myeloma by Wienand, Kirsty, Shires, Karen

“…The malignant cell phenotype of Multiple Myeloma (MM) remains unclear with studies proposing it to be either clonotypic B or proliferating plasma cells…”
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HIV Nef enhances the expression of oncogenic c-MYC and activation-induced cytidine deaminase in Burkitt lymphoma cells, promoting genomic instability by Mdletshe, Nontlantla, Nel, Andrew, Shires, Karen, Mowla, Shaheen

“…Abstract Background Non-Hodgkin lymphoma is of high prevalence among HIV-infected people. In particular, the incidence of HIV-associated Burkitt lymphoma (BL)…”
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The validation of forensic DNA extraction systems to utilize soil contaminated biological evidence by Kasu, Mohaimin, Shires, Karen

“…Highlights • DNA IQ effectively removes HA from highly contaminated blood and saliva. • DNA IQ produces DNA of sufficient quality and quantity to generate full…”
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The expression of multiple cancer/testis antigens can potentially be used to detect circulating disease and clonal evolution in the peripheral blood of multiple myeloma patients by Shires, Karen, Wyk, Teagan Van, Wienand, Kirsty

“…It is thought that cancer/testis antigens (CTAs) are expressed in a cascade-like manner in multiple myeloma as the disease progresses. In this pilot study, we…”
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Abstract B18: MAGEC1 and BAGE2 mRNA expression can be used to monitor chemotherapy treatment responses in multiple myeloma patients and pre-empt clinical relapse by Shires, Karen, Wienand, Kirsty

“…Abstract Being able to monitor the levels of malignant progenitor cells in Multiple Myeloma, as opposed to the plasma cell burden or clinical symptoms alone,…”
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The role of Cancer/Testis Antigens in Multiple Myeloma pathogenesis and their application in disease monitoring and therapy by Shires, Karen, Van Wyk, Teagan

“…[Display omitted] A unique group of genes, encoding tumour associated antigens, known as the Cancer/Testis Antigens (CTAs), have been explored as novel markers…”
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The use of Cancer/Testis antigens to monitor levels of circulating malignant stem cells in Multiple Myeloma by Shires, karen, Wienand, Kirsty

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Cancer testis antigen MAGE C1 can be used to monitor levels of circulating malignant stem cells in the peripheral blood of multiple myeloma patients by Shires, Karen, Wienand, Kirsty

“…Purpose Monitoring the levels of malignant disease-causing cells in multiple myeloma, as opposed to the clinical symptoms alone, is an important move forward…”
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Auditing in the time of COVID – the impact of COVID-19 on auditing in New Zealand and subsequent reforms by Hay, David, Shires, Karen, Van Dyk, Debbie

“…Purpose This special issue paper aims to describe the early effects of COVID-19 on auditing in New Zealand, and the subsequent reforms that the authors expect…”
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Development of a multiplex assay to detect TERC and TERT mutations associated with immunosuppression therapy failure in Aplastic Anaemia patients by Shires, Karen, Xulu, Khethelo, Rust, Adri

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The Use of MAGE C1 and Flow Cytometry to Determine the Malignant Cell Type in Multiple Myeloma: e0120734 by Wienand, Kirsty, Shires, Karen

“…The malignant cell phenotype of Multiple Myeloma (MM) remains unclear with studies proposing it to be either clonotypic B or proliferating plasma cells…”
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Development of a flow cytometric method to detect the presence of mutated nucleophosmin 1 in acute myeloid leukemia by Du Pisani, Louis Almero, Shires, Karen

“…Objective/Background Nucleophosmin 1 (NPM1) plays multiple roles in cell growth and proliferation. Deletion/insertion mutations in exon 12 of NPM1 ( NPM1-DIM…”
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Serine and proline-rich ligands enriched via phage-display technology show preferential binding to BCR/ABL expressing cells by Shires, Karen, Shankland, Iva, Mowla, Shaheen, Njikan, Samuel, Jaymacker, Jai, Novitzky, Nicolas

“…Background and objectives Despite the use of targeted therapy, chronic myelogenous leukemia (CML) currently remains incurable with drug therapy, with patients…”
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Cytogenetically Normal Acute Myeloid Leukaemia at a Single Centre in South Africa by Jenkins, Nicholas, Blanshard, Lee-Ann, Stone, Marian, Verburgh, Estelle, Oosthuizen, Jenna, Shires, Karen

“…The heterogeneous molecular landscape of cytogenetically normal acute myeloid leukemia (CN-AML) renders it an ongoing therapeutic challenge. The European…”
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JAK2/STAT5 Pathway Mutation Frequencies in South African BCR/ABL Negative MPN Patients by Shires, Karen L, Rust, Adriana J, Harryparsad, Rushil, Coburn, Justin A, Gopie, Ruth E

“…Mutations in JAK2/STAT5 proliferation pathway genes are key in the diagnosis of myeloproliferative neoplasms (MPN ), with JAK2V617F being found in 50-97% of…”
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