Search Results - "Shire, Abdirashid M."

Utility of serum immunoglobulin G4 in distinguishing immunoglobulin G4‐associated cholangitis from cholangiocarcinoma by Oseini, Abdul M., Chaiteerakij, Roongruedee, Shire, Abdirashid M., Ghazale, Amaar, Kaiya, Joseph, Moser, Catherine D., Aderca, Ileana, Mettler, Teresa A., Therneau, Terry M., Zhang, Lizhi, Takahashi, Naoki, Chari, Suresh T., Roberts, Lewis R.

“…Elevated serum immunoglobulin G4 (sIgG4) is a feature of autoimmune pancreatitis (AIP) and IgG4‐associated cholangitis (IAC); a >2‐fold increase in sIgG4 is…”
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The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism by Zheng, Xin, Vittar, Natalia B Rumie, Gai, Xiaohong, Fernandez-Barrena, Maite G, Moser, Catherine D, Hu, Chunling, Almada, Luciana L, McCleary-Wheeler, Angela L, Elsawa, Sherine F, Vrabel, Anne M, Shire, Abdirashid M, Comba, Andrea, Thorgeirsson, Snorri S, Kim, Youngsoo, Liu, Qingguang, Fernandez-Zapico, Martin E, Roberts, Lewis R

“…The role of the epithelial-to-mesenchymal transition (EMT) during hepatocellular carcinoma (HCC) progression is well established, however the regulatory…”
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Sulfatase 2 up‐regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma by Lai, Jin‐Ping, Sandhu, Dalbir S., Yu, Chunrong, Han, Tao, Moser, Catherine D., Jackson, Kenard K., Guerrero, Ruben Bonilla, Aderca, Ileana, Isomoto, Hajime, Garrity‐Park, Megan M., Zou, Hongzhi, Shire, Abdirashid M., Nagorney, David M., Sanderson, Schuyler O., Adjei, Alex A., Lee, Ju‐Seog, Thorgeirsson, Snorri S., Roberts, Lewis R.

“…It has been shown that the heparin‐degrading endosulfatase, sulfatase 1 (SULF1), functions as a liver tumor suppressor, but the role of the related sulfatase,…”
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The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3–dependent Wnt activation by Lai, Jin‐Ping, Oseini, Abdul M., Moser, Catherine D., Yu, Chunrong, Elsawa, Sherine F., Hu, Chunling, Nakamura, Ikuo, Han, Tao, Aderca, Ileana, Isomoto, Hajime, Garrity‐Park, Megan M., Shire, Abdirashid M., Li, Jia, Sanderson, Schuyler O., Adjei, Alex A., Fernandez‐Zapico, Martin E., Roberts, Lewis R.

“…Heparan sulfate proteoglycans (HSPGs) act as coreceptors or storage sites for growth factors and cytokines such as fibroblast growth factor and Wnts. Glypican…”
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Highly Methylated Genes in Colorectal Neoplasia: Implications for Screening by Zou, Hongzhi, Harrington, Jonathan J, Shire, Abdirashid M, Rego, Rafaela L, Wang, Liang, Campbell, Megan E, Oberg, Ann L, Ahlquist, David A

“…Discriminant markers are required for accurate cancer screening. We evaluated genes frequently methylated in colorectal neoplasia to identify the most…”
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Occult hepatitis B virus infection: Bit player or role player? by Shire, Abdirashid M., Roberts, Lewis R.

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Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects by Al Qarni, Ali Ahmed, Joatar, Faris Elbahi, Das, Nagalla, Awad, Mohamed, Eltayeb, Mona, Al-Zubair, Ahmed Gasim, Ali, Muhalab E, Al Masaud, Abdulaziz, Shire, Abdirashid M, Gumaa, Khalid, Giha, Hayder A

“…Although the exact mechanism of insulin resistance (IR) has not yet been established, IR is the hallmark characteristic of type 2 diabetes mellitus (T2DM). The…”
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The Tumor Suppressor Function of Human Sulfatase 1 (SULF1) in Carcinogenesis by Lai, Jin-Ping, Sandhu, Dalbir S., Shire, Abdirashid M., Roberts, Lewis R.

“…Introduction Human sulfatase 1 (SULF1) was recently identified and shown to desulfate cellular heparan sulfate proteoglycans (HSPGs). Since sulfated HSPGs…”
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Leu72Met and Other Intronic Polymorphisms in the GHRL and GHSR Genes Are Not Associated with Type 2 Diabetes Mellitus, Insulin Resistance, or Serum Ghrelin Levels in a Saudi Population by Joatar, Faris Elbahi, Al Qarni, Ali Ahmed, Ali, Muhalab E, Al Masaud, Abdulaziz, Shire, Abdirashid M, Das, Nagalla, Gumaa, Khalid, Giha, Hayder A

“…Ghrelin (GHRL), a gastric peptide encoded by the GHRL gene, is known to be involved in energy homeostasis via its G protein receptor, encoded by the growth…”
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Viral Hepatitis Among Somali Immigrants in Minnesota: Association of Hepatitis C With Hepatocellular Carcinoma by Shire, Abdirashid M., PhD, Sandhu, Dalbir S., MBBS, Kaiya, Joseph K., MBChB, Oseini, Abdul M., MD, Yang, Ju Dong, MD, Chaiteerakij, Roongruedee, MD, Mettler, Teresa A., RN, Giama, Nasra H., RN, Roberts, Rosebud O., MBChB, Therneau, Terry M., PhD, Petersen, Gloria M., PhD, Knutson, Keith L., PhD, Roberts, Lewis R., MBChB, PhD

“…Abstract Objective To study the frequencies of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, and their associations with…”
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Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo by Lai, Jin-Ping, Sandhu, Dalbir S, Moser, Catherine D, Cazanave, Sophie C, Oseini, Abdul M, Shire, Abdirashid M, Shridhar, Viji, Sanderson, Schuyler O, Roberts, Lewis R

“…Background/Aims There are limited chemotherapy options for hepatocellular carcinoma (HCC). The heparin-degrading endosulfatase SULF1 functions as a liver tumor…”
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High prevalence of chronic viral hepatitis B and C in Minnesota Somalis contributes to rising hepatocellular carcinoma incidence by Mohamed, Essa A, Giama, Nasra H, Abdalla, Abubaker O, Shaleh, Hassan M, Oseini, Abdul M, Ali, Hamdi A, Ahmed, Fowsiyo, Taha, Wesam, Ahmed Mohammed, Hager, Cvinar, Jessica, Waaeys, Ibrahim A, Ali, Hawa, Allotey, Loretta K, Ali, Abdiwahab O, Mohamed, Safra A, Harmsen, William S, Ahmmad, Eimad M, Bajwa, Numra A, Afgarshe, Mohamud D, Shire, Abdirashid M, Balls-Berry, Joyce E, Roberts, Lewis R

“…Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are known risk factors for liver disease, cirrhosis and hepatocellular carcinoma (HCC)…”
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Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease by Kim, Tae Hyo, Banini, Bubu A, Asumda, Faizal Z, Campbell, Nellie A, Hu, Chunling, Moser, Catherine D, Shire, Abdirashid M, Han, Shaoshan, Ma, Chenchao, Krishnan, Anuradha, Mounajjed, Taofic, White, Thomas A, Gores, Gregory J, LeBrasseur, Nathan K, Charlton, Michael R, Roberts, Lewis Rowland

“…Sulfatase 2 (SULF2) is a heparan sulfate editing enzyme that regulates the milieu of growth factors and cytokines involved in a variety of cellular processes…”
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The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling by Zheng, Xin, Gai, Xiaohong, Han, Shaoshan, Moser, Catherine D., Hu, Chunling, Shire, Abdirashid M., Floyd, Robert A., Roberts, Lewis R.

“…Human sulfatase 2 (SULF2) functions as an oncoprotein in hepatocellular carcinoma (HCC) development by promoting tumor growth and metastasis via enhancement of…”
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Epigenetic DNA hypermethylation in cholangiocarcinoma: potential roles in pathogenesis, diagnosis and identification of treatment targets by Sandhu, Dalbir S., Shire, Abdirashid M., Roberts, Lewis R.

“…Cholangiocarcinomas (CCs) are highly lethal malignant tumours arising from the biliary tract epithelium. The disease is notoriously difficult to diagnose and…”
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299 Expression of SULF2 by HCC Cells Promotes Tumorigenesis by Inducing Activation, Proliferation and Migration of Hepatic Stellate Cells in the Tumor Microenvironment by Han, Shaoshan, Hu, Chunling, Moser, Catherine D, Fang, Yong, Chaiteerakij, Roongruedee, Shire, Abdirashid M, Miamen, Alexander, Yang, Dongye, Thorgeirsson, Snorri, Fernandez-Zapico, Martin E, Roberts, Lewis R

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Ethnic variation in AMD-associated complement factor H polymorphism p.Tyr402His by Grassi, Michael A., Fingert, John H., Scheetz, Todd E., Roos, Benjamin R., Ritch, Robert, West, Sheila K., Kawase, Kazuhide, Shire, Abdirashid M., Mullins, Robert F., Stone, Edwin M.

“…Age‐related macular degeneration (AMD) is the most common cause of irreversible visual loss in the developed world. Previous studies have demonstrated that the…”
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Completion of the human papillomavirus vaccination series lags in Somali adolescents by Pruitt, Crystal N, Reese, Crystal S, Grossardt, Brandon R, Shire, Abdirashid M, Creedon, Douglas J

“…It is unknown whether the Somali population in the United States is likely to participate in human papillomavirus (HPV) vaccination. We aimed to determine…”
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Sulfatase 2 protects hepatocellular carcinoma cells against apoptosis induced by the PI3K inhibitor LY294002 and ERK and JNK kinase inhibitors by Lai, Jin-Ping, Sandhu, Dalbir S., Yu, Chunrong, Moser, Catherine D., Hu, Chunling, Shire, Abdirashid M., Aderca, Ileana, Murphy, Linda M., Adjei, Alex A., Sanderson, Schuyler, Roberts, Lewis R.

“…Background: Sulfatase 2 (SULF2), an extracellular heparan sulphate 6‐O‐endosulphatase, has an oncogenic effect in hepatocellular carcinoma (HCC) that is…”
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805 Knockout of SULF2 Significantly Ameliorates Hypercholesterolemia, Steatohepatitis and Liver Fibrosis in Obese Mice Fed a Fast Food Diet by Kim, Tae Hyo, Hu, Chunling, Shire, Abdirashid M, Moser, Catherine D, Han, Shaoshan, Krishnan, Anuradha, Mounajjed, Taofic, White, Thomas A, Gores, Gregory J, LeBrasseur, Nathan K, Charlton, Michael R, Roberts, Lewis R

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