A descriptive report on short QT interval in Kherameh branch of the PERSIAN cohort study

Short QT-interval is a condition that bear the suspicion of short QT syndrome (SQTS). SQTS is known to increase risk of life-threatening arrythmias and sudden cardiac death (SCD). Due to the insufficient population-based studies and use of various QT cut-off values, it accounts for as an undiagnosed...

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Bibliographic Details
Published in:	Scientific reports Vol. 12; no. 1; p. 2898
Main Authors:	Nikoo, Mohammad Hossein, Heiran, Alireza, Mashayekh, Fardin, Rezaianzadeh, Abbas, Shiravani, Abbas, Azadian, Fatemeh
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 21-02-2022 Nature Publishing Group Nature Portfolio
Subjects:	692/308/174 692/699/75 Adult Aged Arrhythmias, Cardiac - diagnosis Arrhythmias, Cardiac - epidemiology Arrhythmias, Cardiac - genetics Atrial Fibrillation - diagnosis Bradycardia Bradycardia - diagnosis Cardiac arrhythmia Cohort analysis Cohort Studies EKG Electrocardiography Epidemiology Female Fibrillation Heart Rate Humanities and Social Sciences Humans Incidence Iran - epidemiology Male Middle Aged multidisciplinary Population studies Population-based studies Prevalence Science Science (multidisciplinary) Syncope Time Factors Iran
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Summary:	Short QT-interval is a condition that bear the suspicion of short QT syndrome (SQTS). SQTS is known to increase risk of life-threatening arrythmias and sudden cardiac death (SCD). Due to the insufficient population-based studies and use of various QT cut-off values, it accounts for as an undiagnosed condition. In this study, we sought for prevalence of short QT interval in Kherameh cohort study, one of the southern branches of the Prospective Epidemiological Research Studies in Iran (PERSIAN). Data of 4363 adult subjects were analyzed from phase 1 of the cohort during 2014–2017. The corrected QT (QTc) intervals were calculated and electrocardiograms (ECGs) with QTc of less than 370 ms (msec) were reanalyzed for bradycardia, early repolarization, atrial fibrillation (AF), arrhythmias, and other electrical conduction abnormalities. Seventy-two subjects (1.65%) had a QTc of less than 370 ms (mean QTc of 360.72 ± 11.72). A male predominance and a lower mean heart rate observed in SQTS susceptible group (M/F of 1/0.26 vs. 1/1.145, p -value < 0.0001; 58.389 ± 9.787 vs. 70.899 ± 11.775; p -value < 0.0001) compare to the subjects with normal QTc. At least, 2 subjects with high-probability SQTS and 3 with intermediate-probability SQTS identified. The frequency of AF, syncope, bradycardia, early repolarization, low voltage ECG, and infantile SCD in first- and second-degree relatives were 16.67, 4.17, 33.33, 11.11, 11.11, 11.11%, respectively. The prevalence of short QT interval in our cohort was in line with previous studies. The incidence of cardiac symptoms/events, familial SCDs and ECG derived specific findings were high amongst SQTS-susceptible index persons. However, these variables could not predict the symptomatic subjects, which emphasizes gene studies and family screening.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-06835-y