Search Results - "Shiratori, Hidetaka"

The left-right axis in the mouse: from origin to morphology by Shiratori, Hidetaka, Hamada, Hiroshi

“…The past decade or so has seen rapid progress in our understanding of how left-right (LR) asymmetry is generated in vertebrate embryos. However, many important…”
Get full text

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome by Ura, Kiyoe, Kaneda, Yasufumi, Nimura, Keisuke, Shiratori, Hidetaka, Ikawa, Masato, Okabe, Masaru, Schwartz, Robert J

“…Diverse histone modifications are catalysed and recognized by various specific proteins, establishing unique modification patterns that act as transcription…”
Get full text

Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2 by Yoshiba, Satoko, Shiratori, Hidetaka, Kuo, Ivana Y., Kawasumi, Aiko, Shinohara, Kyosuke, Nonaka, Shigenori, Asai, Yasuko, Sasaki, Genta, Belo, Jose Antonio, Sasaki, Hiroshi, Nakai, Junichi, Dworniczak, Bernd, Ehrlich, Barbara E., Pennekamp, Petra, Hamada, Hiroshi

“…Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is…”
Get full text

EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins by Lei, Zili, Maeda, Takako, Tamura, Atsushi, Nakamura, Tetsuya, Yamazaki, Yuji, Shiratori, Hidetaka, Yashiro, Kenta, Tsukita, Sachiko, Hamada, Hiroshi

“…Tight junctions (TJs) connect epithelial cells and form a semipermeable barrier that only allows selective passage of ions and solutes across epithelia. Here…”
Get full text

A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking by Minegishi, Katsura, Hashimoto, Masakazu, Ajima, Rieko, Takaoka, Katsuyoshi, Shinohara, Kyosuke, Ikawa, Yayoi, Nishimura, Hiromi, McMahon, Andrew P., Willert, Karl, Okada, Yasushi, Sasaki, Hiroshi, Shi, Dongbo, Fujimori, Toshihiko, Ohtsuka, Toshihisa, Igarashi, Yasunobu, Yamaguchi, Terry P., Shimono, Akihiko, Shiratori, Hidetaka, Hamada, Hiroshi

“…Polarization of node cells along the anterior-posterior axis of mouse embryos is responsible for left-right symmetry breaking. How node cells become polarized…”
Get full text

Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells by Sai, Xiaorei, Ikawa, Yayoi, Nishimura, Hiromi, Mizuno, Katsutoshi, Kajikawa, Eriko, Katoh, Takanobu A, Kimura, Toshiya, Shiratori, Hidetaka, Takaoka, Katsuyoshi, Hamada, Hiroshi, Minegishi, Katsura

“…For left-right symmetry breaking in the mouse embryo, the basal body must become positioned at the posterior side of node cells, but the precise mechanism for…”
Get full text

Determination of left-right patterning of the mouse embryo by artificial nodal flow by Nonaka, Shigenori, Hamada, Hiroshi, Shiratori, Hidetaka, Saijoh, Yukio

“…Substantial insight has recently been achieved into the mechanisms responsible for the generation of left-right (L-R) asymmetry in the vertebrate body plan…”
Get full text

Two rotating cilia in the node cavity are sufficient to break left–right symmetry in the mouse embryo by Shinohara, Kyosuke, Kawasumi, Aiko, Takamatsu, Atsuko, Yoshiba, Satoko, Botilde, Yanick, Motoyama, Noboru, Reith, Walter, Durand, Bénédicte, Shiratori, Hidetaka, Hamada, Hiroshi

“…Determination of left–right asymmetry in mouse embryos is achieved by a leftward fluid flow (nodal flow) in the node cavity that is generated by clockwise…”
Get full text

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components by Ide, Takahiro, Twan, Wang Kyaw, Lu, Hao, Ikawa, Yayoi, Lim, Lin-Xenia, Henninger, Nicole, Nishimura, Hiromi, Takaoka, Katsuyoshi, Narasimhan, Vijay, Yan, Xiumin, Shiratori, Hidetaka, Roy, Sudipto, Hamada, Hiroshi

“…Motile cilia can beat with distinct patterns, but how motility variations are regulated remain obscure. Here, we have studied the role of the coiled-coil…”
Get full text

Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left–right axis formation by Takao, Daisuke, Nemoto, Tomomi, Abe, Takaya, Kiyonari, Hiroshi, Kajiura-Kobayashi, Hiroko, Shiratori, Hidetaka, Nonaka, Shigenori

“…In the node of mouse embryo, rotational movements of cilia generate an external liquid flow known as nodal flow, which determines left–right asymmetric gene…”
Get full text

An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation by Prall, Owen W.J., Menon, Mary K., Solloway, Mark J., Watanabe, Yusuke, Zaffran, Stéphane, Bajolle, Fanny, Biben, Christine, McBride, Jim J., Robertson, Bronwyn R., Chaulet, Hervé, Stennard, Fiona A., Wise, Natalie, Schaft, Daniel, Wolstein, Orit, Furtado, Milena B., Shiratori, Hidetaka, Chien, Kenneth R., Hamada, Hiroshi, Black, Brian L., Saga, Yumiko, Robertson, Elizabeth J., Buckingham, Margaret E., Harvey, Richard P.

“…During heart development the second heart field (SHF) provides progenitor cells for most cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now…”
Get full text

Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo by Botilde, Yanick, Yoshiba, Satoko, Shinohara, Kyosuke, Hasegawa, Toshiaki, Nishimura, Hiromi, Shiratori, Hidetaka, Hamada, Hiroshi

“…Qilin is one of several genes in zebrafish whose mutation results in cystic kidney. We have now studied the role of its mouse ortholog, Cluap1, in embryonic…”
Get full text

Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm by Dong, Fenglan, Shinohara, Kyosuke, Botilde, Yanick, Nabeshima, Ryo, Asai, Yasuko, Fukumoto, Akemi, Hasegawa, Toshiaki, Matsuo, Moe, Takeda, Hiroyuki, Shiratori, Hidetaka, Nakamura, Tetsuya, Hamada, Hiroshi

“…Axonemal dynein complexes are preassembled in the cytoplasm before their transport to cilia, but the mechanism of this process remains unclear. We now show…”
Get full text

Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo by Kokkinopoulos, Ioannis, Ishida, Hidekazu, Saba, Rie, Ruchaya, Prashant, Cabrera, Claudia, Struebig, Monika, Barnes, Michael, Terry, Anna, Kaneko, Masahiro, Shintani, Yasunori, Coppen, Steven, Shiratori, Hidetaka, Ameen, Torath, Mein, Charles, Hamada, Hiroshi, Suzuki, Ken, Yashiro, Kenta

“…In the early vertebrate embryo, cardiac progenitor/precursor cells (CPs) give rise to cardiac structures. Better understanding their biological character is…”
Get full text

Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs by Shiratori, Hidetaka, Yashiro, Kenta, Shen, Michael M, Hamada, Hiroshi

“…Pitx2 is expressed in developing visceral organs on the left side and is implicated in left-right (LR) asymmetric organogenesis. The asymmetric expression of…”
Get full text

Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters by Nabeshima, Ryo, Nishimura, Osamu, Maeda, Takako, Shimizu, Natsumi, Ide, Takahiro, Yashiro, Kenta, Sakai, Yasuo, Meno, Chikara, Kadota, Mitsutaka, Shiratori, Hidetaka, Kuraku, Shigehiro, Hamada, Hiroshi

“…We have examined the role of , a gene highly expressed in embryonic stem cells, in mouse development. Fam60a interacts with components of the Sin3a-Hdac…”
Get full text

The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo by Sakai, Y, Meno, C, Fujii, H, Nishino, J, Shiratori, H, Saijoh, Y, Rossant, J, Hamada, H

“…Retinoic acid (RA), a derivative of vitamin A, plays a pivotal role in vertebrate development. The level of RA may be determined by the balance between its…”
Get full text

The Mouse Embryo Autonomously Acquires Anterior-Posterior Polarity at Implantation by Takaoka, Katsuyoshi, Yamamoto, Masamichi, Shiratori, Hidetaka, Meno, Chikara, Rossant, Janet, Saijoh, Yukio, Hamada, Hiroshi

“…The earliest recognizable sign of patterning of the mouse embryo along the anteroposterior (A-P) axis is the migration of the distal visceral endoderm (DVE)…”
Get full text

Dysregulation of the PDGFRA gene causes inflow tract anomalies including TAPVR: integrating evidence from human genetics and model organisms by Bleyl, Steven B., Saijoh, Yukio, Bax, Noortje A.M., Gittenberger-de Groot, Adriana C., Wisse, Lambertus J., Chapman, Susan C., Hunter, Jennifer, Shiratori, Hidetaka, Hamada, Hiroshi, Yamada, Shigehito, Shiota, Kohei, Klewer, Scott E., Leppert, Mark F., Schoenwolf, Gary C.

“…Total anomalous pulmonary venous return (TAPVR) is a congenital heart defect inherited via complex genetic and/or environmental factors. We report detailed…”
Get full text

Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis by Takeuchi, Jun K, Ohgi, Makoto, Koshiba-Takeuchi, Kazuko, Shiratori, Hidetaka, Sakaki, Ichiro, Ogura, Keiko, Saijoh, Yukio, Ogura, Toshihiko

“…Extensive misexpression studies were carried out to explore the roles played by Tbx5 , the expression of which is excluded from the right ventricle (RV) during…”
Get full text