Search Results - "Shiramoto, M."

Acid‐inhibitory effects of vonoprazan 20 mg compared with esomeprazole 20 mg or rabeprazole 10 mg in healthy adult male subjects ‐ a randomised open‐label cross‐over study by Sakurai, Y., Mori, Y., Okamoto, H., Nishimura, A., Komura, E., Araki, T., Shiramoto, M.

“…Summary Background Proton pump inhibitors (PPIs) are widely used for the treatment of acid‐related diseases. Vonoprazan is a member of a new class of acid…”
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The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study by Nemoto, O., Furue, M., Nakagawa, H., Shiramoto, M., Hanada, R., Matsuki, S., Imayama, S., Kato, M., Hasebe, I., Taira, K., Yamamoto, M., Mihara, R., Kabashima, K., Ruzicka, T., Hanifin, J., Kumagai, Y.

“…Summary Background The cytokine interleukin‐31 (IL‐31) is considered to be responsible for the development of pruritus in humans. At present, no available…”
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Single-dose new insulin glargine 300U/ml provides prolonged, stable glycaemic control in Japanese and European people with type 1 diabetes by Shiramoto, M, Eto, T, Irie, S, Fukuzaki, A, Teichert, L, Tillner, J, Takahashi, Y, Koyama, M, Dahmen, R, Heise, T, Becker, R H A

“…Aims Two single-dose studies were conducted in Japan and Europe to compare the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of new insulin glargine…”
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Single-dose new insulin glargine 300 U/ml provides prolonged, stable glycaemic control in Japanese and European people with type 1 diabetes by Shiramoto, M., Eto, T., Irie, S., Fukuzaki, A., Teichert, L., Tillner, J., Takahashi, Y., Koyama, M., Dahmen, R., Heise, T., Becker, R. H. A.

“…Aims Two single‐dose studies were conducted in Japan and Europe to compare the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of new insulin glargine…”
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Clock gene expression in peripheral leucocytes of patients with type 2 diabetes by Ando, H, Takamura, T, Matsuzawa-Nagata, N, Shima, K. R, Eto, T, Misu, H, Shiramoto, M, Tsuru, T, Irie, S, Fujimura, A, Kaneko, S

“…Aim/hypothesis Recent studies have demonstrated relationships between circadian clock function and the development of metabolic diseases such as type 2…”
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The Influence of Various Time Points After Standing up on Orthostatic Blood Pressure and Pulse Rate by Furusho, K, Yoshihara, T, Tsukikawa, H, Inada, K, Kimura, M, Melli, A, Chung, E, Shiramoto, M, Matsuki, S, Irie, S

“…Background Clinical trials often measure blood pressure (BP) and pulse rate (PR) in the standing position using drugs with hypotensive effects to exclude…”
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Intragastric PH transition induced by Rabeprazole: investigation of clinical study design by Shiramoto, M, Chung, E, Uchimaru, H, Eto, T, Inoue, M, Tachiki, H, Irie, S

“…Rabeprazole (20 mg) was administered orally as PPI at 19:30 after dinner and at 06:00 the next morning. [...]we evaluated the difference in intragastric pH…”
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Role of nitric oxide in reactive hyperemia in human forearm vessels by TAGAWA, T, IMAIZUMI, T, ENDO, T, SHIRAMOTO, M, HARASAWA, Y, TAKESHITA, A

“…The role of nitric oxide (NO) in reactive hyperemia (RH) is not well known. We investigated whether NO plays a role in RH in human forearm vessels by examining…”
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Role of nitric oxide in exercise-induced vasodilation of the forearm by ENDO, T, IMAIZUMI, T, TAGAWA, T, SHIRAMATO, M, ANDO, S.-I, TAKESHITA, A

“…We wished to determine the role of NO in exercise-induced metabolic forearm vasodilation. Young healthy volunteers (n = 11) underwent static handgrip exercise…”
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Nitric oxide influences neuronal activity in the nucleus tractus solitarius of rat brainstem slices by Tagawa, T, Imaizumi, T, Harada, S, Endo, T, Shiramoto, M, Hirooka, Y, Takeshita, A

“…Nitric oxide (NO) is shown to be synthesized in the central nervous system as well as in vascular endothelial cells. However, the physiological role of NO in…”
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Verinurad combined with febuxostat in Japanese adults with gout or asymptomatic hyperuricaemia: a phase 2a, open-label study by Shiramoto, Masanari, Liu, Sha, Shen, Zancong, Yan, Xiaohong, Yamamoto, Amy, Gillen, Michael, Ito, Yasushi, Hall, Jesse

“…Abstract Objectives Verinurad (RDEA3170) is a high-affinity inhibitor of the URAT1 transporter in clinical development for treating gout and asymptomatic…”
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Vasodilatory effect of arginine vasopressin is mediated by nitric oxide in human forearm vessels by TAGAWA, T, IMAIZUMI, T, ENDO, T, SHIRAMOTO, M, HIROOKA, Y, ANDO, S.-I, TAKESHITA, A

“…Arginine vasopressin (AVP) causes biphasic changes in vascular resistance in human forearms; vasoconstriction at lower doses and vasodilation at higher doses…”
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Transfer function analysis of central arc of aortic baroreceptor reflex in rabbits by Kubo, T, Imaizumi, T, Harasawa, Y, Ando, S, Tagawa, T, Endo, T, Shiramoto, M, Takeshita, A

“…While electrically stimulating the aortic depressor nerve (ADN) pseudorandomly, we recorded renal sympathetic nerve activity (RSNA) and systemic arterial…”
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The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-co by Nemoto, O., Furue, M., Nakagawa, H., Shiramoto, M., Hanada, R., Matsuki, S., Imayama, S., Kato, M., Hasebe, I., Taira, K., Yamamoto, M., Mihara, R., Kabashima, K., Ruzicka, T., Hanifin, J., Kumagai, Y.

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Single‐dose new insulin glargine 300  U/ml provides prolonged, stable glycaemic control in J apanese and E uropean people with type 1 diabetes by Shiramoto, M., Eto, T., Irie, S., Fukuzaki, A., Teichert, L., Tillner, J., Takahashi, Y., Koyama, M., Dahmen, R., Heise, T., Becker, R. H. A.

“…Aims Two single‐dose studies were conducted in J apan and E urope to compare the pharmacokinetic ( PK ) and pharmacodynamic ( PD ) profiles of new insulin…”
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Effects of a novel dihydropyridine calcium antagonist on venous capacitance in Wistar-Kyoto rats by Shiramoto, M, Imaizumi, T, Endo, T, Tagawa, T, Kubo, T, Tokunaga, S, Ando, S, Takeshita, A

“…Calcium antagonists are potent dilators of resistance vessels but do not dilate capacitance vessels. CD832 is a novel dihydropyridine calcium antagonist which…”
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Effects of L-arginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure by HIROOKA, Y, IMAIZUMI, T, TAGAWA, T, SHIRAMOTO, M, ENDO, T, ANDO, S.-I, TAKESHITA, A

“…Endothelium-dependent vasodilation in response to acetylcholine (ACh) and ischemic vasodilation during reactive hyperemia are attenuated in the forearm of…”
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V2 receptor-mediated vasodilation in healthy humans by Tagawa, T, Imaizumi, T, Shiramoto, M, Endo, T, Hironaga, K, Takeshita, A

“…Arginine vasopressin (AVP) causes biphasic changes in vascular resistance in human forearms: vasoconstriction at lower doses and vasodilation at higher doses…”
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Role of nitric oxide towards vasodilator effects of substance P and ATP in human forearm vessels by Shiramoto, M, Imaizumi, T, Hirooka, Y, Endo, T, Namba, T, Oyama, J, Hironaga, K, Takeshita, A

“…1. It has been shown in animals that substance P as well as acetylcholine releases endothelium-derived nitric oxide and evokes vasodilatation and that…”
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Central GABAergic Mechanisms Are Defective in Salt-Induced Hypertension in Borderline Hypertensive Rats by Momohara, Michiko, Imaizumi, Tsutomu, Endo, Toyonari, Suzuki, Satoshi, Tagawa, Tatsuya, Shiramoto, Masanari, Masaki, Hiroyuki, Takeshita, Akira

“…We examined the role of central GABAergic mechanisms in salt-induced hypertension and exaggerated responses to stress in borderline hypertensive rats (BHR),…”
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