Search Results - "Shirakura, Shiro"

Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease by Yamada, Koji, Uchida, Shinichi, Takahashi, Syusuke, Takayama, Makoto, Nagata, Yoshinori, Suzuki, Nobuyuki, Shirakura, Shiro, Kanda, Tomoyuki

“…Abstract Angiotensin-converting enzyme (ACE) inhibitors have clinically been widely used as anti-hypertensive agents. In the present study, we compared the…”
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K-685, a TRPV1 Antagonist, Blocks PKC-Sensitized TRPV1 Activation and Improves the Inflammatory Pain in a Rat Complete Freund’s Adjuvant Model by Sugimoto, Yoshiyuki, Kojima, Yozo, Inayoshi, Atsushi, Inoue, Kazuaki, Miura-Kusaka, Hiroko, Mori, Kiyotoshi, Saku, Osamu, Ishida, Hiroshi, Atsumi, Eri, Nakasato, Yoshisuke, Shirakura, Shiro, Toki, Shin-ichiro, Shinoda, Katsumi, Suzuki, Nobuyuki

“…Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable non-selective cation channel that transmits pain signals. TRPV1 is activated by multiple…”
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Combined Effects of Benidipine and Diltiazem in a Rat Model of Experimental Angina by Yao, Kozo, Shirakura, Shiro

“…We examined the combined effects of the calcium channel blockers 1,4-dihydropyridine (benidipine) and benzothiazepine (diltiazem) on vasopressin-induced…”
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Foam cells generated by a combination of hyperglycemia and hyperlipemia in rats by Sano, Jun-ichi, Shirakura, Shiro, Oda, Shoji, Hara, Takuji, Ishihara, Tokuhiro

“…Diabetes is a major risk factor for atherosclerosis, as well as hyperlipemia. Investigators have suggested that denatured lipoprotein in hyperglycemia…”
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Combined Effects of Benidipine and Diltiazem on Cardiohemodynamics in Anesthetized Dogs by Yao, Kozo, Maeda, Hiroshi, Ina, Yasuhiro, Sato, Miwa, Fujita, Kazuhiro, Kuwabara, Takashi, Kobayashi, Hiroyuki, Shirakura, Shiro

“…We examined the combined effects of the calcium channel blockers 1,4-dihydropyridine (benidipine) and benzothiazepine (diltiazem) on cardiohemodynamics in…”
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Renoprotective Effects of Benidipine in Combination with Angiotensin II Type 1 Receptor Blocker in Hypertensive Dahl Rats by YAO, Kozo, SATO, Hitoshi, INA, Yasuhiro, SUZUKI, Kazuo, OHNO, Tetsuji, SHIRAKURA, Shiro

“…We examined the effects of the angiotensin II type 1 receptor blocker candesartan, the calcium channel blockers benidipine and amlodipine, hydralazine, and the…”
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Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R by Akizuki, Osamu, Inayoshi, Atsushi, Kitayama, Tetsuya, Yao, Kozo, Shirakura, Shiro, Sasaki, Katsutoshi, Kusaka, Hideaki, Matsubara, Masahiro

“…Benidipine, a long-lasting dihydropyridine calcium channel blocker, is used for treatment of hypertension and angina. Benidipine exerts pleiotropic…”
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Discovery of Novel 5,5-Diarylpentadienamides as Orally Available Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists by Saku, Osamu, Ishida, Hiroshi, Atsumi, Eri, Sugimoto, Yoshiyuki, Kodaira, Hiroshi, Kato, Yoshimitsu, Shirakura, Shiro, Nakasato, Yoshisuke

“…We have developed a novel and potent chemical series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we…”
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Effect of Benidipine Hydrochloride (KW-3049), on Cerebral Ischemia Induced by Bilateral Occlusion of the Common Carotid Arteries in Rats by SHIRAKURA, Shiro, KARASAWA, Akira, KUBO, Kazuhiro

“…The effect of benidipine on experimental cerebral ischemia was investigated in rats subjected to occlusion of the bilateral common carotid arteries. Benidipine…”
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Inhibitors of Acyl-CoA : Cholesterol Acyltransferase. II. Preparation and Hypocholesterolemic Activity of Optically Active Dibenz[b, e]oxepin-11-carboxanilides by KUMAZAWA, Toshiaki, YANASE, Masashi, SHIRAKURA, Shiro, OHISHI, Eiko, YAMADA, Koji, MATSUMIYA, Shigeki, KONO, Motomichi

“…In a previous paper, we reported a novel inhibitor of acyl-CoA : cholesterol acyltransferase (ACAT), 2-bromo-N-(2, 6-diisopropylphenyl)-6, 11-dihydrodibenz[b,…”
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Antithrombotic Effects of KW-3635, a Thromboxane A2-Receptor Antagonist, in Guinea Pigs by Shirakura, Shiro, Higo, Katsuya, Takeda, Masami, Karasawa, Akira

“…Antithrombotic effects of KW-3635, a newly synthesized thromboxane (TX) A<SUB2-receptor antagonist, were studied in guinea pigs. In the extracorporeal…”
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Protective effects of benidipine-HCl (KW-3049) against experimental cerebral ischemia and hypoxia by Shirakura, Shiro, Karasawa, Akira, Kubo, Kazuhiro

“…The effects of KW-3049, a new calcium antagonist, on cerebral ischemia, hypoxia and cerebral blood flow were studied. (1) Cerebral ischemia induced by…”
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Effects of KW-3033, a novel ACAT inhibitor, on cholesterol esterification and hyperlipidemia by Shiro Shirakura, Eiko Oh-ishi, Hiroki Ohnuma, Koji Yamada

“…KW-3033 is an (-) optical isomer of KF17828 「2-bromo-N-(2, 6-diisopropylphenyD-6, 11-dihydrodibenz 「b,e」 oxepin-11-carboxamide」 which was found to be a potent…”
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Protective Effect of Benidipine against the Development of Glomerular Sclerosis in Experimental Nephrotic Syndrome by Shirakura, Shiro, Sano, Jun-ichi, Karasawa, Akira, Kubo, Kazuhiro

“…An experimental focal segmental glomerular sclerosis (FSGS) was induced by the combined administration of puromycin aminonucleoside (PAN) and protamine sulfate…”
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Protective Effects of Benidipine on Arachidonic Acid-Induced Acute Cerebral Ischemia in Rats by Shirakura, Shiro, Sano, Jun-ichi, Karasawa, Akira, Kubo, Kazuhiro

“…Acute cerebral ischemia was produced in rats by injection of arachidonic acid (AA) into the internal carotid artery. Evans blue (EB) was intravenously injected…”
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Antithrombotic Effects of KW-3635, a Thromboxane A2-Receptor Antagonist, in Guinea Pigs by Shirakura, Shiro, Higo, Katsuya, Takeda, Masami, Karasawa, Akira

“…Antithrombotic effects of KW-3635, a newly synthesized thromboxane (TX) A2-receptor antagonist, were studied in guinea pigs. In the extracorporeal circulation…”
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N-(1-phenyl-2-benzimidazolyl)- N′-phenylurea derivatives as potent in hibitors of acylcoa:cholesterol acyltransferase (ACAT) by Kumazawa, Toshiaki, Harakawa, Hiroyuki, Fukui, Hiromi, Shirakura, Shiro, Ohishi, Eiko, Yamada, Koji

“…A novel series of N-(1-phenyl-2-benzimidazolyl)- N′-phenylurea derivatives were prepared as ACAT inhibitors. These compounds showed potent ACAT inhibitory…”
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Inhibitors of Acyl-CoA:Cholesterol Acyltransferase. 1. Synthesis and Hypocholesterolemic Activity of Dibenz[b,e]oxepin-11-carboxanilides by Kumazawa, Toshiaki, Yanase, Masashi, Harakawa, Hiroyuki, Obase, Hiroyuki, Shirakura, Shiro, Ohishi, Eiko, Oda, Shoji, Kubo, Kazuhiro, Yamada, Koji

“…A series of N-phenyl-6,11-dihydrodibenz[b,e]oxepin-11-carboxamides and related derivatives were prepared on the basis of structures of the reported inhibitors…”
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Inhibitors of Acyl-CoA by KUMAZAWA, Toshiaki, YANASE, Masashi, SHIRAKURA, Shiro, OHISHI, Eiko, YAMADA, Koji, MATSUMIYA, Shigeki, KONO, Motomichi

“…In a previous paper, we reported a novel inhibitor of acyl-CoA : cholesterol acyltransferase (ACAT), 2-bromo-N-(2, 6-diisopropylphenyl)-6, 11-dihydrodibenz[b,…”
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Insulin-stimulated glucose transport regulated by adenylate cyclase system in rat adipocytes by Shirakura, S, Tokumitsu, Y

“…1. In rat adipocytes, there was an inverse correlation between insulin-stimulated 2-deoxyglucose (2-DG) uptake and cAMP levels, indicating that cAMP suppressed…”
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