Search Results - "Shirakami, Yohei"

Possible Mechanisms of Green Tea and Its Constituents against Cancer by Shirakami, Yohei, Shimizu, Masahito

“…A number of epidemiological, clinical, and experimental researches have indicated that administration of green tea appears to have anti-cancer activity…”
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MicroRNA as a Biomarker in Gastroenterological Cancers by Morishita, Asahiro, Shirakami, Yohei, Okumura, Tomoyuki, Masaki, Tsutomu

“…This Special Issue aims to highlight the usefulness of microRNA (miRNA) as diagnostic and prognostic markers of gastroenterological cancer (GC) [...]…”
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Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis by Miyazaki, Tsuneyuki, Shirakami, Yohei, Mizutani, Taku, Maruta, Akinori, Ideta, Takayasu, Kubota, Masaya, Sakai, Hiroyasu, Ibuka, Takashi, Genovese, Salvatore, Fiorito, Serena, Taddeo, Vito Alessandro, Epifano, Francesco, Tanaka, Takuji, Shimizu, Masahito

“…FXR is a member of the nuclear receptor superfamily and bile acids are endogenous ligands of FXR. FXR activation has recently been reported to inhibit…”
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Hepatic metabolism of retinoids and disease associations by Shirakami, Yohei, Lee, Seung-Ah, Clugston, Robin D., Blaner, William S.

“…The liver is the most important tissue site in the body for uptake of postprandial retinoid, as well as for retinoid storage. Within the liver, both…”
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(–)‐Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor–vascular endothelial growth factor receptor axis by Shirakami, Yohei, Shimizu, Masahito, Adachi, Seiji, Sakai, Hiroyasu, Nakagawa, Takayuki, Yasuda, Yoichi, Tsurumi, Hisashi, Hara, Yukihiko, Moriwaki, Hisataka

“…The receptor tyrosine kinase vascular endothelial growth factor (VEGF) receptor (VEGFR) plays an important role in tumor angiogenesis of hepatocellular…”
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Cancer chemoprevention with green tea catechins: from bench to bed by Shirakami, Yohei, Shimizu, Masahito, Moriwaki, Hisataka

“…Many epidemiological studies and a large number of experimental studies using a variety of animal models have observed that consumption or administration of…”
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The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice by Ideta, Takayasu, Shirakami, Yohei, Miyazaki, Tsuneyuki, Kochi, Takahiro, Sakai, Hiroyasu, Moriwaki, Hisataka, Shimizu, Masahito

“…Non-alcoholic fatty liver disease (NAFLD), which is strongly associated with metabolic syndrome, is increasingly a major cause of hepatic disorder. Dipeptidyl…”
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High-Fat Diet Delays Liver Fibrosis Recovery and Promotes Hepatocarcinogenesis in Rat Liver Cirrhosis Model by Taguchi, Daisuke, Shirakami, Yohei, Sakai, Hiroyasu, Maeda, Toshihide, Miwa, Takao, Kubota, Masaya, Imai, Kenji, Ibuka, Takashi, Shimizu, Masahito

“…More effective treatments for hepatitis viral infections have led to a reduction in the incidence of liver cirrhosis. A high-fat diet can lead to chronic…”
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Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats by Shirakami, Yohei, Nakanishi, Takayuki, Ozawa, Noritaka, Ideta, Takayasu, Kochi, Takahiro, Kubota, Masaya, Sakai, Hiroyasu, Ibuka, Takashi, Tanaka, Takuji, Shimizu, Masahito

“…Prostaglandin E2 receptor EP4 is involved in inflammation and related tumorigenesis in the colorectum. This study aimed to investigate the chemopreventive…”
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Alpha-Glucosidase Inhibitor Voglibose Suppresses Azoxymethane-Induced Colonic Preneoplastic Lesions in Diabetic and Obese Mice by Kato, Junichi, Shirakami, Yohei, Mizutani, Taku, Kubota, Masaya, Sakai, Hiroyasu, Ibuka, Takashi, Shimizu, Masahito

“…Type 2 diabetes mellitus and its related insulin resistance are known to increase the risk of cancer. Anti-diabetic agents can improve insulin resistance and…”
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Animal naming test stratifies the risk of falls and fall-related fractures in patients with cirrhosis by Miwa, Takao, Hanai, Tatsunori, Hirata, Sachiyo, Nishimura, Kayoko, Unome, Shinji, Nakahata, Yuki, Imai, Kenji, Shirakami, Yohei, Suetsugu, Atsushi, Takai, Koji, Shimizu, Masahito

“…This study aimed to determine the relationship between animal naming test (ANT), falls, and fall-related fractures in patients with cirrhosis. Cognitive…”
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Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic mice by Obara, Koki, Shirakami, Yohei, Maruta, Akinori, Ideta, Takayasu, Miyazaki, Tsuneyuki, Kochi, Takahiro, Sakai, Hiroyasu, Tanaka, Takuji, Seishima, Mitsuru, Shimizu, Masahito

“…Sodium glucose cotransporter 2 inhibitors are expected to ameliorate the abnormalities associated with metabolic syndrome including non-alcoholic fatty liver…”
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Editorial: Cancer and nutrients: new chemicals, signals, and biomarker-based therapy by Qin, Xian-Yang, Mendoza-Parra, Marco Antonio, Shirakami, Yohei

“…Editorial on the Research Topic Cancer and nutrients: new chemicals, signals, and biomarker-based therapy Nutrients such as vitamins, minerals, fats, and amino…”
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A Novel Mouse Model of Intrahepatic Cholangiocarcinoma Induced by Azoxymethane by Shirakami, Yohei, Kato, Junichi, Ohnishi, Masaya, Taguchi, Daisuke, Maeda, Toshihide, Ideta, Takayasu, Kubota, Masaya, Sakai, Hiroyasu, Tomita, Hiroyuki, Tanaka, Takuji, Shimizu, Masahito

“…Cholangiocarcinoma is the second most common primary cancer of the liver and has a poor prognosis. Various animal models, including carcinogen-induced and…”
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Suppressive effects of the sodium‑glucose cotransporter 2 inhibitor tofogliflozin on colorectal tumorigenesis in diabetic and obese mice by Kato, Junichi, Shirakami, Yohei, Ohnishi, Masaya, Mizutani, Taku, Kubota, Masaya, Sakai, Hiroyasu, Ibuka, Takashi, Tanaka, Takuji, Shimizu, Masahito

“…Sodium‑glucose cotransporter 2 inhibitors were developed for the treatment of diabetes mellitus. Although recent studies have indicated that sodium‑glucose…”
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Pitavastatin inhibits azoxymethane‐induced colonic preneoplastic lesions in C57BL/KsJ‐db/db obese mice by Yasuda, Yoichi, Shimizu, Masahito, Shirakami, Yohei, Sakai, Hiroyasu, Kubota, Masaya, Hata, Kazuya, Hirose, Yoshinobu, Tsurumi, Hisashi, Tanaka, Takuji, Moriwaki, Hisataka

“…Obesity and related metabolic abnormalities are risk factors for colorectal cancer. A state of chronic inflammation and adipocytokine imbalance may play a role…”
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Dietary supplementation with branched‐chain amino acids suppresses diethylnitrosamine‐induced liver tumorigenesis in obese and diabetic C57BL/KsJ‐db/db mice by Iwasa, Junpei, Shimizu, Masahito, Shiraki, Makoto, Shirakami, Yohei, Sakai, Hiroyasu, Terakura, Yoichi, Takai, Koji, Tsurumi, Hisashi, Tanaka, Takuji, Moriwaki, Hisataka

“…Obesity and related metabolic abnormalities, including insulin resistance, are risk factors for hepatocellular carcinoma in non‐alcoholic steatohepatitis as…”
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Non-alcoholic steatohepatitis and preneoplastic lesions develop in the liver of obese and hypertensive rats: Suppressing effects of EGCG on the development of liver lesions by Kochi, Takahiro, Shimizu, Masahito, Terakura, Daishi, Baba, Atsushi, Ohno, Tomohiko, Kubota, Masaya, Shirakami, Yohei, Tsurumi, Hisashi, Tanaka, Takuji, Moriwaki, Hisataka

“…Highlights • We examined the effects of EGCG on the hepatotumorigenesis in SHRSP-ZF rats treated with HFD and CCl4. • SHRSP-ZF rats presented with features of…”
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Prevention of Colorectal Cancer by Targeting Obesity-Related Disorders and Inflammation by Shirakami, Yohei, Ohnishi, Masaya, Sakai, Hiroyasu, Tanaka, Takuji, Shimizu, Masahito

“…Colorectal cancer is a major healthcare concern worldwide. Many experimental and clinical studies have been conducted to date to discover agents that help in…”
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Targeting receptor tyrosine kinases for chemoprevention by green tea catechin, EGCG by Shimizu, Masahito, Shirakami, Yohei, Moriwaki, Hisataka

“…Tea is one of the most popular beverages consumed worldwide. Epidemiologic studies show an inverse relationship between consumption of tea, especially green…”
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