Search Results - "Shiraishi, Taro"

Recent advances in the biosynthesis of nucleoside antibiotics by Shiraishi, Taro, Kuzuyama, Tomohisa

“…Nucleoside antibiotics are a diverse class of natural products with promising biomedical activities. These compounds contain a saccharide core and a…”
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Biosynthetic pathways and enzymes involved in the production of phosphonic acid natural products by Shiraishi, Taro, Kuzuyama, Tomohisa

“…Phosphonates are organophosphorus compounds possessing a characteristic C-P bond in which phosphorus is directly bonded to carbon. As phosphonates mimic the…”
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Biosynthesis of the nucleoside antibiotic angustmycins: identification and characterization of the biosynthetic gene cluster reveal unprecedented dehydratase required for exo-glycal formation by Shiraishi, Taro, Xia, Jiaqi, Kato, Teruhito, Kuzuyama, Tomohisa

“…The nucleoside antibiotic angustmycin, produced by some Streptomyces strains, is composed of adenine and C 6 sugar and shows antibiotic and antitumor…”
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Discovery of type II polyketide synthase-like enzymes for the biosynthesis of cispentacin by Hibi, Genki, Shiraishi, Taro, Umemura, Tatsuki, Nemoto, Kenji, Ogura, Yusuke, Nishiyama, Makoto, Kuzuyama, Tomohisa

“…Type II polyketide synthases (PKSs) normally synthesize polycyclic aromatic compounds in nature, and the potential to elaborate further diverse skeletons was…”
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Total Synthesis and Stereochemistry Assignment of Nucleoside Antibiotic A‐94964 by Shao, Xiaofei, Zheng, Chang, Xu, Peng, Shiraishi, Taro, Kuzuyama, Tomohisa, Molinaro, Antonio, Silipo, Alba, Yu, Biao

“…A collective total synthesis of eight diastereoisomers associated with NMR analysis leads to a full stereochemistry assignment of the structurally unique…”
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Frequency and component analysis of contaminants generated in preparation of anticancer agents using closed system drug transfer devices (CSTDs) by Sumikawa, Satomi, Yakushijin, Yoshihiro, Aogi, Kenjiro, Yano, Takuya, Hiroki, Hashimoto, Tsukui, Chiyuki, Noguchi, Tadashi, Shiraishi, Taro, Horikawa, Yasuhiro, Yasuoka, Yasuo, Tanaka, Akihiro, Hidaka, Noriaki, Tanaka, Mamoru

“…Occupational exposure of anticancer agents during their preparation has been recognized as a serious hazard. Closed system drug transfer devices (CSTDs) enable…”
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The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2‑Aminopurinyl Peptidyl Nucleoside Antibiotics by Romo, Anthony J, Shiraishi, Taro, Ikeuchi, Hideo, Lin, Geng-Min, Geng, Yujie, Lee, Yu-Hsuan, Liem, Priscilla H, Ma, Tianlu, Ogasawara, Yasushi, Shin-ya, Kazuo, Nishiyama, Makoto, Kuzuyama, Tomohisa, Liu, Hung-wen

“…Peptidyl nucleoside antibiotics (PNAs) are a diverse class of natural products with promising biomedical activities. These compounds have tripartite structures…”
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Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces by Hasebe, Fumihito, Matsuda, Kenichi, Shiraishi, Taro, Futamura, Yushi, Nakano, Takeshi, Tomita, Takeo, Ishigami, Ken, Taka, Hikari, Mineki, Reiko, Fujimura, Tsutomu, Osada, Hiroyuki, Kuzuyama, Tomohisa, Nishiyama, Makoto

“…Vzb22, an amino-group carrier protein from Streptomyces , is required for biosynthesis of the noncanonical amino acid DADH, a biosynthetic precursor of…”
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Identification and heterologous expression of the actinoallolide biosynthetic gene cluster by Inahashi, Yuki, Shiraishi, Taro, Také, Akira, Matsumoto, Atsuko, Takahashi, Yōko, Ōmura, Satoshi, Kuzuyama, Tomohisa, Nakashima, Takuji

“…Actinoallolides are anti-trypanosomal macrolides isolated from the secondary metabolites of two endophytic actinomycete strains, Actinoallomurus fulvus…”
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Biosynthesis of Trehangelin in Polymorphospora rubra K07-0510: Identification of Metabolic Pathway to Angelyl-CoA by Inahashi, Yuki, Shiraishi, Taro, Palm, Kaia, Takahashi, Yoko, Ōmura, Satoshi, Kuzuyama, Tomohisa, Nakashima, Takuji

“…Trehangelins are trehalose angelates discovered from endophytic actinomycete Polymorphospora rubra K07‐0510. We identified the trehangelin biosynthetic gene…”
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Fosfomycin Biosynthesis via Transient Cytidylylation of 2‑Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme by Cho, Su-Hee, Kim, Seung-Young, Tomita, Takeo, Shiraishi, Taro, Park, Jin-Soo, Sato, Shusuke, Kudo, Fumitaka, Eguchi, Tadashi, Funa, Nobutaka, Nishiyama, Makoto, Kuzuyama, Tomohisa

“…Fosfomycin is a wide-spectrum phosphonate antibiotic that is used clinically to treat cystitis, tympanitis, etc. Its biosynthesis starts with the formation of…”
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Biosynthesis of the antituberculous agent caprazamycin: Identification of caprazol-3ʺ-phosphate, an unprecedented caprazamycin-related metabolite by Shiraishi, Taro, Hiro, Noboru, Igarashi, Masayuki, Nishiyama, Makoto, Kuzuyama, Tomohisa

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In vivo and in vitro reconstitution of biosynthesis of N-prenylated phenazines revealing diverse phenazine-modifying enzymes by Kato, Teruhito, Xia, Dan, Ozaki, Taro, Nakao, Tomoyo, Zhao, Ping, Nishiyama, Makoto, Shiraishi, Taro, Kuzuyama, Tomohisa

“…Phenazine natural products play various roles such as signal molecules, antibiotics, or electron carriers in their producer strains. Among these products,…”
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Complete Biosynthetic Pathway of the Phosphonate Phosphonothrixin: Two Distinct Thiamine Diphosphate-Dependent Enzymes Divide the Work to Form a C–C Bond by Zhu, Yuxun, Shiraishi, Taro, Lin, Jianwen, Inaba, Keito, Ito, Atsuro, Ogura, Yusuke, Nishiyama, Makoto, Kuzuyama, Tomohisa

“…Phosphonates often exhibit biological activities by mimicking the phosphates and carboxylates of biological molecules. The phosphonate phosphonothrixin (PTX),…”
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Efficient anti-tumor effect of photodynamic treatment with polymeric nanoparticles composed of polyethylene glycol and polylactic acid block copolymer encapsulating hydrophobic porphyrin derivative by Ogawara, Ken-ichi, Shiraishi, Taro, Araki, Tomoya, Watanabe, Taka-ichi, Ono, Tsutomu, Higaki, Kazutaka

“…To develop potent and safer formulation of photosensitizer for cancer photodynamic therapy (PDT), we tried to formulate hydrophobic porphyrin derivative,…”
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Total Synthesis and Stereochemistry Assignment of Nucleoside Antibiotic A‐94964 by Shao, Xiaofei, Zheng, Chang, Xu, Peng, Shiraishi, Taro, Kuzuyama, Tomohisa, Molinaro, Antonio, Silipo, Alba, Yu, Biao

“…A collective total synthesis of eight diastereoisomers associated with NMR analysis leads to a full stereochemistry assignment of the structurally unique…”
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Biosynthesis of the antituberculous agent caprazamycin by Shiraishi, Taro, Hiro, Noboru, Igarashi, Masayuki, Nishiyama, Makoto, Kuzuyama, Tomohisa

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