Search Results - "Shirahata, A."

DNA Interaction with Antitumor Polyamine Analogues: A Comparison with Biogenic Polyamines by N’soukpoé-Kossi, C. N, Ouameur, A. Ahmed, Thomas, T, Shirahata, A, Thomas, T. J, Tajmir-Riahi, H. A

“…Biogenic polyamines, putrescine, spermidine, and spermine, are ubiquitous cellular cations and exert multiple biological functions. Polyamine analogues mimic…”
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A phase III clinical trial of a mixture agent of plasma‐derived factor VIIa and factor X (MC710) in haemophilia patients with inhibitors by Shinkoda, Y., Shirahata, A., Fukutake, K., Takamatsu, J., Shima, M., Hanabusa, H., Mugishima, H., Takedani, H., Kawasugi, K., Taki, M., Matsushita, T., Tawa, A., Nogami, K., Higasa, S., Kosaka, Y., Fujii, T., Sakai, M., Migita, M., Uchiba, M., Kawakami, K., Sameshima, K., Ohashi, Y., Saito, H.

“…Introduction MC710, a 1:10 protein weight ratio mixture of plasma‐derived activated factor VII (FVIIa) and factor X (FX), is a novel bypassing agent for…”
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Paediatric presentation and outcome of congenital protein C deficiency in Japan by Ohga, S., Kang, D., Kinjo, T., Ochiai, M., Doi, T., Ishimura, M., Kayamori, Y., Urata, M., Yamamoto, J., Suenobu, S.-I., Kanegane, H., Ikenoue, T., Shirahata, A., Hara, T.

“…Summary Severe heritable protein C (PC) deficiency is quite rare, although heterozygous PROC mutation is the second leading cause of genetic predisposition to…”
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DNA Condensation by Polyamines:  A Laser Light Scattering Study of Structural Effects by Vijayanathan, Veena, Thomas, Thresia, Shirahata, Akira, Thomas, T. J

“…Polyamines such as spermidine and spermine are abundant in living cells and are believed to aid in the dense packaging of cellular DNA. DNA condensation is a…”
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Current situation of regular replacement therapy (prophylaxis) for haemophilia in Japan by TAKI, M., SHIRAHATA, A.

“…We conducted a questionnaire survey of haemophilia treaters participating in the Fourth Seminar on Regular Replacement Therapy (sponsored by Baxter Bioscience,…”
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Enhancement of intestinal absorption of macromolecules by spermine in rats by Sugita, Y, Takao, K, Toyama, Y, Shirahata, A

“…The aim of this study was to investigate the enhancing effect of polyamines on intestinal absorption of fluorescein isothiocyanate-labeled dextran (MW 4400,…”
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A Phase II clinical trial of a mixture of plasma-derived factor VIIa and factor X (MC710) in haemophilia patients with inhibitors: haemostatic efficacy, safety and pharmacokinetics/pharmacodynamics by Shirahata, A., Fukutake, K., Takamatsu, J., Shima, M., Hanabusa, H., Mugishima, H., Amano, K., Takedani, H., Tamashima, S., Matsushita, T., Tawa, A., Tanaka, I., Higasa, S., Kosaka, Y., Fujii, T., Sakai, M., Migita, M., Kawakami, K., Ohashi, Y., Saito, H.

“…Summary MC710, a mixture of plasma‐derived activated factor VII and factor X at a protein weight ratio of 1:10, is a novel bypassing agent for haemostasis in…”
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Results of clot waveform analysis and thrombin generation test for a plasma-derived factor VIIa and X mixture (MC710) in haemophilia patients with inhibitors-phase I trial: 2nd report by Shirahata, A., Fukutake, K., Mimaya, J., Takamatsu, J., Shima, M., Hanabusa, H., Takedani, H., Takashima, Y., Matsushita, T., Tawa, A., Higasa, S., Takata, N., Sakai, M., Kawakami, K., Ohashi, Y., Saito, H.

“…Summary We reported the results of a clinical pharmacological study of MC710 (a mixture of plasma‐derived FVIIa and FX) in haemophilia patients with inhibitors…”
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An analysis of factors affecting the incidence of inhibitor formation in patients with congenital haemophilia in Japan by SHIRAHATA, A., FUKUTAKE, K., HIGASA, S., MIMAYA, J., OKA, T., SHIMA, M., TAKAMATSU, J., TAKI, M., TANEICHI, M., YOSHIOKA, A.

“…Studies conducted in European and North American countries have demonstrated that various factors including races affect the frequency of inhibitor formation…”
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Clinical pharmacological study of a plasma-derived factor VIIa and factor X mixture (MC710) in haemophilia patients with inhibitors - Phase I trial by SHIRAHATA, A., FUKUTAKE, K., MIMAYA, J., TAKAMATSU, J., SHIMA, M., HANABUSA, H., TAKEDANI, H., TAKASHIMA, Y., MATSUSHITA, T., TAWA, A., HIGASA, S., TAKATA, N., SAKAI, M., KAWAKAMI, K., OHASHI, Y., SAITO, H.

“…MC710, a combined product of plasma‐derived activated factor VII (FVIIa) and factor X (FX) at a protein weight ratio of 1:10, is a novel bypassing agent for…”
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Clinical evaluation of recombinant factor VIII preparation (Kogenate) in previously treated patients with Hemophilia A : Descriptive meta-analysis of post-marketing study data by YOSHIOKA, A, FUKUTAKE, K, TAKAMATSU, J, SHIRAHATA, A

“…The safety and efficacy of Kogenate, a recombinant factor VIII (rFVIII) preparation for the treatment of bleeding episodes, were studied in a 123-patient…”
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Clinical evaluation of a recombinant factor VIII preparation (Kogenate) in previously untreated patients with hemophilia A by YOSHIOKA, A, FUKUTAKE, K, TAKAMATSU, J, SHIRAHATA, A

“…The safety and efficacy of a recombinant factor VIII (rFVIII) preparation (Kogenate) for the treatment of bleeding episodes was studied in previously untreated…”
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Successful steroid pulse treatment in childhood acquired haemophilia with nephrotic syndrome by Sakai, M., Shima, M., Shirahata, A.

“…We encountered a 2‐year‐old boy with acquired haemophilia, which rarely occurs in children, who was complicated with nephrotic syndrome. In mid‐August 2001, he…”
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Identification of the Putrescine Recognition Site on Polyamine Transport Protein PotE by Kashiwagi, Keiko, Kuraishi, Aiko, Tomitori, Hideyuki, Igarashi, Atsuko, Nishimura, Kazuhiro, Shirahata, Akira, Igarashi, Kazuei

“…The PotE protein can catalyze both uptake and excretion of putrescine. The Km values of putrescine for uptake and excretion are 1.8 and 73 μm, respectively…”
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Intracranial hemorrhage in children with immune thrombocytopenic purpura by IYORI, H, BESSHO, F, OOKAWA, H, KONISHI, S, SHIRAHATA, A, MIYAZAKI, S, FUJISAWA, K, AKATSUKA, J

“…We sent questionnaires to hospitals in Japan in order to study the incidence and conditions of intracranial hemorrhage (ICH) in children with immune…”
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A Molecular Beacon Strategy for the Thermodynamic Characterization of Triplex DNA:  Triplex Formation at the Promoter Region of Cyclin D1 by Antony, Thomas, Thomas, Thresia, Sigal, Leonard H, Shirahata, Akira, Thomas, T. J

“…We studied the formation of triplex DNA in the purine−pyrimidine-rich promoter site sequence of cyclin D1, located at −116 to −99 from the transcription…”
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Hepatobiliary and pancreatic disorders as risk factors for fat-soluble vitamin deficiencies by Shirahata, A

“…The aim of this article is to describe the fat-soluble vitamin status in patients with hepatobiliary and pancreatic diseases, and the contribution of these…”
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Vitamin K group by Shirahata, A

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Safety and efficacy of a new recombinant FVIII formulated with sucrose (rFVIII-FS) in patients with haemophilia A: a long-term, multicentre clinical study in Japan by Yoshioka, A., Shima, M., Fukutake, K., Takamatsu, J., Shirahata, A.

“…The recombinant full‐length FVIII product Kogenate® has been reformulated using sucrose (rFVIII–FS) instead of human serum albumin as a stabiliser in…”
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Effects of natural and synthetic polyamines on the conformation of an oligodeoxyribonucleotide with the estrogen response element by Thomas, Thresia, Kulkarni, Gayathri D., Gallo, Michael A., Greenfield, Norma, Lewis, Joan S., Shirahata, Akira, Thomas, T. J.

“…We studied the effects of natural and synthetic polyamines on the conformation of an oligodeoxyribonucleotide (ODN1) harboring the estrogen response element…”
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