Search Results - "Shipston, M. J."

Cerebellar Ataxia and Purkinje Cell Dysfunction Caused by Ca2+-Activated K+Channel Deficiency by Sausbier, M., Hu, H., Arntz, C., Feil, S., Kamm, S., Adelsberger, H., Sausbier, U., Sailer, C. A., Feil, R., Hofmann, F., Korth, M., Shipston, M. J., H.-G. Knaus, Wolfer, D. P., Pedroarena, C. M., Storm, J. F., Ruth, P., Andersen, Per O.

“…Malfunctions of potassium channels are increasingly implicated as causes of neurological disorders. However, the functional roles of the large-conductance…”
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BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells by Düfer, M., Neye, Y., Hörth, K., Krippeit-Drews, P., Hennige, A., Widmer, H., McClafferty, H., Shipston, M. J., Häring, H.-U., Ruth, P., Drews, G.

“…Aims/hypothesis Evidence is accumulating that Ca 2+ -regulated K + (K Ca ) channels are important for beta cell function. We used BK channel knockout (BK-KO)…”
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Multi‐dimensional time‐correlated single photon counting (TCSPC) fluorescence lifetime imaging microscopy (FLIM) to detect FRET in cells by DUNCAN, R. R., BERGMANN, A., COUSIN, M. A., APPS, D. K., SHIPSTON, M. J.

“…Summary We present a novel, multi‐dimensional, time‐correlated single photon counting (TCSPC) technique to perform fluorescence lifetime imaging with a…”
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Characterization of BK channel splice variants using membrane potential dyes by Saleem, F, Rowe, ICM, Shipston, MJ

“…Background and purpose:  Large conductance calcium‐ and voltage‐activated potassium (BK) channels are encoded by a single gene that displays extensive pre‐mRNA…”
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Alternative splicing of potassium channels: a dynamic switch of cellular excitability by Shipston, Michael J.

“…Alternative splicing of pre-messenger RNA and reversible protein phosphorylation are fundamental mechanisms for regulating protein structure and function…”
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Posttranscriptional and Posttranslational Regulation of BK Channels by Shipston, M J, Tian, L

“…Large conductance calcium- and voltage-activated potassium (BK) channels are ubiquitously expressed and play an important role in the regulation of an eclectic…”
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BK Channels and the Control of the Pituitary by Duncan, P J, Shipston, M J

“…The pituitary gland provides the important link between the nervous system and the endocrine system and regulates a diverse range of physiological functions…”
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Modulating patterned adhesion and repulsion of HEK 293 cells on microengineered parylene-C/SiO2 substrates by Hughes, M. A., Bunting, A. S., Cameron, K., Murray, A. F., Shipston, M. J.

“…This article describes high resolution patterning of HEK 293 cells on a construct of micropatterned parylene‐C and silicon dioxide. Photolithographic…”
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Activation of protein kinase C inhibits calcium-activated potassium channels in rat pituitary tumour cells by Shipston, M J, Armstrong, D L

“…1. The regulation of large-conductance, calcium- and voltage-dependent potassium (BK) channels by protein kinase C (PKC) was investigated in clonal rat…”
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Red, yellow, green go!--A novel tool for microscopic segregation of secretory vesicle pools according to their age by Wiegand, U K, Duncan, R R, Greaves, J, Chow, R H, Shipston, M J, Apps, D K

“…Large dense-core vesicles (LDCVs) were labelled in cultured bovine adrenal chromaffin cells expressing fluorescent chimaeric 'cargo' proteins that were…”
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Depolarization counteracts glucocorticoid inhibition of adenohypophysical corticotroph cells by Lim, M C, Shipston, M J, Antoni, F A

“…In AtT20 mouse corticotroph tumour cells large conductance Ca2+‐activated K+‐channels (BK‐channels) have an essential role in the early glucocorticoid…”
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Pituitary corticotrope tumor (AtT20) cells as a model system for the study of early inhibition by glucocorticoids by Woods, M D, Shipston, M J, Mullens, E L, Antoni, F A

“…The utility of the established ACTH secreting mouse pituitary tumor cell line AtT20 for investigating early glucocorticoid inhibition was examined. Three…”
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Inactivation of early glucocorticoid feedback by corticotropin-releasing factor in vitro by Shipston, M J, Antoni, F A

“…We have investigated the interaction between hypothalamic ACTH secretagogues and adrenocortical glucocorticoids in rat anterior pituitary tissue using an in…”
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Alternative Splicing Switches Potassium Channel Sensitivity to Protein Phosphorylation by Tian, Lijun, Duncan, Rory R., Hammond, Martin S.L., Coghill, Lorraine S., Wen, Hua, Rusinova, Radda, Clark, Alan G., Levitan, Irwin B., Shipston, Michael J.

“…Alternative exon splicing and reversible protein phosphorylation of large conductance calcium-activated potassium (BK) channels represent fundamental control…”
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Early glucocorticoid feedback in anterior pituitary corticotrophs: differential inhibition of hormone release induced by vasopressin and corticotrophin-releasing factor in vitro by Shipston, M J, Antoni, F A

“…Vasopressin and 41-residue corticotrophin-releasing factor (CRF-41) are physiological mediators of the hypothalamic control of pituitary ACTH secretion, whilst…”
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Is double C2 protein (DOC2) expressed in bovine adrenal medulla? A commercial anti-DOC2 monoclonal antibody recognizes a major bovine mitochondrial antigen by Duncan, R R, Apps, D K, Learmonth, M P, Shipston, M J, Chow, R H

“…We have examined the expression in bovine adrenal medulla of double C2 protein (DOC2), a vesicular protein which associates with intracellular phospholipid and…”
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Inhibitory role for calcineurin in stimulus-secretion coupling revealed by FK506 and cyclosporin A in pituitary corticotrope tumor cells by Antoni, F A, Shipston, M J, Smith, S M

“…The properties of the calcium/calmodulin-dependent protein phosphatase calcineurin and its potential role in stimulus-secretion coupling were examined in AtT20…”
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Early glucocorticoid induction of calmodulin and its suppression by corticotropin-releasing factor in pituitary corticotrope tumor (AtT20) cells by Shipston, M J, Antoni, F A

“…Glucocorticoids inhibit stimulus-evoked ACTH secretion by the rapid induction of new protein(s) that suppress intracellular free calcium signals. The present…”
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Mechanism(s) of early glucocorticoid inhibition of adrenocorticotropin secretion from anterior pituitary corticotropes by Shipston, Michael J.

“…Adrenal glucocorticoid hormones, released in response to stress activation of the hypothalamic-pituitary-adrenal axis (HPA), are powerful regulators of…”
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Alternative splicing determines sensitivity of murine calcium-activated potassium channels to glucocorticoids by Tian, Lijun, Hammond, Martin S. L., Florance, Hannah, Antoni, Ferenc A., Shipston, Michael J.

“…Large-conductance Ca 2+ - and voltage-activated potassium (BK) channels are important regulators of cellular excitability. Here, we present a patch-clamp…”
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