Search Results - "Shiokawa, Zenyu"

Discovery of a Novel Scaffold as an Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, Longamide B by Shiokawa, Zenyu, Kashiwabara, Emi, Yoshidome, Daisuke, Fukase, Koichi, Inuki, Shinsuke, Fujimoto, Yukari

“…Indoleamine 2,3‐dioxygenase 1 (IDO1) has emerged as a key target for cancer therapy, as IDO1 plays a critical role in the capacity of tumor cells to evade the…”
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Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility by Ohashi, Tomohiro, Oguro, Yuya, Tanaka, Toshio, Shiokawa, Zenyu, Tanaka, Yuta, Shibata, Sachio, Sato, Yoshihiko, Yamakawa, Hiroko, Hattori, Harumi, Yamamoto, Yukiko, Kondo, Shigeru, Miyamoto, Maki, Nishihara, Mitsuhiro, Ishimura, Yoshimasa, Tojo, Hideaki, Baba, Atsuo, Sasaki, Satoshi

“…We recently reported the discovery of the novel pyrrolo[3,2-c]quinoline-4-one derivative 1 as a potent inhibitor of Hedgehog (Hh) pathway signaling. However,…”
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Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors by Ohashi, Tomohiro, Oguro, Yuya, Tanaka, Toshio, Shiokawa, Zenyu, Shibata, Sachio, Sato, Yoshihiko, Yamakawa, Hiroko, Hattori, Harumi, Yamamoto, Yukiko, Kondo, Shigeru, Miyamoto, Maki, Tojo, Hideaki, Baba, Atsuo, Sasaki, Satoshi

“…The Hedgehog (Hh) signaling pathway plays a significant role in the regulation of cell growth and differentiation during embryonic development. Since…”
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Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2‑a]pyrazine Scaffold as a Novel Proline Mimetic by Hashimoto, Kentaro, Saito, Bunnai, Miyamoto, Naoki, Oguro, Yuya, Tomita, Daisuke, Shiokawa, Zenyu, Asano, Moriteru, Kakei, Hiroyuki, Taya, Naohiro, Kawasaki, Masanori, Sumi, Hiroyuki, Yabuki, Masato, Iwai, Kenichi, Yoshida, Sei, Yoshimatsu, Mie, Aoyama, Kazunobu, Kosugi, Yohei, Kojima, Takashi, Morishita, Nao, Dougan, Douglas R, Snell, Gyorgy P, Imamura, Shinichi, Ishikawa, Tomoyasu

“…To develop novel inhibitor of apoptosis (IAP) proteins antagonists, we designed a bicyclic octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline…”
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Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists by Asano, Moriteru, Hashimoto, Kentaro, Saito, Bunnai, Shiokawa, Zenyu, Sumi, Hiroyuki, Yabuki, Masato, Yoshimatsu, Mie, Aoyama, Kazunobu, Hamada, Teruki, Morishita, Nao, Dougan, Douglas R., Mol, Clifford D., Yoshida, Sei, Ishikawa, Tomoyasu

“…We recently reported the discovery of octahydropyrrolo[1,2-a]pyrazine A as a lead compound for an inhibitor of apoptosis proteins (IAP) antagonist. To develop…”
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Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist by Yukawa, Tomoya, Nara, Yoshi, Kono, Mitsunori, Sato, Ayumu, Oda, Tsuneo, Takagi, Terufumi, Sato, Takayuki, Banno, Yoshihiro, Taya, Naohiro, Imada, Takashi, Shiokawa, Zenyu, Negoro, Nobuyuki, Kawamoto, Tetsuji, Koyama, Ryokichi, Uchiyama, Noriko, Skene, Robert, Hoffman, Isaac, Chen, Chien-Hung, Sang, BiChing, Snell, Gyorgy, Katsuyama, Ryosuke, Yamamoto, Satoshi, Shirai, Junya

“…Retinoic acid receptor-related orphan receptor γt (RORγt) agonists are expected to provide a novel class of immune-activating anticancer drugs via activation…”
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Gene Signature-Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNFα Treatment for Crohn's Disease by Gamo, Kanae, Okuzono, Yuumi, Yabuki, Masato, Ochi, Takashi, Sugimura, Kyoko, Sato, Yosuke, Sagara, Masaki, Hayashi, Hiroki, Ishimura, Yoshimasa, Nishimoto, Yutaka, Murakawa, Yusuke, Shiokawa, Zenyu, Gotoh, Masayuki, Miyazaki, Takahiro, Ebisuno, Yukihiko

“…Abstract Background Anti-tumor necrosis factor alpha (anti-TNFα) therapy has become the mainstay of therapy for Crohn's disease (CD). However, post-therapy,…”
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Discovery of a Novel Scaffold as an Indoleamine 2,3-Dioxygenase1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, LongamideB by Shiokawa, Zenyu, Kashiwabara, Emi, Yoshidome, Daisuke, Fukase, Koichi, Inuki, Shinsuke, Fujimoto, Yukari

“…Indoleamine 2,3-dioxygenase1 (IDO1) has emerged as a key target for cancer therapy, as IDO1 plays a critical role in the capacity of tumor cells to evade the…”
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Gene Signature-Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNF[alpha] Treatment for Crohn's Disease by Gamo, Kanae, Okuzono, Yuumi, Yabuki, Masato, Ochi, Takashi, Sugimura, Kyoko, Sato, Yosuke, Sagara, Masaki, Hayashi, Hiroki, Ishimura, Yoshimasa, Nishimoto, Yutaka, Murakawa, Yusuke, Shiokawa, Zenyu, Gotoh, Masayuki, Miyazaki, Takahiro, Ebisuno, Yukihiko

“…Background: Anti-tumor necrosis factor alpha (anti-TNF[alpha]) therapy has become the mainstay of therapy for Crohn's disease (CD). However, post-therapy, the…”
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Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells by Shiokawa, Zenyu, Hashimoto, Kentaro, Saito, Bunnai, Oguro, Yuya, Sumi, Hiroyuki, Yabuki, Masato, Yoshimatsu, Mie, Kosugi, Yohei, Debori, Yasuyuki, Morishita, Nao, Dougan, Douglas R., Snell, Gyorgy P., Yoshida, Sei, Ishikawa, Tomoyasu

“…We previously reported octahydropyrrolo[1,2-a]pyrazine derivative 2 (T-3256336) as a potent antagonist for inhibitors of apoptosis (IAP) proteins. Because…”
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Synthesis and evaluation of hedgehog signaling inhibitor with novel core system by Ohashi, Tomohiro, Tanaka, Yuta, Shiokawa, Zenyu, Banno, Hiroshi, Tanaka, Toshio, Shibata, Sachio, Satoh, Yoshihiko, Yamakawa, Hiroko, Yamamoto, Yukiko, Hattori, Harumi, Kondo, Shigeru, Miyamoto, Maki, Tojo, Hideaki, Baba, Atsuo, Sasaki, Satoshi

“…[Display omitted] As we previously reported, N-methylpyrrolo[3,2-c]pyridine derivatives 1 (TAK-441) was discovered as a clinical candidate of hedgehog (Hh)…”
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Synthesis of peptidoglycan fragments and evaluation of their biological activity by Inamura, Seiichi, Fujimoto, Yukari, Kawasaki, Akiko, Shiokawa, Zenyu, Woelk, Eva, Heine, Holger, Lindner, Buko, Inohara, Naohiro, Kusumoto, Shoichi, Fukase, Koichi

“…The peptidoglycan (PG) bacterial cell wall glycoconjugate has been well known as a strong immunopotentiator. Partial structures of PG were chemically…”
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Multimeric bivalent immunogens from recombinant tetanus toxin HC fragment, synthetic hexasaccharides, and a glycopeptide adjuvant by Bongat, Aileen F. G, Saksena, Rina, Adamo, Roberto, Fujimoto, Yukari, Shiokawa, Zenyu, Peterson, Dwight C, Fukase, Koichi, Vann, Willie F, Kováč, Pavol

“…Using recombinant tetanus toxin HC fragment (rTT-HC) as carrier, we prepared multimeric bivalent immunogens featuring the synthetic hexasaccharide fragment of…”
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Multimeric bivalent immunogens from recombinant tetanus toxin H sub(C) fragment, synthetic hexasaccharides, and a glycopeptide adjuvant by Bongat, Aileen FG, Saksena, Rina, Adamo, Roberto, Fujimoto, Yukari, Shiokawa, Zenyu, Peterson, Dwight C, Fukase, Koichi, Vann, Willie F, Kovac, Pavol

“…Using recombinant tetanus toxin H sub(C) fragment (rTT-H sub(C)) as carrier, we prepared multimeric bivalent immunogens featuring the synthetic hexasaccharide…”
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Chemical synthesis of peptidoglycan fragments for elucidation of the immunostimulating mechanism by Fujimoto, Yukari, Inamura, Seiichi, Kawasaki, Akiko, Shiokawa, Zenyu, Shimoyama, Atsushi, Hashimoto, Takashi, Kusumoto, Shoichi, Fukase, Koichi

“…Partial structures of peptidoglycan were chemically synthesized for elucidation of their precise biological activities. By using an efficient synthetic…”
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