Search Results - "Shintaro Ide"
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Sertoli cell ablation and replacement of the spermatogonial niche in mouse
Published in Nature communications (02-01-2020)“…Spermatogonia, which produce sperm throughout the male lifetime, are regulated inside a niche composed of Sertoli cells, and other testis cell types. Defects…”
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Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair
Published in eLife (19-07-2021)“…Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic form of regulated cell death that has been implicated in…”
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Updates on dyslipidemia in patients with diabetes
Published in Journal of diabetes investigation (01-09-2023)Get full text
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Yolk-sac-derived macrophages progressively expand in the mouse kidney with age
Published in eLife (17-04-2020)“…Renal macrophages represent a highly heterogeneous and specialized population of myeloid cells with mixed developmental origins from the yolk-sac and…”
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Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development
Published in Journal of the American Society of Nephrology (01-12-2018)“…The mammalian kidney develops through reciprocal inductive signals between the metanephric mesenchyme and ureteric bud. Transcription factor 21 (Tcf21) is…”
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Comparison of Visceral Fat Reduction by Ipragliflozin and Metformin in Elderly Type 2 Diabetes Patients: Sub-Analysis of a Randomized-Controlled Study
Published in Diabetes therapy (01-01-2021)“…Introduction To compare the effects of ipragliflozin, a sodium-glucose transporter 2 inhibitor, with those of metformin on visceral fat (as well as muscles and…”
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Low dose red yeast rice with monacolin K lowers LDL cholesterol and blood pressure in Japanese with mild dyslipidemia: A multicenter, randomized trial
Published in Asia Pacific Journal of Clinical Nutrition (01-09-2021)“…Background and Objectives: Red yeast rice contains monacolin K, an inhibitor of cholesterol synthesis, and gamma-aminobutyric acid, a neurotransmitter. The…”
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Effects of ipragliflozin versus metformin in combination with sitagliptin on bone and muscle in Japanese patients with type 2 diabetes mellitus: Subanalysis of a prospective, randomized, controlled study (PRIME‐V study)
Published in Journal of diabetes investigation (01-02-2021)“…Aims/Introduction Recent randomized clinical trials have suggested that sodium–glucose cotransporter 2 inhibitors might reduce cardiovascular events and heart…”
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Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration
Published in JCI insight (09-08-2021)“…The transcription factor Twist1 regulates several processes that could impact kidney disease progression, including epithelial cell differentiation and…”
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Combination of cilostazol and probucol protected podocytes from lipopolysaccharide-induced injury by both anti-inflammatory and anti-oxidative mechanisms
Published in Journal of nephrology (01-08-2017)“…Podocytes are essential for maintaining kidney glomerular functions. Injuries to podocyte are closely related to the pathological process of proteinuria…”
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Hypoalbuminemia on admission in diabetic patients correlates with severity of illness in COVID-19: A retrospective clinical study and literature review
Published in Endocrine and metabolic science (01-09-2024)“…To elucidate factors associated with severe disease in patients with coronavirus disease 2019 (COVID-19) pneumonia complicated with diabetes mellitus. Among…”
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A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation
Published in Scientific reports (16-05-2016)“…Kidney diseases including diabetic nephropathy have become huge medical problems, although its precise mechanisms are still far from understood. In order to…”
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Case of Werner syndrome complicated by adrenal insufficiency due to hypothalamic dysfunction
Published in Geriatrics & gerontology international (01-02-2017)Get full text
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A macrophage-endothelial immunoregulatory axis ameliorates septic acute kidney injury
Published in Kidney international (01-03-2023)“…The most common cause of acute kidney injury (AKI) in critically ill patients is sepsis. Kidney macrophages consist of both F4/80 and CD11b cells. The role of…”
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Role of Cellular Senescence and Epigenetic Drift in Interstitial Fibrosis of Diabetic Kidney Disease: TH-PO227
Published in Journal of the American Society of Nephrology (01-11-2022)Get full text
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Type 1 Angiotensin Receptors on CD11c-Expressing Cells Protect Against Hypertension by Regulating Dendritic Cell–Mediated T Cell Activation
Published in Hypertension (Dallas, Tex. 1979) (01-06-2022)“…Type 1 angiotensin (AT ) receptors are expressed on immune cells, and we previously found that bone marrow-derived AT receptors protect against Ang…”
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Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair
Published in Cell reports (Cambridge) (08-11-2022)“…In both humans and mice, repair of acute kidney injury is worse in males than in females. Here, we provide evidence that this sexual dimorphism results from…”
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