Search Results - "Shinozuka, Kazumasa"

Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis by Nakamura, Kazuki, Shinozuka, Kazumasa, Yoshikawa, Noriko

“…Cordyceps sinensis, a fungus that parasitizes on the larva of Lepidoptera, has been used as a valued traditional Chinese medicine. We investigated the effects…”
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Acanthopanax senticosus Root Extract Exerts Dual Action on Mouse Ileal Smooth Muscle Function, Leading to Modulation of Gastrointestinal Motility by Miyauchi-Wakuda, Shino, Kagota, Satomi, Maruyama-Fumoto, Kana, Shiokawa, Yayoi, Yamada, Shizuo, Shinozuka, Kazumasa

“…Diarrhea is often caused by changes in lifestyle, stress, or side effects of drugs. Acanthopanax senticosus root extract (ASRE) has long been used as a…”
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Muscarinic receptor binding activity in rat tissues by vibegron and prediction of its receptor occupancy levels in the human bladder by Yamada, Shizuo, Chimoto, Junko, Shiho, Mizuki, Okura, Takashi, Morikawa, Kana, Kagota, Satomi, Shinozuka, Kazumasa

“…Objectives To examine the effects of vibegron, a selective β3‐adrenoceptor agonist, used to treat overactive bladder, on muscarinic receptors in the rat…”
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Effects of Anticholinergic Drugs Used for the Therapy of Overactive Bladder on P-Glycoprotein Activity by Wakuda, Hirokazu, Okura, Takashi, Maruyama-Fumoto, Kana, Kagota, Satomi, Ito, Yoshihiko, Miyauchi-Wakuda, Shino, Otani, Naoyuki, Uemura, Naoto, Yamada, Shizuo, Shinozuka, Kazumasa

“…We evaluated the effects of anticholinergic drugs principally used for the therapy of overactive bladder (OAB) on the activity of P-glycoprotein, an efflux…”
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Development of a pharmacological evidence‐based anticholinergic burden scale for medications commonly used in older adults by Yamada, Shizuo, Mochizuki, Masae, Chimoto, Junko, Futokoro, Risa, Kagota, Satomi, Shinozuka, Kazumasa

“…Aim The present study aimed to develop a pharmacological evidence‐based anticholinergic burden scale (ABS) through a direct assessment of muscarinic…”
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Direct in vitro and in vivo demonstration of muscarinic receptor binding by the novel radioligand, [3H]5-hydroxymethyltolterodine, in the bladder and other tissues of rats by Yamada, Shizuo, Kuraoka, Shiori, Ito, Yoshihiko, Kagota, Satomi, Shinozuka, Kazumasa, Onoue, Satomi

“…In vitro and in vivo binding sites of [3H]-labeled 5-hydroxymethyltolterodine (5-HMT), a new radioligand for labeling muscarinic receptors in rat tissues were…”
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trans-2-Pentenal, an Active Compound in Cigarette Smoke, Identified via Its Ability to Form Adducts with Glutathione by Hatai, Mayuko, Horiyama, Shizuyo, Yoshikawa, Noriko, Kinoshita, Eriko, Kagota, Satomi, Shinozuka, Kazumasa, Nakamura, Kazuki

“…α,β-Unsaturated carbonyl compounds readily form adducts with SH or NH2 residues, which are nucleophilic agents, by Michael addition. Glutathione (GSH) is a…”
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Acanthopanax senticosus Induces Vasorelaxation via Endothelial Nitric Oxide-Dependent and -Independent Pathways by Shiokawa, Yayoi, Miyauchi-Wakuda, Shino, Kagota, Satomi, Maruyama-Fumoto, Kana, Yamada, Shizuo, Shinozuka, Kazumasa

“…Although root extract (ASRE), a functional food used in Japan, improves peripheral blood circulation and exerts vasorelaxant effects in rats under healthy…”
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Effect of Royal Jelly on Mouse Isolated Ileum and Gastrointestinal Motility by Miyauchi-Wakuda, Shino, Kagota, Satomi, Maruyama-Fumoto, Kana, Wakuda, Hirokazu, Yamada, Shizuo, Shinozuka, Kazumasa

“…Royal jelly (RJ) is widely used as a cosmetic or dietary supplement to relieve various health disorders, such as dry skin, fatigue, and menopause. RJ has been…”
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Perivascular Adipose Tissue-Enhanced Vasodilation in Metabolic Syndrome Rats by Apelin and N -Acetyl⁻l-Cysteine-Sensitive Factor(s) by Kagota, Satomi, Maruyama-Fumoto, Kana, Iwata, Saki, Shimari, Miho, Koyanagi, Shiori, Shiokawa, Yayoi, McGuire, John J, Shinozuka, Kazumasa

“…Perivascular adipose tissue (PVAT) can regulate vascular tone. In mesenteric arteries of SHRSP.Z- /IzmDmcr rats (SHRSP.ZF) with metabolic syndrome, vascular…”
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A maternal high salt diet disturbs cardiac and vascular function of offspring by Maruyama, Kana, Kagota, Satomi, Van Vliet, Bruce N., Wakuda, Hirokazu, Shinozuka, Kazumasa

“…High salt intake is an environmental factor that promotes increased blood pressure. We previously demonstrated that high salt diet causes aggravation of…”
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Modulation of Vasomotor Function by Perivascular Adipose Tissue of Renal Artery Depends on Severity of Arterial Dysfunction to Nitric Oxide and Severity of Metabolic Parameters by Kagota, Satomi, Futokoro, Risa, McGuire, John J., Maruyama-Fumoto, Kana, Shinozuka, Kazumasa

“…Perivascular adipose tissue (PVAT) enhances vascular relaxation of mesenteric arteries in SHRSP.Z-Leprfa/IzmDmcr rats (SPZF), a metabolic syndrome model. We…”
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Effects of Dietary Ingredients on Function and Expression of P-Glycoprotein in Human Intestinal Epithelial Cells by Okura, Takashi, Ibe, Michiko, Umegaki, Keizo, Shinozuka, Kazumasa, Yamada, Shizuo

“…The present study was conducted to investigate the functional and transcriptional modulation of P-glycoprotein (MDR-1) by several dietary ingredients…”
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Characterization of muscarinic receptor binding by the novel radioligand, [3H]imidafenacin, in the bladder and other tissues of rats by Kuraoka, Shiori, Ito, Yoshihiko, Wakuda, Hirokazu, Shinozuka, Kazumasa, Onoue, Satomi, Yamada, Shizuo

“…The present study aimed to directly characterize specific binding sites of tritium ([3H])-labeled imidafenacin, a new radioligand for labeling muscarinic…”
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Antitumor Effect of Cordycepin (3′-Deoxyadenosine) on Mouse Melanoma and Lung Carcinoma Cells Involves Adenosine A3 Receptor Stimulation by NAKAMURA, Kazuki, YOSHIKAWA, Noriko, YAMAGUCHI, Yu, KAGOTA, Satomi, SHINOZUKA, Kazumasa, KUNITOMO, Masaru

“…An attempt was made to elucidate the molecular target for the antitumor effects of cordycepin (3′-deoxyadenosine) using non-selective and selective adenosine…”
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Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice by Taki, Yuko, Yokotani, Kaori, Yamada, Shizuo, Shinozuka, Kazumasa, Kubota, Yoko, Watanabe, Yasuo, Umegaki, Keizo

“…Ginkgo biloba extract (GBE) is a popular herbal ingredient used worldwide, but it is reported to induce bleeding as a serious adverse event. In this study we…”
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St. John’s Wort Promotes Adipocyte Differentiation and Modulates NF-κB Activation in 3T3-L1 Cells by Hatano, Tomoko, Sameshima, Yuka, Kawabata, Mami, Yamada, Shizuo, Shinozuka, Kazumasa, Nakabayashi, Toshikatsu, Mizuno, Hideya

“…St. John’s wort (SJW), or Hypericum perforatum, is a perennial herb that has been used in the treatment of depression in several countries. Though its…”
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Is Hyperuricemia a Risk Factor for Arteriosclerosis? Uric Acid and Arteriosclerosis in Apolipoprotein E-Deficient Mice by Wakuda, Hirokazu, Uchida, Shinya, Ikeda, Masahiko, Tabuchi, Masaki, Akahoshi, Yasumitsu, Shinozuka, Kazumasa, Yamada, Shizuo

“…Although hyperlipidemia, high blood pressure, and diabetes increase the risk of arteriosclerosis, it is not clear whether hyperuricemia increases the risk of…”
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Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats by Kubota, Yoko, Umegaki, Keizo, Kagota, Satomi, Tanaka, Naoko, Nakamura, Kazuki, Kunitomo, Masaru, Shinozuka, Kazumasa

“…Conventional noninvasive blood pressure in conscious rats or mice are typically measured using the tail-cuff method after heating the animal. The goal of this…”
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Age-related changes to vascular protease-activated receptor 2 in metabolic syndrome: a relationship between oxidative stress, receptor expression, and endothelium-dependent vasodilation by Maruyama, Kana, Kagota, Satomi, McGuire, John J, Wakuda, Hirokazu, Yoshikawa, Noriko, Nakamura, Kazuki, Shinozuka, Kazumasa

“…Protease-activated receptor 2 (PAR2) is expressed in vascular endothelium. Nitric oxide (NO) - cyclic GMP-mediated vasodilation in response to…”
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