Search Results - "Shinkel, T. A."

Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons by COWAN, P. J, AMINIAN, A, NOTTLE, M. B, PEARSE, M. J, SALVARIS, E, SHINKEL, T. A, STAINSBY, G. V, STEWART, A. B, D'APICE, A. J. F, BARLOW, H, BROWN, A. A, CHEN, C.-G, FISICARO, N, FRANCIS, D. M. A, GOODMAN, D. J, WENRUO HAN, KUREK, M

“…The genetic modification of pigs is a powerful strategy that may ultimately enable successful xenotransplantation of porcine organs into humans. Transgenic…”
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The α-1,3-galactosyltransferase knockout mouse : implications for xenotransplantation by TEARLE, R. G, TANGE, M. J, BECKER, C, PEURA, A. M, WIGLEY, P. L, CRAWFORD, R. J, ROBINS, A. J, PEARSE, M. J, D'APICE, A. J. F, ZANNETTINO, Z. L, KATERELOS, M, SHINKEL, T. A, VAN DENDEREN, B. J. W, LONIE, A. J, LYONS, I, NOTTLE, M. B, COX, T

“…Organ xenografts in discordant combinations such as pig-to-man undergo hyperacute rejection due to the presence of naturally occurring human anti-pig…”
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Protective Effects of Recombinant Human Antithrombin III in Pig‐to‐Primate Renal Xenotransplantation by Cowan, P. J., Aminian, A., Barlow, H., Brown, A. A., Dwyer, K., Filshie, R. J. A., Fisicaro, N., Francis, D. M. A., Gock, H., Goodman, D. J., Katsoulis, J., Robson, S. C., Salvaris, E., Shinkel, T. A., Stewart, A. B., D'Apice, A. J. F.

“…Delayed rejection of pig kidney xenografts by primates is associated with vascular injury that may be accompanied by a form of consumptive coagulopathy in…”
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Immunocytochemical localization of angiotensinogen in the fetal and neonatal rat brain by Mungall, B.A., Shinkel, T.A., Sernia, C.

“…The aim of this study was to define the temporal appearance and regional distribution of angiotensinogen in the fetal and neonatal rat brain. This was done by…”
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Targeting gene expression to endothelial cells in transgenic mice using the human intercellular adhesion molecule 2 promoter by COWAN, P. J, SHINKEL, T. A, WITORT, E. J, BARLOW, H, PEARSE, M. J, D'APICE, A. J. F

“…Genetic engineering of donor animals in xenotransplantation research has been directed largely toward obtaining expression of various immunoregulatory…”
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High-level endothelial expression of human CD59 prolongs heart function in an ex vivo model of xenograft rejection by COWAN, P. J, SOMERVILLE, C. A, SHINKEL, T. A, KATERELOS, M, AMINIAN, A, ROMANELLA, M, TANGE, M. J, PEARSE, M. J, D'APICE, A. J. F

“…Hyperacute rejection of discordant xenografts is dependent on activation of the complement system of the recipient. Transgenic expression of recipient…”
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Expression and functional analysis of glycosyl-phosphatidyl inositol-linked CD46 in transgenic mice by SHINKEL, T. A, COWAN, P. J, BARLOW, H, AMINIAN, A, ROMANELLA, M, LUBLIN, D. M, PEARSE, M. J, D'APICE, A. J. F

“…Complement activation plays a pivotal role in hyperacute xenograft rejection. In humans, activation of complement is regulated by a number of cell surface…”
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Angiotensinogen is secreted by pure rat neuronal cell cultures by Thomas, W G, Greenland, K J, Shinkel, T A, Sernia, C

“…Previous studies are divided between those which support a neuroglial (astrocyte) source for brain angiotensinogen and those which indicate that both…”
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Expression of functional decay-accelerating factor (CD55) in transgenic mice protects against human complement-mediated attack by VAN DENDEREN, B. J. W, PEARSE, M. J, D'APICE, A. J. F, KATERELOS, M, NOTTLE, M. B, DU, Z.-T, AMINIAN, A, ADAM, W. R, SHENOY-SCARIA, A, LUBLIN, D. M, SHINKEL, T. A

“…Transgenic mice expressing human CD55 were generated by microinjection of a CD55-minigene under the control of the mouse H2K(b) (MHC class I) promoter…”
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Anti-Gal antibody-mediated allograft rejection in α1,3-galactosyltransferase gene knockout mice: A model of delayed xenograft rejection by PEARSE, M. J, WITORT, E, MOTTRAM, P, WENRUO HAN, MURRAY-SEGAL, L, ROMANELLA, M, SALVARIS, E, SHINKEL, T. A, GOODMAN, D. J, D'APICE, A. J

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Decay-accelerating factor transgenic mouse hearts are protected from human complement-mediated attack by van Denderen, B J, Pearse, M J, Aminian, A, Adam, W, Shinkel, T A, d'Apice, A J

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Changes in cell surface glycosylation in alpha 1,3-galactosyltransferase knockout and alpha 1,2-fucosyltransferase transgenic mice by Shinkel, T A, Chen, Chao-Guang, Salvaris, E, Henion, T R, Barlow, H, Galili, U, Pearse, MJ, D'Apice, AJF

“…Inactivation of the alpha 1,3-galactosyltransferase (GalT) gene by homologous recombination (knockout [KO] mice) and competition for the enzyme's…”
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The Human ICAM-2 Promoter is Endothelial Cell-specific in Vitro and in Vivo and Contains Critical Sp1 and GATA Binding Sites by Cowan, P J, Tsang, D, Pedic, C M, Abbott, L R, Shinkel, T A, d'Apice, A J, Pearse, M J

“…The expression of intercellular adhesion molecule 2 (ICAM-2) in adult tissues is restricted to vascular endothelial cells and megakaryocytes. We have…”
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Anti-gal antibody-mediated allograft rejection in alpha 1,3-galactosyltransferase gene knockout mice: A model of delayed xenograft rejection by Pearse, MJ, Witort, E, Mottram, P, Han, W, Murray-Segal, L, Romanella, M, Salvaris, E, Shinkel, T A, Goodman, D J, d'Apice, A J

“…The key role of anti-galactose alpha 1,3-galactose (anti- alpha Gal) xenoantibodies in initiating hyperacute xenograft rejection has been clearly demonstrated…”
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Knock out of alpha 1,3-galactosyltransferase or expression of alpha 1,2-fucosyltransferase further protects CD55- and CD59-expressing mouse hearts in an ex vivo model of xenograft rejection by Cowan, P J, Chen, Chao-Guang, Shinkel, T A, Fisicaro, N, Salvaris, E, Aminian, A, Romanella, M, Pearse, MJ, D'Apice, AJF

“…Organs from transgenic animals with high-level endothelial expression of the human complement regulatory factors CD55 and CD59 are significantly protected from…”
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Anti-xenograft immune responses in alpha 1,3-galactosyltransferase knock-out mice by Pearse, M J, Cowan, P J, Shinkel, T A, Chen, C G, d'Apice, A J

“…Although originally generated to test the effect of eliminating the alpha-Gal epitope on HAR, it is becoming increasingly clear that GalT KO mice offer a…”
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High-level co-expression of complement regulators on vascular endothelium in transgenic mice: CD55 and CD59 provide greater protection from human complement-mediated injury than CD59 alone by Cowan, Peter J., Shinkel, Trixie A., Aminian, Atousa, Romanella, Margarita, Wigley, Peter L, Lonie, Andrew J., Nottle, Mark B., Pearse, Martin J., D'Apice, Anthony J.F.

“…: High‐level endothelial expression of the human complement regulatory factor CD59 has been shown to protect transgenic mouse hearts from human…”
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Two genetic approaches to the galactose alpha 1,3 galactose xenoantigen by d'Apice, A J, Tange, M J, Chen, G C, Cowan, P J, Shinkel, T A, Pearse, M J

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Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets From Oxidative Injury and Improves Islet Graft Function by MYSORE, Tharun B, SHINKEL, Trixie A, CHANDRA, Abhilash P, O'CONNELL, Philip J, D'APICE, Anthony J. F, COWAN, Peter J, COLLINS, James, SALVARIS, Evelyn J, FISICARO, Nella, MURRAY-SEGAL, Lisa J, JOHNSON, Lucinda E. A, LEPORE, Diana A, WALTERS, Stacey N, STOKES, Rebecca

“…Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets From Oxidative Injury and Improves Islet Graft…”
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Changes in cell surface glycosylation in α1,3-galactosyltransferase knockout and α1,2-fucosyltransferase transgenic mice by SHINKEL, T. A, CHEN, C.-G, SALVARIS, E, HENION, T. R, BARLOW, H, GALILI, U, PEARSE, M. J, D'APICE, A. J. F

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