Search Results - "Shinkai, Sachihiko"

PHASE I CLINICAL STUDIES ON A NOVEL ORAL CEPHEM ANTIBIOTIC, ME 1207 by Shimada, Kaoru, Matsumoto, Takashi, Komiya, Izumi, Shinkai, Sachihiko

“…ME 1207, a novel oral cephem antibiotic, is a prodrug of ME1206 which has a potent activity againsta broad spectrum of bacteria.Our preclinical animal studies…”
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TISSUE DISTRIBUTION OF ME 1207 IN DOGS by Izumi, Masaaki, Inaba, Tsuneyoshi, Shinkai, Sachihiko, Nakayoshi, Takemi

“…A new oral cepharosporin antibiotic, ME 1207, was given in doses of 100mg/kg to beagle dogs inorder to study its distribution to various tissues. The following…”
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ASSAY METHOD OF HBK IN BIOLOGICAL FLUIDS: I. MICROBIOLOGIGAL ASSAY METHOD by SHINKAI, SACHIHIKO, ISHIWATARI, NOBUYOSHI, FUJITA, MASATAKA

“…Microbiological assay methods of HBK in biological fluids were studied. The assay methods using Bacillus subtilis ATCC 6633 as a test organism, Mycin assay…”
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ASSAY METHOD OF ME 1207, A NOVEL ORAL CEPHEM ANTIBIOTIC, IN BIOLOGICAL BODY FLUIDS: I. MICROBIOLOGICAL ASSAY METHOD by Ishiwatari, Nobuyoshi, Oishi, Shigeki, Nakayama, Etsuko, Shinkai, Sachihiko

“…Microbiological assay methods were examined for the quantitative determination of ME 1206, the active metabolite of ME 1207, in human serum or urine. ME 1207…”
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PHARMACOKINETICS OF HBK IN HEALTHY ADULT VOLUNTEERS by YAMASAKU, FUSANOSUKE, SUZUKI, YASUTOSHI, SHINKAI, SACHIHIKO, SHOMURA, TOMOKO, KOMIYA, IZUMI

“…Two groups of healthy adult subjects consisting of 4 subjects each were treated with HBK by i. m. route or by i. v. infusion route using rate constant infusion…”
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THE STUDIES ON ASSAY METHOD OF MT-141LEVELS IN BIOLOGICAL FLUIDS by SHINKAI, SACHIHIKO, OGAWA, TERUMI, FUJITA, MASATAKA, KOMIYA, IZUMI, MURATA, SHINJIRO

“…Quantitative determination methods of MT-141 in biological fluids are described. Among various microbiological methods tested, a cup-plate method using Vibrio…”
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A novel method to predict the elimination half-lives and the renal excretion mechanisms of cephalosporins by Komiya, I, Nishio, M, Murata, S, Chiba, F, Sakurai, T, Shinkai, S, Fujita, M

“…A novel method was proposed to predict the elimination half-lives of cephalosporins from plasma protein binding (unbound fraction, f) and fraction of the dose…”
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PHARMACOKINETICS OF MT-141: SERUM LEVELS AND URINARY EXCRETIONS by TOMONO, NORIKO, CHIBA, FUMIKO, SAKURAI, TAKASHI, NAKAYOSHI, TAKEMI, SHINKAI, SACHIHIKO, FUJITA, MASATAKA, KOMIYA, IZUMI

“…MT-141 was intravenously administered to rabbits and dogs at a dose of 20 or 40mg/kg in order to compare its pharmacokinetics with that of cefmetazole (CMZ)…”
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PHARMACOKINETICS OF MT-141: II. DISTRIBUTION IN TISSUES by TOMONO, NORIKO, CHIBA, FUMIKO, SAKURAI, TAKASHI, NAKAYOSHI, TAKEMI, SHINKAI, SACHIHIKO, FUJITA, MASATAKA

“…MT-141 was intravenously infused to rabbits at a dose of 40mg/kg in order to compare its distribution to various tissues with that of cefmetazole (CMZ), and…”
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RENAL EXCRETION MECHANISM OF MT-141 IN DOGS AND RATS by KOMIYA, IZUMI, YONEYAMA, SHOJI, NAKAYOSHI, TAKEMI, SHINKAI, SACHIHIKO, FUJITA, MASATAKA, NISHIO, MOTOHIRO

“…Renal excretion mechanism of MT-141, a novel cephamycin antibiotic, was studied in dogs and rats. The serum level and the cumulative urinary excretion of…”
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Pharmacokinetics of arbekacin in dogs. II. The distribution of arbekacin in tissues by Tomono, N, Nakayoshi, T, Shinkai, S, Fujita, M

“…A new aminoglycoside antibiotic, arbekacin (HBK) was intramuscularly and intravenously administered to Beagle dogs at a dose of 10 mg/kg to study its…”
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Pharmacokinetics of arbekacin in dogs. I. Serum concentration and urinary excretion by Tomono, N, Sannomiya, F, Nakayoshi, T, Shinkai, S, Fujita, M

“…A new aminoglycoside antibiotic, arbekacin (HBK) was intramuscularly and intravenously administered to dogs in order to study its pharmacokinetics in…”
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Tissue distribution of cefminox in beagle dogs by Chiba, F, Sakurai, T, Nakayoshi, T, Shinkai, S, Fujita, M, Komiya, I

“…A new cephamycin antibiotic, cefminox (MT-141, CMNX), was intravenously infused into Beagle dogs at a dose of 40 mg/kg in order to study it's distribution to…”
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A rapid enzyme immunoassay for measurement of HBK in blood by Ueda, T, Shimada, N, Yokoshima, T, Shomura, T, Komiya, I, Shinkai, S

“…An enzyme immunoassay has been developed for the measurement of HBK (4-amino-2-hydroxybutylyldibekacin) a new semisynthetic aminoglycoside antibiotic. Antisera…”
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