Search Results - "Shinguh, Yasuhiko"

Release of neutrophil elastase and its role in tissue injury in acute inflammation: effect of the elastase inhibitor, FR134043 by Fujie, Keiko, Shinguh, Yasuhiko, Inamura, Noriaki, Yasumitsu, Ritsuko, Okamoto, Masanori, Okuhara, Masakuni

“…Neutrophil elastase degrades extracellular matrix components and is involved in tissue destruction in several inflammatory states. We examined the inhibition…”
Get full text

FR901277, a novel inhibitor of human leukocyte elastase from Streptomyces resistomycificus. Producing organism, fermentation, isolation, physico-chemical and biological properties by Fujie, K, Shinguh, Y, Hatanaka, H, Shigematsu, N, Murai, H, Fujita, T, Yamashita, M, Okamoto, M, Okuhara, M

“…A novel human leukocyte elastase inhibitor, FR901277 was discovered in the fermentation broth of Streptomyces resistomycificus No. 7622. FR901277 has a…”
Get more information

Pharmacological evaluation of FK706, a novel and potent elastase inhibitor by Yamazaki, Akiko, Shinguh, Yasuhiko, Inamura, Noriaki, Nakahara, Kunio, Shirnomura, Kyoujchi, Ono, Takaharu

“…We found a novel and potent elastase inhibitor, FK706, sodium…”
Get full text

High Throughput Screening in the Japanese Pharmaceutical Industry by Yasuhiko Shinguh

“…During the past 5 years, Japanese pharmaceutical companies have introduced high throughput screening (HTS) into their laboratories as a major tool for the…”
Get full text

Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor by Shinguh, Yasuhiko, Imai, Keisuke, Yamazaki, Akiko, Inamura, Noriaki, Shima, Ichiro, Wakabayashi, Akiko, Higashi, Yasuyuki, Ono, Takaharu

“…FK706, sodium 2-[4-[[( S)-1-[[( S)-2-[[( RS)-3, 3, 3-trifluoro-1-isopropyl-2-oxopropyl]aminocarbonyl]pyrrolidin-1-yl]carbonyl]-2-methylpropyl] aminocarbonyl]…”
Get full text

Biochemical and pharmacological characterization of FR134043, a novel elastase inhibitor by Shinguh, Yasuhiko, Yamazaki, Akiko, Inamura, Noriaki, Fujie, Keiko, Okamoto, Masanori, Nakahara, Kunio, Notsu, Yoshitada, Okuhara, Masakuni, Ono, Takaharu

“…FR134043, disodium( Z,1 S,15 S,18 S,24 S,27 R,29 S,34 S,37…”
Get full text

FR901451, a novel inhibitor of human leukocyte elastase from Flexibacter sp. II. Pharmacological effect of FR901451 by Fujita, T, Shinguh, Y, Yamazaki, A, Nakahara, K, Okamoto, M, Okuhara, M

“…Intratracheal (i.t.) or intravenous (i.v.) administration of FR901451, a potent inhibitor of human leukocyte elastase (HLE) prevented HLE-induced lung…”
Get more information

Erratum by Yamazaki, Akiko, Shinguh, Yasuhiko, Inamura, Noriaki

Get full text

O-222 - Pharmacological properties of a novel and potent elastase inhibitor, FR134043 by Shinguh, Yasuhiko, Yamazaki, Akiko, Inamura, Noriaki, Nakahara, Kunio, Notsu, Yoshitada, Okamoto, Masanori, Okuhara, Masakuni, Henmi, Keiji, Tanaka, Hirokazu, Ono, Takaharu

Get full text

Pharmacological properties of a novel and potent elastase inhibitor, FR134043 by Shinguh, Yasuhiko, Yamazaki, Akiko, Inamura, Noriaki, Nakahara, Kunio, Notsu, Yoshitada, Okamoto, Masanori, Okuhara, Masakuni, Henmi, Keiji, Tanaka, Hirokazu, Ono, Takaharu

Get full text