Search Results - "Shine, Emilee E"

Structure elucidation of colibactin and its DNA cross-links by Xue, Mengzhao, Kim, Chung Sub, Healy, Alan R, Wernke, Kevin M, Wang, Zhixun, Frischling, Madeline C, Shine, Emilee E, Wang, Weiwei, Herzon, Seth B, Crawford, Jason M

“…Colibactin is a complex secondary metabolite produced by some genotoxic gut strains. The presence of colibactin-producing bacteria correlates with the…”
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Integration-Dependent Bacteriophage Immunity Provides Insights into the Evolution of Genetic Switches by Broussard, Gregory W., Oldfield, Lauren M., Villanueva, Valerie M., Lunt, Bryce L., Shine, Emilee E., Hatfull, Graham F.

“…Genetic switches are critical components of developmental circuits. Because temperate bacteriophages are vastly abundant and greatly diverse, they are rich…”
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Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis by Trautman, Eric P, Healy, Alan R, Shine, Emilee E, Herzon, Seth B, Crawford, Jason M

“…Modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) comprise giant multidomain enzymes responsible for the “assembly line”…”
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Characterization of Autoinducer‑3 Structure and Biosynthesis in E. coli by Kim, Chung Sub, Gatsios, Alexandra, Cuesta, Santiago, Lam, Yick Chong, Wei, Zheng, Chen, Haiwei, Russell, Regan M, Shine, Emilee E, Wang, Rurun, Wyche, Thomas P, Piizzi, Grazia, Flavell, Richard A, Palm, Noah W, Sperandio, Vanessa, Crawford, Jason M

“…Escherichia coli is a common inhabitant of the human microbiota and a beacon model organism in biology. However, an understanding of its signaling systems that…”
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Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria by Shine, Emilee E, Xue, Mengzhao, Patel, Jaymin R, Healy, Alan R, Surovtseva, Yulia V, Herzon, Seth B, Crawford, Jason M

“…Colibactins are genotoxic secondary metabolites produced in select Enterobacteriaceae, which induce downstream DNA double-strand breaks (DSBs) in human cell…”
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Molecules from the Microbiome by Shine, Emilee E, Crawford, Jason M

“…The human microbiome encodes a second genome that dwarfs the genetic capacity of the host. Microbiota-derived small molecules can directly target human cells…”
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Escherichia coli-Derived γ‑Lactams and Structurally Related Metabolites Are Produced at the Intersection of Colibactin and Fatty Acid Biosynthesis by Kim, Chung Sub, Turocy, Tayah, Moon, Gyuri, Shine, Emilee E, Crawford, Jason M

“…Colibactin is a genotoxic hybrid polyketide-nonribosomal peptide that drives colorectal cancer initiation. While clinical data suggest colibactin genotoxicity…”
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ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance by Tripathi, Prabhanshu, Shine, Emilee E, Healy, Alan R, Kim, Chung Sub, Herzon, Seth B, Bruner, Steven D, Crawford, Jason M

“…Certain commensal Escherichia coli contain the clb biosynthetic gene cluster that codes for small molecule prodrugs known as precolibactins. Precolibactins are…”
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