Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations

Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations

The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved t...

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Bibliographic Details
Published in:Pharmaceutics Vol. 14; no. 12; p. 2632
Main Authors: Pardeshi, Sagar R, Kole, Eknath B, Kapare, Harshad S, Chandankar, Sachin M, Shinde, Prashant J, Boisa, Ganesh S, Salgaonkar, Sanjana S, Giram, Prabhanjan S, More, Mahesh P, Kolimi, Praveen, Nyavanandi, Dinesh, Dyawanapelly, Sathish, Junnuthula, Vijayabhaskarreddy
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 28-11-2022
MDPI
Subjects:
Aerosols
Bioavailability
Biological products
Chemical properties
Dielectric films
Drug dosages
Drug therapy
dry fine powder
Freeze-drying
Humidity
inhalation
Inhaled medication
Lung diseases
Methods
novel drug delivery
Pharmaceuticals
poorly soluble drug
Powders (Pharmacy)
Production processes
pulmonary
Review
Solvents
thin film freezing
Thin films
Vaccines
India
thin film freezing
inhalation
dry fine powder
novel drug delivery
pulmonary
poorly soluble drug
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Summary:The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved the way for commercialization. Thin film freezing (TFF) is a new emerging freeze-drying technique available for various treatment modalities in drug delivery. TFF has now been used for the commercialization of pharmaceuticals, food, and biopharmaceutical products. The present review highlights the fundamentals of TFF along with modulated techniques used for drying pharmaceuticals and biopharmaceuticals. Furthermore, we have covered various therapeutic applications of TFF technology in the development of nanoformulations, dry powder for inhalations and vaccines. TFF holds promise in delivering therapeutics for lung diseases such as fungal infection, bacterial infection, lung dysfunction, and pneumonia.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14122632