Search Results - "Shin-ichi Oka"

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy by Tong, Mingming, Saito, Toshiro, Zhai, Peiyong, Oka, Shin-ichi, Mizushima, Wataru, Nakamura, Michinari, Ikeda, Shohei, Shirakabe, Akihiro, Sadoshima, Junichi

“…RATIONALE:Diabetic patients develop cardiomyopathy characterized by hypertrophy, diastolic dysfunction, and intracellular lipid accumulation, termed…”
Get full text

Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy by Tong, Mingming, Saito, Toshiro, Zhai, Peiyong, Oka, Shin-ichi, Mizushima, Wataru, Nakamura, Michinari, Ikeda, Shohei, Shirakabe, Akihiro, Sadoshima, Junichi

“…Obesity-associated cardiomyopathy characterized by hypertrophy and mitochondrial dysfunction. Mitochondrial quality control mechanisms, including mitophagy,…”
Get full text

An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia by Saito, Toshiro, Nah, Jihoon, Oka, Shin-Ichi, Mukai, Risa, Monden, Yoshiya, Maejima, Yasuhiro, Ikeda, Yoshiyuki, Sciarretta, Sebastiano, Liu, Tong, Li, Hong, Baljinnyam, Erdene, Fraidenraich, Diego, Fritzky, Luke, Zhai, Peiyong, Ichinose, Shizuko, Isobe, Mitsuaki, Hsu, Chiao-Po, Kundu, Mondira, Sadoshima, Junichi

“…Energy stress, such as ischemia, induces mitochondrial damage and death in the heart. Degradation of damaged mitochondria by mitophagy is essential for the…”
Get full text

YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload by Kashihara, Toshihide, Mukai, Risa, Oka, Shin-Ichi, Zhai, Peiyong, Nakada, Yasuki, Yang, Zhi, Mizushima, Wataru, Nakahara, Tsutomu, Warren, Junco S, Abdellatif, Maha, Sadoshima, Junichi

“…The heart utilizes multiple adaptive mechanisms to maintain pump function. Compensatory cardiac hypertrophy reduces wall stress and oxygen consumption, thereby…”
Get full text

KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy by Kyriazis, Ioannis D., Hoffman, Matthew, Gaignebet, Lea, Lucchese, Anna Maria, Markopoulou, Eftychia, Palioura, Dimitra, Wang, Chao, Bannister, Thomas D., Christofidou-Solomidou, Melpo, Oka, Shin-ichi, Sadoshima, Junichi, Koch, Walter J., Goldberg, Ira J., Yang, Vincent W., Bialkowska, Agnieszka B., Kararigas, Georgios, Drosatos, Konstantinos

“…Diabetic cardiomyopathy (DbCM) is a major complication in type-1 diabetes, accompanied by altered cardiac energetics, impaired mitochondrial function, and…”
Get full text

Correlates of neutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics in BNT162b2-vaccinated individuals by Maeda, Kenji, Amano, Masayuki, Uemura, Yukari, Tsuchiya, Kiyoto, Matsushima, Tomoko, Noda, Kenta, Shimizu, Yosuke, Fujiwara, Asuka, Takamatsu, Yuki, Ichikawa, Yasuko, Nishimura, Hidehiro, Kinoshita, Mari, Matsumoto, Shota, Gatanaga, Hiroyuki, Yoshimura, Kazuhisa, Oka, Shin-ichi, Mikami, Ayako, Sugiura, Wataru, Sato, Toshiyuki, Yoshida, Tomokazu, Shimada, Shinya, Mitsuya, Hiroaki

“…While mRNA vaccines against SARS-CoV-2 are exceedingly effective in preventing symptomatic infection, their immune response features remain to be clarified. In…”
Get full text

Molecular properties and regulation of NAD+ kinase (NADK) by Oka, Shin-ichi, Titus, Allen Sam, Zablocki, Daniela, Sadoshima, Junichi

“…Nicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+, thereby producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK…”
Get full text

Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload by Ikeda, Shohei, Mizushima, Wataru, Sciarretta, Sebastiano, Abdellatif, Maha, Zhai, Peiyong, Mukai, Risa, Fefelova, Nadezhda, Oka, Shin-ichi, Nakamura, Michinari, Del Re, Dominic P, Farrance, Iain, Park, Ji Yeon, Tian, Bin, Xie, Lai-Hua, Kumar, Mohit, Hsu, Chiao-Po, Sadayappan, Sakthivel, Shimokawa, Hiroaki, Lim, Dae-Sik, Sadoshima, Junichi

“…RATIONALE:The Hippo pathway plays an important role in determining organ size through regulation of cell proliferation and apoptosis. Hippo inactivation and…”
Get full text

YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases by Ikeda, Shohei, Nah, Jihoon, Shirakabe, Akihiro, Zhai, Peiyong, Oka, Shin-Ichi, Sciarretta, Sebastiano, Guan, Kun-Liang, Shimokawa, Hiroaki, Sadoshima, Junichi

“…Lysosomal dysfunction caused by mutations in lysosomal genes results in lysosomal storage disorder (LSD), characterized by accumulation of damaged proteins and…”
Get full text

Regulation of Cell Survival and Death by Pyridine Nucleotides by Oka, Shin-ichi, Hsu, Chiao-Po, Sadoshima, Junichi

“…Pyridine nucleotides (PNs), such as NAD(H) and NADP(H), mediate electron transfer in many catabolic and anabolic processes. In general, NAD and NADP receive…”
Get full text

Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart by Warren, Junco S., Tracy, Christopher M., Miller, Mickey R., Makaju, Aman, Szulik, Marta W., Oka, Shin-ichi, Yuzyuk, Tatiana N., Cox, James E., Kumar, Anil, Lozier, Bucky K., Wang, Li, Llana, June García, Sabry, Amira D., Cawley, Keiko M., Barton, Dane W., Han, Yong Hwan, Boudina, Sihem, Fiehn, Oliver, Tucker, Haley O., Zaitsev, Alexey V., Franklin, Sarah

“…Smyd1, a muscle-specific histone methyltransferase, has established roles in skeletal and cardiac muscle development, but its role in the adult heart remains…”
Get full text

Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy by Oka, Shin-ichi, Byun, Jaemin, Huang, Chun-yang, Imai, Nobushige, Ralda, Guersom, Zhai, Peiyong, Xu, Xiaoyong, Kashyap, Sanchita, Warren, Junco S., Alan Maschek, John, Tippetts, Trevor S., Tong, Mingming, Venkatesh, Sundararajan, Ikeda, Yoshiyuki, Mizushima, Wataru, Kashihara, Toshihide, Sadoshima, Junichi

“…[Figure: see text]…”
Get full text

Both gain and loss of Nampt function promote pressure overload-induced heart failure by Byun, Jaemin, Oka, Shin-Ichi, Imai, Nobushige, Huang, Chun-Yang, Ralda, Guersom, Zhai, Peiyong, Ikeda, Yoshiyuki, Ikeda, Shohei, Sadoshima, Junichi

“…The heart requires high-energy production, but metabolic ability declines in the failing heart. Nicotinamide phosphoribosyl-transferase (Nampt) is a…”
Get more information

Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia by Nagarajan, Narayani, Oka, Shin-Ichi, Nah, Jihoon, Wu, Changgong, Zhai, Peiyong, Mukai, Risa, Xu, Xiaoyong, Kashyap, Sanchita, Huang, Chun-Yang, Sung, Eun-Ah, Mizushima, Wataru, Titus, Allen Sam, Takayama, Koichiro, Mourad, Youssef, Francisco, Jamie, Liu, Tong, Chen, Tong, Li, Hong, Sadoshima, Junichi

“…Modification of cysteine residues by oxidative and nitrosative stress affects structure and function of proteins, thereby contributing to the pathogenesis of…”
Get full text

Multiple Levels of PGC-1α Dysregulation in Heart Failure by Oka, Shin-Ichi, Sabry, Amira D, Cawley, Keiko M, Warren, Junco S

“…Metabolic adaption is crucial for the heart to sustain its contractile activity under various physiological and pathological conditions. At the molecular…”
Get full text

Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes by Oka, Shin-ichi, Hirata, Tsuyoshi, Suzuki, Wataru, Naito, Daichi, Chen, Yanbin, Chin, Adave, Yaginuma, Hiroaki, Saito, Toshiro, Nagarajan, Narayani, Zhai, Peiyong, Bhat, Santosh, Schesing, Kevin, Shao, Dan, Hirabayashi, Yoko, Yodoi, Junji, Sciarretta, Sebastiano, Sadoshima, Junichi

“…Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps…”
Get full text

An Ideal PPAR Response Element Bound to and Activated by PPARα by Tzeng, John, Byun, Jaemin, Park, Ji Yeon, Yamamoto, Takanobu, Schesing, Kevin, Tian, Bin, Sadoshima, Junichi, Oka, Shin-Ichi

“…Peroxisome proliferator-activated receptor-α (PPARα), a nuclear receptor, plays an important role in the transcription of genes involved in fatty acid…”
Get full text

PERM1 regulates genes involved in fatty acid metabolism in the heart by interacting with PPARα and PGC-1α by Huang, Chun-yang, Oka, Shin-ichi, Xu, Xiaoyong, Chen, Chian-Feng, Tung, Chien-Yi, Chang, Ya-Yuan, Mourad, Youssef, Vehra, Omair, Ivessa, Andreas, Yehia, Ghassan, Romanienko, Peter, Hsu, Chiao-Po, Sadoshima, Junichi

“…PERM1 (PGC-1/ERR-induced regulator in muscle 1) is a muscle-specific protein induced by PGC-1 and ERRs. Previous studies have shown that PERM1 promotes…”
Get full text

Redox Regulatory Mechanism of Transnitrosylation by Thioredoxin by Wu, Changgong, Liu, Tong, Chen, Wei, Oka, Shin-ichi, Fu, Cexiong, Jain, Mohit Raja, Parrott, Andrew Myles, Baykal, Ahmet Tarik, Sadoshima, Junichi, Li, Hong

“…Transnitrosylation and denitrosylation are emerging as key post-translational modification events in regulating both normal physiology and a wide spectrum of…”
Get full text

Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1 by Oka, Shin-Ichi, Sabry, Amira D, Horiuchi, Amanda K, Cawley, Keiko M, O'Very, Sean A, Zaitsev, Maria A, Shankar, Thirupura S, Byun, Jaemin, Mukai, Risa, Xu, Xiaoyong, Torres, Natalia S, Kumar, Anil, Yazawa, Masayuki, Ling, Jing, Taleb, Iosif, Saijoh, Yukio, Drakos, Stavros G, Sadoshima, Junichi, Warren, Junco S

“…The transcriptional regulatory machinery in mitochondrial bioenergetics is complex and is still not completely understood. We previously demonstrated that the…”
Get full text