Search Results - "Shin, Woojung"
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Intestinal barrier dysfunction orchestrates the onset of inflammatory host–microbiome cross-talk in a human gut inflammation-on-a-chip
Published in Proceedings of the National Academy of Sciences - PNAS (06-11-2018)“…The initiation of intestinal inflammation involves complex intercellular cross-talk of inflammatory cells, including the epithelial and immune cells, and the…”
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3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert
Published in Nature protocols (01-03-2022)“…Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially organized crypt–villus characteristics. This unique structure is…”
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Microfluidic Organ-on-a-Chip Models of Human Intestine
Published in Cellular and molecular gastroenterology and hepatology (01-01-2018)“…Microfluidic organ-on-a-chip models of human intestine have been developed and used to study intestinal physiology and pathophysiology. In this article, we…”
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Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip
Published in iScience (31-05-2019)“…We leveraged a human gut-on-a-chip (Gut Chip) microdevice that enables independent control of fluid flow and mechanical deformations to explore how physical…”
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Live probiotic bacteria administered in a pathomimetic Leaky Gut Chip ameliorate impaired epithelial barrier and mucosal inflammation
Published in Scientific reports (31-12-2022)“…Here, we report a pathomimetic Leaky Gut Chip that recapitulates increased epithelial permeability and intestinal inflammation to assess probiotic intervention…”
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Editorial: Advances in tissue repair and regeneration
Published in Frontiers in medical technology (03-11-2022)Get full text
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Recapitulation of the accessible interface of biopsy-derived canine intestinal organoids to study epithelial-luminal interactions
Published in PloS one (17-04-2020)“…Recent advances in canine intestinal organoids have expanded the option for building a better in vitro model to investigate translational science of intestinal…”
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A Robust Longitudinal Co-culture of Obligate Anaerobic Gut Microbiome With Human Intestinal Epithelium in an Anoxic-Oxic Interface-on-a-Chip
Published in Frontiers in bioengineering and biotechnology (07-02-2019)“…The majority of human gut microbiome is comprised of obligate anaerobic bacteria that exert essential metabolic functions in the human colon. These anaerobic…”
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"Good Fences Make Good Neighbors": How does the Human Gut Microchip Unravel Mechanism of Intestinal Inflammation?
Published in Gut microbes (03-05-2020)“…A microengineered human gut-on-a-chip has demonstrated intestinal physiology, three-dimensional (3D) epithelial morphogenesis, and longitudinal host-microbiome…”
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Three-Dimensional Regeneration of Patient-Derived Intestinal Organoid Epithelium in a Physiodynamic Mucosal Interface-on-a-Chip
Published in Micromachines (Basel) (07-07-2020)“…The regeneration of the mucosal interface of the human intestine is critical in the host-gut microbiome crosstalk associated with gastrointestinal diseases…”
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Single-cell transcriptomic mapping of intestinal epithelium that undergoes 3D morphogenesis and mechanodynamic stimulation in a gut-on-a-chip
Published in iScience (22-12-2022)“…The human gut-on-a-chip has demonstrated in vivo-relevant cellular fidelity and physiological functions of Caco-2 intestinal epithelium compared to its static…”
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Spatiotemporal Gradient and Instability of Wnt Induce Heterogeneous Growth and Differentiation of Human Intestinal Organoids
Published in iScience (21-08-2020)“…In a conventional culture of three-dimensional human intestinal organoids, extracellular matrix hydrogel has been used to provide a physical space for the…”
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Microphysiological Engineering of Immune Responses in Intestinal Inflammation
Published in Immune network (01-04-2020)“…The epithelial barrier in the gastrointestinal (GI) tract is a protective interface that endures constant exposure to the external environment while…”
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Robust Formation of an Epithelial Layer of Human Intestinal Organoids in a Polydimethylsiloxane-Based Gut-on-a-Chip Microdevice
Published in Frontiers in medical technology (07-08-2020)“…Polydimethylsiloxane (PDMS) is a silicone polymer that has been predominantly used in a human organ-on-a-chip microphysiological system. The hydrophobic…”
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Priming nanoparticle-guided diagnostics and therapeutics towards human organs-on-chips microphysiological system
Published in Nano Convergence (01-10-2016)“…Nanotechnology and bioengineering have converged over the past decades, by which the application of multi-functional nanoparticles (NPs) has been emerged in…”
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Turn-On Fluorescence Sensing of Oxygen with Dendrimer-Encapsulated Platinum Nanoparticles as Tunable Oxidase Mimics for Spatially Resolved Measurement of Oxygen Gradient in a Human Gut-on-a-Chip
Published in Analytical chemistry (Washington) (07-12-2021)“…Turn-on type fluorescence sensing of O2 is considered a promising approach to developing ways to measure O2 in microenvironments with spatially distributed O2…”
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Pathomimetic modeling of human intestinal diseases and underlying host-gut microbiome interactions in a gut-on-a-chip
Published in Methods in cell biology (2018)“…The gut-on-a-chip is a microengineered in vitro model of the living human intestine that reconstitutes the lumen-capillary tissue interface. Intestinal…”
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