Search Results - "Shin, Wangyong"

Early correction of synaptic long-term depression improves abnormal anxiety-like behavior in adult GluN2B-C456Y-mutant mice by Shin, Wangyong, Kim, Kyungdeok, Serraz, Benjamin, Cho, Yi Sul, Kim, Doyoun, Kang, Muwon, Lee, Eun-Jae, Lee, Hyejin, Bae, Yong Chul, Paoletti, Pierre, Kim, Eunjoon

“…Extensive evidence links Glutamate receptor, ionotropic, NMDA2B (GRIN2B), encoding the GluN2B/NR2B subunit of N-methyl-D-aspartate receptors (NMDARs), with…”
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Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons by Kim, Sun-Gyun, Lee, Suho, Kim, Yangsik, Park, Jieun, Woo, Doyeon, Kim, Dayeon, Li, Yan, Shin, Wangyong, Kang, Hyunjeong, Yook, Chaehyun, Lee, Minji, Kim, Kyungdeok, Roh, Junyeop Daniel, Ryu, Jeseung, Jung, Hwajin, Um, Seung Min, Yang, Esther, Kim, Hyun, Han, Jinju, Heo, Won Do, Kim, Eunjoon

“…mTOR signaling, involving mTORC1 and mTORC2 complexes, critically regulates neural development and is implicated in various brain disorders. However, we do not…”
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Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms by Kim, Kyungdeok, Shin, Wangyong, Kang, Muwon, Lee, Suho, Kim, Doyoun, Kang, Ryeonghwa, Jung, Yewon, Cho, Yisul, Yang, Esther, Kim, Hyun, Bae, Yong Chul, Kim, Eunjoon

“…Synaptic adhesion molecules regulate synapse development and function. However, whether and how presynaptic adhesion molecules regulate postsynaptic NMDAR…”
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Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation by Lee, Eun-Jae, Lee, Hyejin, Huang, Tzyy-Nan, Chung, Changuk, Shin, Wangyong, Kim, Kyungdeok, Koh, Jae-Young, Hsueh, Yi-Ping, Kim, Eunjoon

“…Genetic aspects of autism spectrum disorders (ASDs) have recently been extensively explored, but environmental influences that affect ASDs have received…”
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NGL-3 in the regulation of brain development, Akt/GSK3b signaling, long-term depression, and locomotive and cognitive behaviors by Lee, Hyejin, Shin, Wangyong, Kim, Kyungdeok, Lee, Suho, Lee, Eun-Jae, Kim, Jihye, Kweon, Hanseul, Lee, Eunee, Park, Haram, Kang, Muwon, Yang, Esther, Kim, Hyun, Kim, Eunjoon

“…Netrin-G ligand-3 (NGL-3) is a postsynaptic adhesion molecule known to directly interact with the excitatory postsynaptic scaffolding protein postsynaptic…”
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Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice by Kang, Ryeonghwa, Kim, Kyungdeok, Jung, Yewon, Choi, Sang-Han, Lee, Chanhee, Im, Geun Ho, Shin, Miram, Ryu, Kwangmin, Choi, Subin, Yang, Esther, Shin, Wangyong, Lee, Seungjoon, Lee, Suho, Papadopoulos, Zachary, Ahn, Ji Hoon, Koh, Gou Young, Kipnis, Jonathan, Kang, Hyojin, Kim, Hyun, Cho, Won-Ki, Park, Soochul, Kim, Seong-Gi, Kim, Eunjoon

“…Autism spectrum disorders (ASD) frequently accompany macrocephaly, which often involves hydrocephalic enlargement of brain ventricles. Katnal2 is a…”
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NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation by Um, Seung Min, Ha, Seungmin, Lee, Hyejin, Kim, Jihye, Kim, Kyungdeok, Shin, Wangyong, Cho, Yi Sul, Roh, Junyeop Daniel, Kang, Jaeseung, Yoo, Taesun, Noh, Young Woo, Choi, Yeonsoo, Bae, Yong Chul, Kim, Eunjoon

“…Netrin-G ligand 2 (NGL-2)/LRRC4, implicated in autism spectrum disorders and schizophrenia, is a leucine-rich repeat-containing postsynaptic adhesion molecule…”
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Distinct features of B cell receptors in neuromyelitis optica spectrum disorder among CNS inflammatory demyelinating diseases by Kim, Hyo Jae, Park, Jong-Eun, Shin, Wangyong, Seo, Dayoung, Kim, Seungmi, Kim, Hyunji, Noh, Jinsung, Lee, Yonghee, Kim, Hyunjin, Lim, Young-Min, Kim, Hyori, Lee, Eun-Jae

“…Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) stands out among CNS inflammatory demyelinating diseases (CIDDs) due to its unique disease…”
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Author Correction: Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons by Kim, Sun-Gyun, Lee, Suho, Kim, Yangsik, Park, Jieun, Woo, Doyeon, Kim, Dayeon, Li, Yan, Shin, Wangyong, Kang, Hyunjeong, Yook, Chaehyun, Lee, Minji, Kim, Kyungdeok, Roh, Junyeop Daniel, Ryu, Jeseung, Jung, Hwajin, Um, Seung Min, Yang, Esther, Kim, Hyun, Han, Jinju, Heo, Won Do, Kim, Eunjoon

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Magnetic transferrin nanoparticles (MTNs) assay as a novel isolation approach for exosomal biomarkers in neurological diseases by Jang, Yoon Ok, Ahn, Hee-Sung, Dao, Thuy Nguyen Thi, Hong, JeongYeon, Shin, Wangyong, Lim, Young-Min, Chung, Sun Ju, Lee, Jae-Hong, Liu, Huifang, Koo, Bonhan, Kim, Myoung Gyu, Kim, Kyunggon, Lee, Eun-Jae, Shin, Yong

“…Brain-derived exosomes released into the blood are considered a liquid biopsy to investigate the pathophysiological state, reflecting the aberrant…”
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Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory by Shin, Wangyong, Kweon, Hanseul, Kang, Ryeonghwa, Kim, Doyoun, Kim, Kyungdeok, Kang, Muwon, Kim, Seo Yeong, Hwang, Sun Nam, Kim, Jin Yong, Yang, Esther, Kim, Hyun, Kim, Eunjoon

“…Nav1.2, a voltage-gated sodium channel subunit encoded by the gene, has been implicated in various brain disorders, including epilepsy, autism spectrum…”
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DISTINCT CHANGES OF SYNAPSE, TRANSCRIPTOMES, AND POST-TRANSLATIONAL MODIFICATIONS IN MICE BRAIN UPON HUMAN BLOOD BETWEEN APOE4 CARRIERS AND NON-CARRIERS by Choi, Lynkyung, Shin, Wangyong, Kim, Seungmi, Kim, Hyunji, Seo, Dayoung, Lee, Seungjoon, Kang, Hyojin, Lee, Jae-Hong, Jo, Sungyang, Lee, Seungjoo, Yoon, Seung-Yong, Lee, Eun-Jae, Kim, Eunjoon

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SALM4 negatively regulates NMDA receptor function and fear memory consolidation by Lie, Eunkyung, Yeo, Yeji, Lee, Eun-Jae, Shin, Wangyong, Kim, Kyungdeok, Han, Kyung Ah, Yang, Esther, Choi, Tae-Yong, Bae, Mihyun, Lee, Suho, Um, Seung Min, Choi, Se-Young, Kim, Hyun, Ko, Jaewon, Kim, Eunjoon

“…Many synaptic adhesion molecules positively regulate synapse development and function, but relatively little is known about negative regulation. SALM4/Lrfn3…”
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Early and Late Corrections in Mouse Models of Autism Spectrum Disorder by Chung, Changuk, Shin, Wangyong, Kim, Eunjoon

“…Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and repetitive symptoms. A key feature of ASD is early-life…”
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Cell-Type-Specific Shank2 Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes by Kim, Ryunhee, Kim, Jihye, Chung, Changuk, Ha, Seungmin, Lee, Seungjoon, Lee, Eunee, Yoo, Ye-Eun, Kim, Woohyun, Shin, Wangyong, Kim, Eunjoon

“…Shank2 is an excitatory postsynaptic scaffolding protein implicated in synaptic regulation and psychiatric disorders including autism spectrum disorders…”
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Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in Grin2b-mutant mice by Lee, Soowon, Jung, Won Beom, Moon, Heera, Im, Geun Ho, Noh, Young Woo, Shin, Wangyong, Kim, Yong Gyu, Yi, Jee Hyun, Hong, Seok Jun, Jung, Yongwhan, Ahn, Sunjoo, Kim, Seong-Gi, Kim, Eunjoon

“…Sensory abnormalities are observed in ~90% of individuals with autism spectrum disorders (ASD), but the underlying mechanisms are poorly understood. GluN2B, an…”
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Transferrin-conjugated magnetic nanoparticles for the isolation of brain-derived blood exosomal MicroRNAs: A novel approach for Parkinson's disease diagnosis by Jang, Yoon Ok, Roh, Yeonjeong, Shin, Wangyong, Jo, Sungyang, Koo, Bonhan, Liu, Huifang, Kim, Myoung Gyu, Lee, Hyo Joo, Qiao, Zhen, Lee, Eun Yeong, Lee, Minju, Lee, Joonseok, Lee, Eun-Jae, Shin, Yong

“…Brain-derived exosomes circulate in the bloodstream and other bodily fluids, serving as potential indicators of neurological disease progression. These…”
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Turnover of fear engram cells by repeated experience by Cho, Hye-Yeon, Shin, Wangyong, Lee, Han-Sol, Lee, Yeji, Kim, Mujun, Oh, Jung-Pyo, Han, Junho, Jeong, Yire, Suh, Boin, Kim, Eunjoon, Han, Jin-Hee

“…A sparse population of neurons active during a learning event has been identified as memory engram cells. However, cells that are recruited to support memory…”
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Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice by Farsi, Zohreh, Nicolella, Ally, Simmons, Sean K., Aryal, Sameer, Shepard, Nate, Brenner, Kira, Lin, Sherry, Herzog, Linnea, Moran, Sean P., Stalnaker, Katherine J., Shin, Wangyong, Gazestani, Vahid, Song, Bryan J., Bonanno, Kevin, Keshishian, Hasmik, Carr, Steven A., Pan, Jen Q., Macosko, Evan Z., Datta, Sandeep Robert, Dejanovic, Borislav, Kim, Eunjoon, Levin, Joshua Z., Sheng, Morgan

“…A genetically valid animal model could transform our understanding of schizophrenia (SCZ) disease mechanisms. Rare heterozygous loss-of-function (LoF)…”
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Presynaptic PTP[sigma] regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms by Kim, Kyungdeok, Shin, Wangyong, Kang, Muwon, Lee, Suho, Kim, Doyoun, Kang, Ryeonghwa, Jung, Yewon, Cho, Yisul, Yang, Esther, Kim, Hyun, Bae, Yong Chul, Kim, Eunjoon

“…Synaptic adhesion molecules regulate synapse development and function. However, whether and how presynaptic adhesion molecules regulate postsynaptic NMDAR…”
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