Search Results - "Shin, Tahiro"

CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice by Wang, Long, Fan, Jie, Thompson, Linda F, Zhang, Yi, Shin, Tahiro, Curiel, Tyler J, Zhang, Bin

“…CD73 is overexpressed in many types of human and mouse cancers and is implicated in the control of tumor progression. However, the specific contribution from…”
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PD-1 suppresses protective immunity to Streptococcus pneumoniae through a B cell-intrinsic mechanism by McKay, Jerome T, Egan, Ryan P, Yammani, Rama D, Chen, Lieping, Shin, Tahiro, Yagita, Hideo, Haas, Karen M

“…Despite the emergence of the programmed cell death 1 (PD-1):PD-1 ligand (PD-L) regulatory axis as a promising target for treating multiple human diseases,…”
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B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses by Lin, Pei-Yi, Sun, Lishi, Thibodeaux, Suzanne R, Ludwig, Sara M, Vadlamudi, Ratna K, Hurez, Vincent J, Bahar, Rumana, Kious, Mark J, Livi, Carolina B, Wall, Shawna R, Chen, Lieping, Zhang, Bin, Shin, Tahiro, Curiel, Tyler J

“…CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) are immunopathogenic in cancers by impeding tumor-specific immunity. B7-homologue 1 (B7-H1) (CD274) is a…”
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Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice by HUREZ, Vincent, DANIEL, Benjamin J, WALL, Shawna, BRUMLIK, Michael J, SHIN, Tahiro, BIN ZHANG, CURIEL, Tyler J, LISHI SUN, LIU, Ai-Jie, LUDWIG, Sara M, KIOUS, Mark J, THIBODEAUX, Suzanne R, PANDESWARA, Srilakshmi, MURTHY, Kruthi, LIVI, Carolina B

“…Although cancer tends to affect the elderly, most preclinical studies are carried out in young subjects. In this study, we developed a melanoma-specific cancer…”
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PDL1 Is Required for Peripheral Transplantation Tolerance and Protection from Chronic Allograft Rejection by Tanaka, Katsunori, Albin, Monica J, Yuan, Xueli, Yamaura, Kazuhiro, Habicht, Antje, Murayama, Takaya, Grimm, Martin, Waaga, Ana Maria, Ueno, Takuya, Padera, Robert F, Yagita, Hideo, Azuma, Miyuki, Shin, Tahiro, Blazar, Bruce R, Rothstein, David M, Sayegh, Mohamed H, Najafian, Nader

“…The PD-1:PDL pathway plays an important role in regulating alloimmune responses but its role in transplantation tolerance is unknown. We investigated the role…”
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Costimulator B7-DC Attenuates Strong Th2 Responses Induced by Nippostrongylus brasiliensis by Ishiwata, Kenji, Watanabe, Naohiro, Guo, Miao, Tomihara, Kei, Brumlik, Michael J, Yagita, Hideo, Pardoll, Drew, Chen, Lieping, Shin, Tahiro

“…The caliber and magnitude of T cell responses are regulated by costimulatory molecules following the engagement of TCRs and MHC molecules. B7-DC has the…”
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Critical Role of Donor Tissue Expression of Programmed Death Ligand-1 in Regulating Cardiac Allograft Rejection and Vasculopathy by JUN YANG, POPOOLA, Joyce, SHIN, Tahiro, YAGITA, Hideo, AZUMA, Miyuki, SAYEGH, Mohamed H, CHANDRAKER, Anil, KHANDWALA, Shakila, VADIVEL, Nidyanandh, VANGURI, Vijay, XUELI YUAN, DADA, Shirine, GULERIA, Indira, TIAN, Chaorui, JAVEED ANSARI, M

“…Allograft vasculopathy is a major limiting factor in the long-term success of cardiac transplantation. T cells play a critical role in initiation of cardiac…”
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Synergistic In vivo Antitumor Effect of the Histone Deacetylase Inhibitor MS-275 in Combination with Interleukin 2 in a Murine Model of Renal Cell Carcinoma by KATO, Yukihiko, YOSHIMURA, Kiyoshi, SHIN, Tahiro, VERHEUL, Henk, HAMMERS, Hans, SANNI, Tolib B, SALUMBIDES, Brenda C, VAN ERP, Karen, SCHULICK, Richard, PILI, Roberto

“…Purpose: High-dose interleukin 2 (IL-2) is a Food and Drug Administration–approved regimen for patients with metastatic renal cell carcinoma. However, the…”
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Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells by Tomihara, Kei, Guo, Miao, Shin, Takako, Sun, Xiuhua, Ludwig, Sara M, Brumlik, Michael J, Zhang, Bin, Curiel, Tyler J, Shin, Tahiro

“…Both innate and adaptive immune systems are considered important for cancer prevention, immunosurveillance, and control of cancer progression. It is known…”
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Cutting Edge: Expression of Functional CD137 Receptor by Dendritic Cells by Wilcox, Ryan A, Chapoval, Andrei I, Gorski, Kevin S, Otsuji, Mizuto, Shin, Tahiro, Flies, Dallas B, Tamada, Koji, Mittler, Robert S, Tsuchiya, Haruo, Pardoll, Drew M, Chen, Lieping

“…Interaction between dendritic cells (DCs) and T cells is a prerequisite for the initiation of a T cell response. The molecular nature of this interaction…”
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Aging‐associated B7‐DC+ B cells enhance anti‐tumor immunity via Th1 and Th17 induction by Tomihara, Kei, Shin, Takako, Hurez, Vincent J., Yagita, Hideo, Pardoll, Drew M., Zhang, Bin, Curiel, Tyler J., Shin, Tahiro

“…Summary Because most patients with cancer are aged and because immunological functions are altered during aging, it is important to account for…”
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B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma by Matsumoto, Koichiro, Fukuyama, Satoru, Eguchi-Tsuda, Miyuki, Nakano, Takako, Matsumoto, Takafumi, Matsumura, Mikiko, Moriwaki, Atsushi, Kan-o, Keiko, Wada, Yoshihiro, Yagita, Hideo, Shin, Tahiro, Pardoll, Drew M., Patcharee, Rirprajak, Azuma, Miyuki, Nakanishi, Yoichi, Inoue, Hiromasa

“…B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that treatment with anti-B7-DC mAb during the effector phase enhances asthma…”
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Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells by Nguyen, Loc T, Radhakrishnan, Suresh, Ciric, Bogoljub, Tamada, Koji, Shin, Tahiro, Pardoll, Drew M, Chen, Lieping, Rodriguez, Moses, Pease, Larry R

“…B7-DC molecules are known to function as ligands on antigen-presenting cells (APCs), enhancing T cell activation. In this study, cross-linking B7-DC with the…”
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CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression by DACHUAN JIN, JIE FAN, LONG WANG, THOMPSON, Linda F, AIJIE LIU, DANIEL, Benjamin J, SHIN, Tahiro, CURIEL, Tyler J, BIN ZHANG

“…CD73, originally defined as a lymphocyte differentiation antigen, is thought to function as a cosignaling molecule on T lymphocytes and an adhesion molecule…”
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Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy by Tsushima, Fumihiko, Yao, Sheng, Shin, Tahiro, Flies, Andrew, Flies, Sarah, Xu, Haiying, Tamada, Koji, Pardoll, Drew M., Chen, Lieping

“…Although self-reactive T-cell precursors can be eliminated upon recognition of self-antigen presented in the thymus, this central tolerance process is often…”
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PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE by Schreiner, Bettina, Bailey, Samantha L, Shin, Tahiro, Chen, Lieping, Miller, Stephen D

“…Disease progression in experimental autoimmune encephalomyelitis (EAE) is regulated by programmed death receptor 1 (PD-1) and its ligands, B7-H1 (programmed…”
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Expression of Programmed Death 1 Ligands by Murine T Cells and APC by Yamazaki, Tomohide, Akiba, Hisaya, Iwai, Hideyuki, Matsuda, Hironori, Aoki, Mami, Tanno, Yuka, Shin, Tahiro, Tsuchiya, Haruo, Pardoll, Drew M, Okumura, Ko, Azuma, Miyuki, Yagita, Hideo

“…Programmed death 1 (PD-1) is a new member of the CD28/CTLA-4 family, which has been implicated in the maintenance of peripheral tolerance. Two ligands for…”
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Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL‐17 producing T cells by Sun, Lishi, Hurez, Vincent J., Thibodeaux, Suzanne R., Kious, Mark J., Liu, Aijie, Lin, Peiyi, Murthy, Kruthi, Pandeswara, Srilakshmi, Shin, Tahiro, Curiel, Tyler J.

“…Summary Regulatory T cells (Tregs) are specialized CD4+ T lymphocytes helping defend against autoimmunity and inflammation. Although age is associated with…”
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Inhibition of tumor metastasis by adoptive transfer of IL-12-activated V?14 NKT cells by Shin, Tahiro, Nakayama, Toshinori, Akutsu, Yasunori, Motohashi, Shinichiro, Shibata, Youichi, Harada, Michishige, Kamada, Noriaki, Shimizu, Chiori, Shimizu, Eiko, Saito, Tsuyoshi, Ochiai, Takenori, Taniguchi, Masaru

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Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance by Fukaya, Tomohiro, Takagi, Hideaki, Sato, Yumiko, Sato, Kaori, Eizumi, Kawori, Taya, Honami, Shin, Tahiro, Chen, Lieping, Dong, Chen, Azuma, Miyuki, Yagita, Hideo, Malissen, Bernard, Sato, Katsuaki

“…Oral tolerance is a key feature of intestinal immunity, generating systemic tolerance to fed antigens. However, the molecular mechanism mediating oral…”
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