Search Results - "Shin, Myung K."

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments by Sheng, Xin, Guan, Yuting, Ma, Ziyuan, Wu, Junnan, Liu, Hongbo, Qiu, Chengxiang, Vitale, Steven, Miao, Zhen, Seasock, Matthew J., Palmer, Matthew, Shin, Myung K., Duffin, Kevin L., Pullen, Steven S., Edwards, Todd L., Hellwege, Jacklyn N., Hung, Adriana M., Li, Mingyao, Voight, Benjamin F., Coffman, Thomas M., Brown, Christopher D., Susztak, Katalin

“…The functional interpretation of genome-wide association studies (GWAS) is challenging due to the cell-type-dependent influences of genetic variants. Here, we…”
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Epilation induces hair and skin pigmentation through an EDN3/EDNRB-dependent regenerative response of melanocyte stem cells by Li, Huirong, Fan, Lilv, Zhu, Shanpu, Shin, Myung K., Lu, Fan, Qu, Jia, Hou, Ling

“…In response to various types of injury, melanocyte stem cells (McSCs) located in the bulge of hair follicles can regenerate mature melanocytes for hair and…”
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Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys by Blessing, Natalya A, Wu, Zhenzhen, Madhavan, Sethu M, Choy, Jonathan W, Chen, Michelle, Shin, Myung K, Hoek, Maarten, Sedor, John R, O'Toole, John F, Bruggeman, Leslie A

“…The mechanism of pathogenesis associated with APOL1 polymorphisms and risk for non-diabetic chronic kidney disease (CKD) is not fully understood. Prior studies…”
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Impact of perceived contraceptive policy changes on long acting reversible contraception dispensing trends by Sridhar, Aparna, Friedman, Sarah R., Sim, Myung-Shin K., Troung, William, Elias, Sam

“…We observed the long-term trend of Long Acting Reversible Contraception (LARC) usage before and after the 2016 presidential election. We observed the rate of…”
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Characterization of multidrug resistance 1a/P-glycoprotein knockout rats generated by zinc finger nucleases by Chu, Xiaoyan, Zhang, Zuo, Yabut, Jocelyn, Horwitz, Sarah, Levorse, John, Li, Xiang-qing, Zhu, Lei, Lederman, Harmony, Ortiga, Rachel, Strauss, John, Li, Xiaofang, Owens, Karen A, Dragovic, Jasminka, Vogt, Thomas, Evers, Raymond, Shin, Myung K

“…The development of zinc finger nuclease (ZFN) technology has enabled the genetic engineering of the rat genome. The ability to manipulate the rat genome has…”
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Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors by Mundell, Nathan A., Plank, Jennifer L., LeGrone, Alison W., Frist, Audrey Y., Zhu, Lei, Shin, Myung K., Southard-Smith, E. Michelle, Labosky, Patricia A.

“…The enteric nervous system (ENS) arises from the coordinated migration, expansion and differentiation of vagal and sacral neural crest progenitor cells. During…”
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The endothelin receptor-B is required for the migration of neural crest-derived melanocyte and enteric neuron precursors by Lee, Hyung-Ok, Levorse, John M., Shin, Myung K.

“…Mutations in the genes encoding endothelin receptor-B ( Ednrb) and its ligand endothelin-3 ( Edn3) affect the development of two neural crest-derived cell…”
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Titrating haemophilia B phenotypes using siRNA strategy: evidence that antithrombotic activity is separated from bleeding liability by Metzger, Joseph M, Tadin-Strapps, Marija, Thankappan, Anil, Strapps, Walter R, DiPietro, Marti, Leander, Karen, Zhang, Zuo, Shin, Myung K, Levorse, John, Desai, Kunal, Xu, Yiming, Lai, KehDih, Wu, Weizhen, Chen, Zhu, Cai, Tian-Quan, Jochnowitz, Nina, Bentley, Ross, Hoos, Lizbeth, Zhou, Yuchen, Sepp-Lorenzino, Laura, Seiffert, Dietmar, Andre, Patrick

“…Haemophilia A and B are characterised by a life-long bleeding predisposition, and several lines of evidence suggest that risks of atherothrombotic events may…”
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Spatiotemporal regulation of endothelin receptor-B by SOX10 in neural crest-derived enteric neuron precursors by Shin, Myung K, Zhu, Lei, Lee, Hyung-Ok, Jordan, ChaRandle S, Cantrell, V Ashley, Southard-Smith, E Michelle

“…Hirschsprung disease (HSCR) is a multigenic, congenital disorder that affects 1 in 5,000 newborns and is characterized by the absence of neural crest-derived…”
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PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models by Ellwood-Yen, Katharine, Keilhack, Heike, Kunii, Kaiko, Dolinski, Brian, Connor, Yamicia, Hu, Kun, Nagashima, Kumiko, O'Hare, Erin, Erkul, Yusuf, Di Bacco, Alessandra, Gargano, Diana, Shomer, Nirah H, Angagaw, Minilik, Leccese, Erica, Andrade, Paula, Hurd, Melissa, Shin, Myung K, Vogt, Thomas F, Northrup, Alan, Bobkova, Ekaterina V, Kasibhatla, Shailaja, Bronson, Roderick T, Scott, Martin L, Draetta, Giulio, Richon, Victoria, Kohl, Nancy, Blume-Jensen, Peter, Andersen, Jannik N, Kraus, Manfred

“…PDK1 activates AKT suggesting that PDK1 inhibition might suppress tumor development. However, while PDK1 has been investigated intensively as an oncology…”
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Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release by Lin, Hua V, Chen, Dunlu, Shen, Zhu, Zhu, Lei, Ouyang, Xuesong, Vongs, Aurawan, Kan, Yanqing, Levorse, John M, Kowalik, Jr, Edward J, Szeto, Daphne M, Yao, Xiaorui, Xiao, Jianying, Chen, Shirley, Liu, Jinqi, Garcia-Calvo, Marga, Shin, Myung K, Pinto, Shirly

“…Diacylglycerol acyltransferase-1 (DGAT1) is a potential therapeutic target for treatment of obesity and related metabolic diseases. However, the degree of…”
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Cell-autonomous and cell non-autonomous signaling through endothelin receptor B during melanocyte development by Hou, Ling, Pavan, William J, Shin, Myung K, Arnheiter, Heinz

“…The endothelin receptor B gene ( Ednrb ) encodes a G-protein-coupled receptor that is expressed in a variety of cell types and is specifically required for the…”
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APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice by Ryu, Jung-Hwa, Ge, Mengyuan, Merscher, Sandra, Rosenberg, Avi Z, Desante, Marco, Roshanravan, Hila, Okamoto, Koji, Shin, Myung K, Hoek, Maarten, Fornoni, Alessia, Kopp, Jeffrey B

“…Apolipoprotein L1 (APOL1) genetic variants G1 and G2, compared to the common allele G0, are major risk factors for non-diabetic kidney disease in African…”
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APOL1 risk variants affect podocyte lipid homeostasis and energy production in focal segmental glomerulosclerosis by Ge, Mengyuan, Molina, Judith, Ducasa, G Michelle, Mallela, Shamroop K, Varona Santos, Javier, Mitrofanova, Alla, Kim, Jin-Ju, Liu, Xiaochen, Sloan, Alexis, Mendez, Armando J, Banerjee, Santanu, Liu, Shaoyi, Szeto, Hazel H, Shin, Myung K, Hoek, Maarten, Kopp, Jeffrey B, Fontanesi, Flavia, Merscher, Sandra, Fornoni, Alessia

“…Abstract Lipotoxicity was recently reported in several forms of kidney disease, including focal segmental glomerulosclerosis (FSGS). Susceptibility to FSGS in…”
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DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates by McLaren, David G., Han, Seongah, Murphy, Beth Ann, Wilsie, Larissa, Stout, Steven J., Zhou, Haihong, Roddy, Thomas P., Gorski, Judith N., Metzger, Daniel E., Shin, Myung K., Reilly, Dermot F., Zhou, Heather H., Tadin-Strapps, Marija, Bartz, Steven R., Cumiskey, Anne-Marie, Graham, Thomas H., Shen, Dong-Ming, Akinsanya, Karen O., Previs, Stephen F., Imbriglio, Jason E., Pinto, Shirly

“…Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step in triglyceride (TG) synthesis and has been shown to play a role in regulating hepatic…”
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APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R by Okamoto, Koji, Rausch, Jason W., Wakashin, Hidefumi, Fu, Yulong, Chung, Joon-Yong, Dummer, Patrick D., Shin, Myung K., Chandra, Preeti, Suzuki, Kosuke, Shrivastav, Shashi, Rosenberg, Avi Z., Hewitt, Stephen M., Ray, Patricio E., Noiri, Eisei, Le Grice, Stuart F. J., Hoek, Maarten, Han, Zhe, Winkler, Cheryl A., Kopp, Jeffrey B.

“…APOL1 risk alleles associate with chronic kidney disease in African Americans, but the mechanisms remain to be fully understood. We show that APOL1 risk…”
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Factor XII full and partial null in rat confers robust antithrombotic efficacy with no bleeding by Cai, Tian-Quan, Wu, Weizhen, Shin, Myung K, Xu, Yiming, Jochnowitz, Nina, Zhou, Yuchen, Hoos, Lizbeth, Bentley, Ross, Strapps, Walter, Thankappan, Anil, Metzger, Joseph M, Ogletree, Martin L, Tadin-Strapps, Marija, Seiffert, Dietmar A, Chen, Zhu

“…This report aims at exploring quantitatively the relationship between FXII inhibition and thromboprotection. FXII full and partial null in rats were…”
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High-Throughput Screening to Identify Small Molecules That Selectively Inhibit APOL1 Protein Level in Podocytes by Choy, Jonathan, Kan, Yanqing, Cifelli, Steve, Johnson, Josephine, Chen, Michelle, Shiao, Lin-Lin, Zhou, Haihong, Previs, Stephen, Lei, Ying, Johnstone, Richard, Liaw, Andy, Saigal, Ashmita, Hu, Lufei, Ramos, Robert, Visconti, Richard, McElroy, William T, Kreamer, Anthony, Wildey, Mary-Jo, Peier, Andrea, Shin, Myung K, Imbriglio, Jason, Ren, Zhao, Hoek, Maarten, Weinglass, Adam, Ai, Xi

“…High-throughput phenotypic screening is a key driver for the identification of novel chemical matter in drug discovery for challenging targets, especially for…”
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The temporal requirement for endothelin receptor-B signalling during neural crest development by Tilghman, Shirley M, Shin, Myung K, Levorse, John M, Ingram, Robert S

“…Endothelin receptor B (EDNRB) is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric…”
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Meiotic functions of RAD18 by Inagaki, Akiko, Sleddens-Linkels, Esther, Wassenaar, Evelyne, Ooms, Marja, van Cappellen, Wiggert A, Hoeijmakers, Jan H J, Seibler, Jost, Vogt, Thomas F, Shin, Myung K, Grootegoed, J Anton, Baarends, Willy M

“…RAD18 is an ubiquitin ligase that is involved in replication damage bypass and DNA double-strand break (DSB) repair processes in mitotic cells. Here, we…”
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