Search Results - "Shin, Dong M."

Visualization of the Cellular Uptake and Trafficking of DNA Origami Nanostructures in Cancer Cells by Wang, Pengfei, Rahman, Mohammad Aminur, Zhao, Zhixiang, Weiss, Kristin, Zhang, Chao, Chen, Zhengjia, Hurwitz, Selwyn J, Chen, Zhuo G, Shin, Dong M, Ke, Yonggang

“…DNA origami is a promising molecular delivery system for a variety of therapeutic applications including cancer therapy, given its capability to fabricate…”
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Nanoparticle therapeutics: an emerging treatment modality for cancer by Davis, Mark E, Chen, Zhuo (Georgia), Shin, Dong M

“…Key Points Nanoparticles are emerging as a new class of therapeutics for cancer because they can perform in ways that other therapeutic modalities cannot…”
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Therapeutic Nanoparticles for Drug Delivery in Cancer by CHO, Kwangjae, XU WANG, SHUMING NIE, ZHUO CHEN, SHIN, Dong M

“…Cancer nanotherapeutics are rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as…”
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A Reexamination of Active and Passive Tumor Targeting by Using Rod-Shaped Gold Nanocrystals and Covalently Conjugated Peptide Ligands by Huang, Xiaohua, Peng, Xianghong, Wang, Yiqing, Wang, Yuxiang, Shin, Dong M, El-Sayed, Mostafa A, Nie, Shuming

“…The targeted delivery of nanoparticles to solid tumors is one of the most important and challenging problems in cancer nanomedicine, but the detailed delivery…”
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Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth by Jin, Lingtao, Li, Dan, Alesi, Gina N., Fan, Jun, Kang, Hee-Bum, Lu, Zhou, Boggon, Titus J., Jin, Peng, Yi, Hong, Wright, Elizabeth R., Duong, Duc, Seyfried, Nicholas T., Egnatchik, Robert, DeBerardinis, Ralph J., Magliocca, Kelly R., He, Chuan, Arellano, Martha L., Khoury, Hanna J., Shin, Dong M., Khuri, Fadlo R., Kang, Sumin

“…How mitochondrial glutaminolysis contributes to redox homeostasis in cancer cells remains unclear. Here we report that the mitochondrial enzyme glutamate…”
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Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery by Sinha, Rajni, Kim, Gloria J, Nie, Shuming, Shin, Dong M

“…Nanotechnology refers to the interactions of cellular and molecular components and engineered materials—typically, clusters of atoms, molecules, and molecular…”
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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth by Hitosugi, Taro, Zhou, Lu, Elf, Shannon, Fan, Jun, Kang, Hee-Bum, Seo, Jae Ho, Shan, Changliang, Dai, Qing, Zhang, Liang, Xie, Jianxin, Gu, Ting-Lei, Jin, Peng, Alečković, Masa, LeRoy, Gary, Kang, Yibin, Sudderth, Jessica A., DeBerardinis, Ralph J., Luan, Chi-Hao, Chen, Georgia Z., Muller, Susan, Shin, Dong M., Owonikoko, Taofeek K., Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Ye, Keqiang, Boggon, Titus J., Kang, Sumin, He, Chuan, Chen, Jing

“…It is unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly growing tumors. We found that the glycolytic enzyme phosphoglycerate…”
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Systemic Delivery of Bc12‐Targeting siRNA by DNA Nanoparticles Suppresses Cancer Cell Growth by Rahman, Mohammad Aminur, Wang, Pengfei, Zhao, Zhixiang, Wang, Dongsheng, Nannapaneni, Sreenivas, Zhang, Chao, Chen, Zhengjia, Griffith, Christopher C., Hurwitz, Selwyn J., Chen, Zhuo G., Ke, Yonggang, Shin, Dong M.

“…Short interfering RNA (siRNA) is a promising molecular tool for cancer therapy, but its clinical success is limited by the lack of robust in vivo delivery…”
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Perspectives for Cancer Prevention With Natural Compounds by RUHUL AMIN, A. R. M, KUCUK, Omer, KHURI, Fadlo R, SHIN, Dong M

“…Cancer is the second leading cause of death in the United States. Despite the estimated 565,650 deaths in 2008 of Americans as a result of cancer, it is mostly…”
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Detection of Circulating Tumor Cells in Human Peripheral Blood Using Surface-Enhanced Raman Scattering Nanoparticles by XU WANG, XIMEI QIAN, BEITLER, Jonathan J, ZHUO GEORGIA CHEN, KHURI, Fadlo R, LEWIS, Melinda M, SHIN, Hyung Ju C, SHUMING NIE, SHIN, Dong M

“…The detection and characterization of circulating tumor cells (CTC) holds great promise for personalizing medicine and optimizing systemic therapy. However,…”
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Targeted Iron-Oxide Nanoparticle for Photodynamic Therapy and Imaging of Head and Neck Cancer by Wang, Dongsheng, Fei, Baowei, Halig, Luma V, Qin, Xulei, Hu, Zhongliang, Xu, Hong, Wang, Yongqiang Andrew, Chen, Zhengjia, Kim, Sungjin, Shin, Dong M, Chen, Zhuo (Georgia)

“…Photodynamic therapy (PDT) is a highly specific anticancer treatment modality for various cancers, particularly for recurrent cancers that no longer respond to…”
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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation by Jin, Lingtao, Chun, Jaemoo, Pan, Chaoyun, Li, Dan, Lin, Ruiting, Alesi, Gina N., Wang, Xu, Kang, Hee-Bum, Song, Lina, Wang, Dongsheng, Zhang, Guojing, Fan, Jun, Boggon, Titus J., Zhou, Lu, Kowalski, Jeanne, Qu, Cheng-Kui, Steuer, Conor E., Chen, Georgia Z., Saba, Nabil F., Boise, Lawrence H., Owonikoko, Taofeek K., Khuri, Fadlo R., Magliocca, Kelly R., Shin, Dong M., Lonial, Sagar, Kang, Sumin

“…Platinum-based chemotherapeutics represent a mainstay of cancer therapy, but resistance limits their curative potential. Through a kinome RNAi screen, we…”
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New Perspectives of Curcumin in Cancer Prevention by PARK, Wungki, RUHUL AMIN, A. R. M, GEORGIA CHEN, Zhuo, SHIN, Dong M

“…Numerous natural compounds have been extensively investigated for their potential for cancer prevention over the decades. Curcumin, from Curcuma longa, is a…”
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Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1 by Pan, Chaoyun, Kang, JiHoon, Hwang, Jung Seok, Li, Jie, Boese, Austin C., Wang, Xu, Yang, Likun, Boggon, Titus J., Chen, Georgia Z., Saba, Nabil F., Shin, Dong M., Magliocca, Kelly R., Jin, Lingtao, Kang, Sumin

“…Agonists of glucocorticoid receptor (GR) are frequently given to cancer patients with platinum-containing chemotherapy to reduce inflammation, but how GR…”
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Paranasal sinus squamous cell carcinoma incidence and survival based on Surveillance, Epidemiology, and End Results data, 1973 to 2009 by Ansa, Benjamin, Goodman, Michael, Ward, Kevin, Kono, Scott A., Owonikoko, Taofeek K., Higgins, Kristin, Beitler, Jonathan J., Grist, William, Wadsworth, Trad, El‐Deiry, Mark, Chen, Amy Y., Khuri, Fadlo Raja, Shin, Dong M., Saba, Nabil F.

“…BACKGROUND Paranasal sinus squamous cell carcinomas (PNSSCC) account for 3% of all head and neck malignancies. There has been little information on the trends…”
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Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy by Han, Bingshe, Park, Dongkyoo, Li, Rui, Xie, Maohua, Owonikoko, Taofeek K., Zhang, Guojing, Sica, Gabriel L., Ding, Chunyong, Zhou, Jia, Magis, Andrew T., Chen, Zhuo G., Shin, Dong M., Ramalingam, Suresh S., Khuri, Fadlo R., Curran, Walter J., Deng, Xingming

“…The BH4 domain of Bcl2 is required for its antiapoptotic function, thus constituting a promising anticancer target. We identified a small-molecule Bcl2-BH4…”
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Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck by Bonner, James A, Harari, Paul M, Giralt, Jordi, Azarnia, Nozar, Shin, Dong M, Cohen, Roger B, Jones, Christopher U, Sur, Ranjan, Raben, David, Jassem, Jacek, Ove, Roger, Kies, Merrill S, Baselga, Jose, Youssoufian, Hagop, Amellal, Nadia, Rowinsky, Eric K, Ang, K. Kian

“…Treatment of advanced locoregional head and neck cancer with high-dose radiotherapy plus cetuximab was superior to radiotherapy alone in improving local…”
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Parenteral Bevacizumab for the Treatment of Severe Respiratory Papillomatosis in an Adult Population by Tkaczuk, Andrew, Trivedi, Sumita, Mody, Mayur D., Steuer, Conor E., Shin, Dong M., Klein, Adam M., Saba, Nabil F.

“…Objectives/Hypothesis Recurrent respiratory papillomatosis (RRP) is a rare, potentially life‐threatening, disease that impacts the voice, breathing, and…”
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RRM2 Regulates Bcl-2 in Head and Neck and Lung Cancers: A Potential Target for Cancer Therapy by MOHAMMAD AMINUR RAHMAN, RUHUL AMIN, A. R. M, SHIN, Dong M, DONGSHENG WANG, KOENIG, Lydia, NANNAPANENI, Sreenivas, ZHENGJIA CHEN, ZHIBO WANG, SICA, Gabriel, XINGMING DENG, CHEN, Zhuo

“…Ribonucleotide reductase subunit M2 (RRM2) plays an active role in tumor progression. Recently, we reported that depletion of RRM2 by systemic delivery of a…”
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Efficacy of Systemic Bevacizumab for Recurrent Respiratory Papillomatosis with Pulmonary Involvement by So, Raymond J., Hidalgo Lopez, Julio C., Ballestas, Samir A., Klein, Adam M., Steuer, Conor, Shin, Dong M., Abousaud, Marin, Teng, Yong, Saba, Nabil F., Tkaczuk, Andrew T., Schaefer, Eric S., Seiwert, Tanguy Y., McClellan, Kim, Best, Simon R.

“…Objectives Pulmonary papillomatosis is a rare but severe manifestation of recurrent respiratory papillomatosis (RRP). Efficacy data of systemic bevacizumab for…”
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