Search Results - "Shimomura, Morito"

Minimal lactazole scaffold for in vitro thiopeptide bioengineering by Vinogradov, Alexander A., Shimomura, Morito, Goto, Yuki, Ozaki, Taro, Asamizu, Shumpei, Sugai, Yoshinori, Suga, Hiroaki, Onaka, Hiroyasu

“…Lactazole A is a cryptic thiopeptide from Streptomyces lactacystinaeus , encoded by a compact 9.8 kb biosynthetic gene cluster. Here, we establish a platform…”
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Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo by Ozaki, Taro, Yamashita, Kona, Goto, Yuki, Shimomura, Morito, Hayashi, Shohei, Asamizu, Shumpei, Sugai, Yoshinori, Ikeda, Haruo, Suga, Hiroaki, Onaka, Hiroyasu

“…Goadsporin (GS) is a member of ribosomally synthesized and post-translationally modified peptides (RiPPs), containing an N-terminal acetyl moiety, six azoles…”
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Promiscuous Enzymes Cooperate at the Substrate Level En Route to Lactazole A by Vinogradov, Alexander A, Shimomura, Morito, Kano, Naokazu, Goto, Yuki, Onaka, Hiroyasu, Suga, Hiroaki

“…Enzymes involved in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) often have relaxed specificity profiles and…”
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