Search Results - "Shimomura, Kyoichi"

New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action by Nakajima, H, Hori, Y, Terano, H, Okuhara, M, Manda, T, Matsumoto, S, Shimomura, K

“…FR901463, FR901464 and FR901465, novel antitumor substances, were isolated from the fermentation broth of Pseudomonas sp. No. 2663. Their antitumor activities…”
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FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice by Ueda, H, Manda, T, Matsumoto, S, Mukumoto, S, Nishigaki, F, Kawamura, I, Shimomura, K

“…The antitumor activities of FR901228, (E)-(1S,4S,10S,21R)-7-[(Z)- ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-…”
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Combined blockade of 5-HT3- and 5-HT4-serotonin receptors inhibits colonic functions in conscious rats and mice by Nagakura, Y, Kontoh, A, Tokita, K, Tomoi, M, Shimomura, K, Kadowaki, M

“…We have already reported that 5-hydroxytryptamine3 (5-HT3) receptor antagonists failed to modify 5-HT-accelerated colonic transit in conscious rats, but the…”
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Difference between Normal and WHHL Rabbits in Susceptibility to the Adrenal Toxicity of an Acyl-CoA:Cholesterol Acyltransferase Inhibitor, FR145237 by Matsuo, Masahiko, Hashimoto, Masaharu, Suzuki, Jyunya, Iwanami, Kohki, Tomoi, Masaaki, Shimomura, Kyoichi

“…The adrenal toxicity of an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, FR145237, was investigated using Japanese White (normal) and low density…”
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Anti‐cachectic Effect of FK317, a Novel Anti‐cancer Agent, in Colon26 and LX‐1 Models in Mice by Naoe, Yoshinori, Kawamura, Ikuo, Inami, Masamichi, Matsumoto, Sanae, Nishigaki, Fusako, Tsujimoto, Susumu, Manda, Toshitaka, Shimomura, Kyoichi

“…The effects of FK317 (11‐acetyl‐8‐carbamoyloxymethyl‐4‐formyl‐6‐methoxy‐14‐oxa‐1,11‐diazatetra‐cyclo[7.4.1.02,7.010,2]tetradeca‐2,4,6‐trien‐9‐yl acetate), a…”
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FK317, a Novel Substituted Dihydrobenzoxazine, Exhibits Potent Antitumor Activity against Human Tumor Xenografts in Nude Mice by Naoe, Yoshinori, Inami, Masamichi, Matsumoto, Sanae, Takagaki, Shoji, Fujiwara, Tomoichi, Yamazaki, Sachiko, Kawamura, Ikuo, Nishigaki, Fusako, Tsujimoto, Susumu, Manda, Toshitaka, Shimomura, Kyoichi

“…The antitumor effects of FK317, a novel substituted dihydrobenzoxazine, were evaluated using human tumor xenografts (small cell lung cancer, non‐small cell…”
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Different Effects of FK317 on Multidrug‐resistant Tumor in vivo and in vitro by Naoe, Yoshinori, Inami, Masamichi, Takagaki, Shoji, Matsumoto, Sanae, Kawamura, Ikuo, Nishigaki, Fusako, Tsujimoto, Susumu, Manda, Toshitaka, Shimomura, Kyoichi

“…FK317, a novel substituted dihydrobenzoxazine, was examined for antitumor effects on multidrug‐resistant (MDR) tumor cells in vitro and in vivo. In nude mice,…”
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Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall by Matsuo, Masahiko, Ito, Futoshi, Konto, Akiko, Aketa, Miho, Tomoi, Masaaki, Shimomura, Kyoichi

“…The hypocholesterolemic and antiatherosclerotic activities of FR145237, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, were evaluated in…”
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High‐level Production, Chemical Modification and Site‐directed Mutagenesis of a Cephalosporin C Acylase from Pseudomonas Strain N176 by Ishii, Yoshinori, Saito, Yoshimasa, Fujimura, Takao, Sasaki, Hitoshi, Noguchi, Yuji, Yamada, Hisashi, Niwa, Mineo, Shimomura, Kyoichi

“…A cephalosporin acylase from Pseudomonas strain N176 hydrolyses both 7‐β‐(4‐carboxybutanamido)‐cephalosporanic acid (glutarylcephalosporanic acid) and…”
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Immunosuppressive activity of a microbial product by Hatanaka, H, Shimomura, K

“…Microbial products have amazing diversity and complexity in their chemical structures as well as in their biological activities. The successful discovery and…”
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A new antitumor antibiotic, FR-900482. IV. Hematological toxicity in mice by Hirai, O, Shimomura, K, Mizota, T, Matsumoto, S, Mori, J, Kikuchi, H

“…The new antibiotic FR-900482 (4-formyl-6,9-dihydroxy-14-oxa-1,11-diazatetracyclo-[7.4.1.02,7. O10,12]tetradeca-2,4,6-triene-8-ylmethyl carbamate) possesses an…”
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A new antitumor antibiotic, FR-900482: V. Interstrand DNA-DNA cross-links in L1210 cells by Masuda, K, Nakamura, T, Shimomura, K, Shibata, T, Terano, H, Kohsaka, M

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A new aromatase inhibitor, FR901537. II. Pharmacological and antitumor effects by Oohata, N, Kawamura, I, Lacey, E, Nishigaki, F, Matsumoto, S, Tsujimoto, S, Naoe, Y, Manda, T, Shimomura, K

“…The pharmacological and antitumor effects of FR901537, a new aromatase inhibitor, isolated from Bacillus sp. No. 3072, were studied. Treatment for four…”
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The Induction of Interleukin-6 (IL-6) and Colony-Stimulating Factors (CSFs) by FK565 and Its Thrombopoietic Activity Following in Vivo Administration by MAEDA, Masahiro, SUZUKI, Shingo, OHTSUKA, Kazuyuki, SATOH, Susumu, NISHIGAKI, Fusako, SHIMOMURA, Kyoichi, IMAI, Yuko, NIWA, Mineo, KOHSAKA, Masanobu

“…The induction of macrophage colony-stimulating factor (M-CSF) in monkey plasma following administration of FK 565 was observed within 2 h of injection peaked…”
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Bromine Residue at Hydrophilic Region Influences Biological Activity of Aplysiatoxin, a Tumor Promoter by Shimomura, Kyoichi, Mullinix, Mary G., Kakunaga, Takeo, Fujiki, Hirota, Sugimura, Takashi

“…Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence…”
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A new antitumor antibiotic, FR900840. III. Antitumor activity against experimental tumors by Nishimura, M, Nakada, H, Kawamura, I, Mizota, T, Shimomura, K, Nakahara, K, Goto, T, Yamaguchi, I, Okuhara, M

“…FR900840 [2S)-2-amino-2-carboxyethyl (3R)-2-diazo-3-hydroxybutyrate), a new antibiotic with antitumor activity was isolated from the fermentation broth of…”
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Effects of a novel orally-active antiallergic drug, quinotolast (FK021), on airway clearance by Imai, T, Kai, H, Isohama, Y, Takahama, K, Miyata, T, Hiroi, J, Shimomura, K, Kohsaka, M

“…The effects of a novel antiallergic drug, quinotolast (FK021, sodium 5-(4-oxo-1-phenoxy-4H-quinolizine-3-carboxamido) tetrazolate monohydrate), on airway…”
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Specific Metabolic Activation of FK973, a New Antitumor Antibiotic, in L1210 Leukemia Cells by MASUDA, Kikuo, NAKAMURA, Takaaki, SHIMOMURA, Kyoichi

“…FK973 (11-acetyl-8-carbamoyloxymethyl-4-formyM 4-oxa-1, 11-diazatetracyclo[7.4.1.02,7010,12]tetradeca-2,4,6-trien-6,9-diyl diacetate), a new substituted…”
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Implication of Sensory Neurons in the Diverse Mechanisms of Adaptive Cytoprotection in the Rat Stomach by Hatakeyama, Yoshifumi, Tomoi, Masaaki, Ohtsuka, Minoru, Shimomura, Kyoichi

“…Adaptive cytoprotection is mediated by diverse mediators and mechanisms. We investigated the implication of capsaicin-sensitive afferent neurons in the…”
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Cloning of genes coding for L-sorbose and L-sorbosone dehydrogenases from Gluconobacter oxydans and microbial production of 2-keto-L-gulonate, a precursor of L-ascorbic acid, in a recombinant G. oxydans strain by SAITO, Y, ISHII, Y, HOSODA, J, SHIMOMURA, K, HAYASHI, H, IMAO, Y, AKASHI, T, YOSHIKAWA, K, NOGUCHI, Y, SOEDA, S, YOSHIDA, M, NIWA, M

“…Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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