Search Results - "Shimomura, Kazunori"

Clinical Safety and Effectiveness of Adipose-Derived Stromal Cell vs Stromal Vascular Fraction Injection for Treatment of Knee Osteoarthritis: 2-Year Results of Parallel Single-Arm Trials by Yokota, Naomasa, Lyman, Stephen, Hanai, Hiroto, Shimomura, Kazunori, Ando, Wataru, Nakamura, Norimasa

“…Background: There are currently no disease-modifying treatments available for knee osteoarthritis (OA), although cultured adipose-derived stromal cells (ASCs)…”
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Comparative Clinical Outcomes After Intra-articular Injection With Adipose-Derived Cultured Stem Cells or Noncultured Stromal Vascular Fraction for the Treatment of Knee Osteoarthritis by Yokota, Naomasa, Hattori, Mari, Ohtsuru, Tadahiko, Otsuji, Masaki, Lyman, Stephen, Shimomura, Kazunori, Nakamura, Norimasa

“…Background: Intra-articular injection of adipose-derived stem cells (ASCs) has shown promise for improving symptoms and cartilage quality in the treatment of…”
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Region-Specific Effect of the Decellularized Meniscus Extracellular Matrix on Mesenchymal Stem Cell–Based Meniscus Tissue Engineering by Shimomura, Kazunori, Rothrauff, Benjamin B., Tuan, Rocky S.

“…Background: The meniscus is the most commonly injured knee structure, and surgical repair is often ineffective. Tissue engineering–based repair or regeneration…”
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First-in-Human Pilot Study of Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stem Cells for Repair of Knee Chondral Lesions by Shimomura, Kazunori, Yasui, Yukihiko, Koizumi, Kota, Chijimatsu, Ryota, Hart, David A., Yonetani, Yasukazu, Ando, Wataru, Nishii, Takashi, Kanamoto, Takashi, Horibe, Shuji, Yoshikawa, Hideki, Nakamura, Norimasa, Sakaue, Morito, Sugita, Norihiko, Moriguchi, Yu

“…Background: Articular cartilage has limited healing capacity, owing in part to poor vascularity and innervation. Once injured, it cannot be repaired, typically…”
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Osteochondral Injury, Management and Tissue Engineering Approaches by Jacob, George, Shimomura, Kazunori, Nakamura, Norimasa

“…Osteochondral lesions (OL) are a common clinical problem for orthopedic surgeons worldwide and are associated with multiple clinical scenarios ranging from…”
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Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation by Morii, Yusuke, Tsubaki, Masanobu, Takeda, Tomoya, Otubo, Rie, Seki, Shiori, Yamatomo, Yuta, Imano, Motohiro, Satou, Takao, Shimomura, Kazunori, Nishida, Shozo

“…Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutation in colon cancer contributes to the poor prognosis of the disease and…”
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The Meniscus Tear: A Review of Stem Cell Therapies by Jacob, George, Shimomura, Kazunori, Krych, Aaron J, Nakamura, Norimasa

“…Meniscal injuries have posed a challenging problem for many years, especially considering that historically the meniscus was considered to be a structure with…”
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Freeze-dried noncoagulating platelet-derived factor concentrate is a safe and effective treatment for early knee osteoarthritis by Ohtsuru, Tadahiko, Otsuji, Masaki, Nakanishi, Jun, Nakamura, Norimasa, Lyman, Stephen, Hanai, Hiroto, Shimomura, Kazunori, Ando, Wataru

“…Purpose While a wide variety of platelet-rich plasma (PRP) solutions has been developed, innovation continues. In this case, the freeze-dried platelet factor…”
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Comparative Clinical Outcomes After Intra-articular Injection With Adipose-Derived Cultured Stem Cells or Noncultured Stromal Vascular Fraction for the Treatment of Knee Osteoarthritis: Response by Nakamura, Norimasa, Yokota, Naomasa, Hattori, Mari, Ohtsuru, Tadahiko, Otsuji, Masaki, Lyman, Stephen, Shimomura, Kazunori

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Overactivation of Akt Contributes to MEK Inhibitor Primary and Acquired Resistance in Colorectal Cancer Cells by Tsubaki, Masanobu, Takeda, Tomoya, Noguchi, Masaki, Jinushi, Minami, Seki, Shiori, Morii, Yuusuke, Shimomura, Kazunori, Imano, Motohiro, Satou, Takao, Nishida, Shozo

“…RAS and BRAF-mutated colorectal cancers are associated with resistance to chemotherapy and poor prognosis, highlighting the need for new therapeutic…”
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Utilization of orthobiologic augmentation for meniscal repairs: current concepts and future perspectives by Shimomura, Kazunori, Jacob, George, Hanai, Hiroto, Nakamura, Norimasa

“…Meniscal tissue is a complex structure and performs a vital role in the normal biomechanical functioning of the knee joint. Unfortunately, meniscal tissue…”
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Current hip cartilage regeneration/repair modalities: a scoping review of biologics and surgery by Hevesi, Mario, Jacob, George, Shimomura, Kazunori, Ando, Wataru, Nakamura, Norimasa, Krych, Aaron J.

“…Purpose The rapidly growing and emerging nature of biologics have made indications for regenerative and reparative hip therapies ever changing, with at times…”
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Repair of meniscal lesions using a scaffold-free tissue-engineered construct derived from allogenic synovial MSCs in a miniature swine model by Moriguchi, Yu, Tateishi, Kosuke, Ando, Wataru, Shimomura, Kazunori, Yonetani, Yasukazu, Tanaka, Yoshinari, Kita, Keisuke, Hart, David A, Gobbi, Alberto, Shino, Konsei, Yoshikawa, Hideki, Nakamura, Norimasa

“…Abstract The menisci of the knee are fibro-cartilaginous tissues and play important roles in the joint, and the loss of the meniscus predisposes the knee to…”
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Time-Dependent Recovery of Human Synovial Membrane Mesenchymal Stem Cell Function After High-Dose Steroid Therapy: Case Report and Laboratory Study by Yasui, Yukihiko, Hart, David A., Sugita, Norihiko, Chijimatsu, Ryota, Koizumi, Kota, Ando, Wataru, Moriguchi, Yu, Shimomura, Kazunori, Myoui, Akira, Yoshikawa, Hideki, Nakamura, Norimasa

“…Background: The use of mesenchymal stem cells from various tissue sources to repair injured tissues has been explored over the past decade in large preclinical…”
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The influence of skeletal maturity on allogenic synovial mesenchymal stem cell-based repair of cartilage in a large animal model by Shimomura, Kazunori, Ando, Wataru, Tateishi, Kosuke, Nansai, Ryosuke, Fujie, Hiromichi, Hart, David A, Kohda, Hideyuki, Kita, Keisuke, Kanamoto, Takashi, Mae, Tatsuo, Nakata, Ken, Shino, Konsei, Yoshikawa, Hideki, Nakamura, Norimasa

“…Abstract One of the potential factors that may affect the results of mesenchymal stem cell (MSC)-based therapy is the age of donors and recipients. However,…”
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The HGF/Met/NF-κB Pathway Regulates RANKL Expression in Osteoblasts and Bone Marrow Stromal Cells by Tsubaki, Masanobu, Seki, Shiori, Takeda, Tomoya, Chihara, Akiko, Arai, Yuuko, Morii, Yuusuke, Imano, Motohiro, Satou, Takao, Shimomura, Kazunori, Nishida, Shozo

“…Multiple myeloma (MM)-induced bone disease occurs through hyperactivation of osteoclasts by several factors secreted by MM cells. MM cell-secreted factors…”
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A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinic by Shimomura, Kazunori, Ando, Wataru, Hart, David A., Nakamura, Norimasa

“…Treatments for articular cartilage injuries are still challenging, due in part to its avascular and aneural surroundings. Since the first report of autologous…”
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Meniscal repair and regeneration: Current strategies and future perspectives by Shimomura, Kazunori, Hamamoto, Shuichi, Hart, David A, Yoshikawa, Hideki, Nakamura, Norimasa

“…Abstract The management of meniscal injuries remains difficult and challenging. Although several clinical options exist for the treatment of such injuries,…”
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Vibration acceleration promotes endochondral formation during fracture healing through cellular chondrogenic differentiation by Yokoi, Hiroyuki, Take, Yasuhiro, Uchida, Ryohei, Magome, Takuya, Shimomura, Kazunori, Mae, Tatsuo, Okamoto, Tomoko, Hanai, Tatsuhiro, Chong, Yang, Sato, Seira, Hikida, Minami, Nakata, Ken

“…Vibration acceleration through whole body vibration has been reported to promote fracture healing. However, the mechanism responsible for this effect remains…”
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Osteochondral repair using a scaffold-free tissue-engineered construct derived from synovial mesenchymal stem cells and a hydroxyapatite-based artificial bone by Shimomura, Kazunori, Moriguchi, Yu, Ando, Wataru, Nansai, Ryosuke, Fujie, Hiromichi, Hart, David A, Gobbi, Alberto, Kita, Keisuke, Horibe, Shuji, Shino, Konsei, Yoshikawa, Hideki, Nakamura, Norimasa

“…For an ideal osteochondral repair, it is important to facilitate zonal restoration of the subchondral bone and the cartilage, layer by layer. Specifically,…”
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