Search Results - "Shimizu, Jacqueline Farinha"

Plant-derived antivirals against hepatitis c virus infection by Jardim, Ana Carolina Gomes, Shimizu, Jacqueline Farinha, Rahal, Paula, Harris, Mark

“…Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected…”
Get full text

Chikungunya virus entry is strongly inhibited by phospholipase A2 isolated from the venom of Crotalus durissus terrificus by Santos, Igor Andrade, Shimizu, Jacqueline Farinha, de Oliveira, Débora Moraes, Martins, Daniel Oliveira Silva, Cardoso-Sousa, Léia, Cintra, Adélia Cristina Oliveira, Aquino, Victor Hugo, Sampaio, Suely Vilela, Nicolau-Junior, Nilson, Sabino-Silva, Robinson, Merits, Andres, Harris, Mark, Jardim, Ana Carolina Gomes

“…Chikungunya virus (CHIKV) is the etiologic agent of Chikungunya fever, a globally spreading mosquito-borne disease. There is no approved antiviral or vaccine…”
Get full text

Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry by Shimizu, Jacqueline Farinha, Lima, Caroline Sprengel, Pereira, Carina Machado, Bittar, Cintia, Batista, Mariana Nogueira, Nazaré, Ana Carolina, Polaquini, Carlos Roberto, Zothner, Carsten, Harris, Mark, Rahal, Paula, Regasini, Luis Octávio, Jardim, Ana Carolina Gomes

“…Hepatitis C virus (HCV) is one of the leading causes of liver diseases and transplantation worldwide. The current available therapy for HCV infection is based…”
Get full text

Antiviral Activity of Quercetin Hydrate against Zika Virus by Saivish, Marielena Vogel, Menezes, Gabriela de Lima, da Silva, Roosevelt Alves, Fontoura, Marina Alves, Shimizu, Jacqueline Farinha, da Silva, Gislaine Celestino Dutra, Teixeira, Igor da Silva, Mistrão, Natalia Franco Bueno, Hernandes, Victor Miranda, Rahal, Paula, Sacchetto, Lívia, Pacca, Carolina Colombelli, Marques, Rafael Elias, Nogueira, Maurício Lacerda

“…Zika virus (ZIKV) has re-emerged in recent decades, leading to outbreaks of Zika fever in Africa, Asia, and Central and South America. Despite its drastic…”
Get full text

Phenotypical Screening of an MMV Open Box Library and Identification of Compounds with Antiviral Activity against St. Louis Encephalitis Virus by Sotorilli, Giuliana Eboli, Gravina, Humberto Doriguetto, de Carvalho, Ana Carolina, Shimizu, Jacqueline Farinha, Fontoura, Marina Alves, Melo-Hanchuk, Talita Diniz, Cordeiro, Artur Torres, Marques, Rafael Elias

“…St. Louis encephalitis virus (SLEV) is a neglected mosquito-borne Flavivirus that may cause severe neurological disease in humans and other animals. There are…”
Get full text

Nanopore sequencing from extraction-free direct PCR of dried serum spots for portable hepatitis B virus drug-resistance typing by Astbury, Stuart, Costa Nunes Soares, Marcia Maria, Peprah, Emmanuel, King, Barnabas, Jardim, Ana Carolina Gomes, Shimizu, Jacqueline Farinha, Jalal, Paywast, Saeed, Chiman H., Sabeer, Furat T., Irving, William L., Tarr, Alexander W., McClure, C. Patrick

“…•Screening for resistance associated substitutions in hepatitis B virus genomes is possible from dried serum spots (DSS).•Longer regions sampled from…”
Get full text

Multiple effects of toxins isolated from Crotalus durissus terrificus on the hepatitis C virus life cycle by Shimizu, Jacqueline Farinha, Pereira, Carina Machado, Bittar, Cintia, Batista, Mariana Nogueira, Campos, Guilherme Rodrigues Fernandes, da Silva, Suely, Cintra, Adélia Cristina Oliveira, Zothner, Carsten, Harris, Mark, Sampaio, Suely Vilela, Aquino, Victor Hugo, Rahal, Paula, Jardim, Ana Carolina Gomes

“…Hepatitis C virus (HCV) is one of the main causes of liver disease and transplantation worldwide. Current therapy is expensive, presents additional side…”
Get full text

A diarylamine derived from anthranilic acid inhibits ZIKV replication by Silva, Suely, Shimizu, Jacqueline Farinha, Oliveira, Débora Moraes de, Assis, Leticia Ribeiro de, Bittar, Cintia, Mottin, Melina, Sousa, Bruna Katiele de Paula, Mesquita, Nathalya Cristina de Moraes Roso, Regasini, Luis Octávio, Rahal, Paula, Oliva, Glaucius, Perryman, Alexander Luke, Ekins, Sean, Andrade, Carolina Horta, Goulart, Luiz Ricardo, Sabino-Silva, Robinson, Merits, Andres, Harris, Mark, Jardim, Ana Carolina Gomes

“…Zika virus (ZIKV) is a mosquito-transmitted Flavivirus, originally identified in Uganda in 1947 and recently associated with a large outbreak in South America…”
Get full text

Salivary Detection of Zika Virus Infection Using ATR-FTIR Spectroscopy Coupled with Machine Learning Algorithms and Univariate Analysis: A Proof-of-Concept Animal Study by Oliveira, Stephanie Wutke, Cardoso-Sousa, Leia, Georjutti, Renata Pereira, Shimizu, Jacqueline Farinha, Silva, Suely, Caixeta, Douglas Carvalho, Guevara-Vega, Marco, Cunha, Thúlio Marquez, Carneiro, Murillo Guimarães, Goulart, Luiz Ricardo, Jardim, Ana Carolina Gomes, Sabino-Silva, Robinson

“…Zika virus (ZIKV) diagnosis is currently performed through an invasive, painful, and costly procedure using molecular biology. Consequently, the search for a…”
Get full text

Identification of Compounds With Antiviral Activity Against SARS-CoV-2 in the MMV Pathogen Box Using a Phenotypic High-Throughput Screening Assay by Coimbra, Laís D., Borin, Alexandre, Fontoura, Marina, Gravina, Humberto D., Nagai, Alice, Shimizu, Jacqueline Farinha, Bispo-dos-Santos, Karina, Granja, Fabiana, Oliveira, Paulo S. L., Franchini, Kleber G., Samby, Kirandeep, Bruder, Marjorie, Proença-Módena, José Luiz, Trivella, Daniela B. B., Smetana, Juliana H. C., Cordeiro, Artur T., Marques, Rafael Elias

“…Until December 2021, the COVID-19 pandemic has caused more than 5.5 million deaths. Vaccines are being deployed worldwide to mitigate severe disease and death,…”
Get full text

Current challenges in the discovery of treatments against Mayaro fever by Marques, Rafael Elias, Shimizu, Jacqueline Farinha, Nogueira, Maurício Lacerda, Vasilakis, Nikos

“…Mayaro fever is an emerging viral disease that manifests as an acute febrile illness. The disease is self-limiting, however joint pain can persist for months…”
Get more information

Effect of proteins isolated from Brazilian snakes on enterovirus A71 replication cycle: An approach against hand, foot and mouth disease by Shimizu, Jacqueline Farinha, Feferbaum-Leite, Shiraz, Santos, Igor Andrade, Martins, Daniel Oliveira Silva, Kingston, Natalie J., Shegdar, Mona, Zothner, Carsten, Sampaio, Suely Vilela, Harris, Mark, Stonehouse, Nicola J., Jardim, Ana Carolina Gomes

“…Enterovirus A71 (EVA71) belongs to the Picornaviridae family and is the main etiological agent of hand, foot, and mouth disease (HFMD). There is no approved…”
Get full text

Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches? by Shimizu, Jacqueline Farinha, Martins, Daniel Oliveira Silva, McPhillie, Martin J., Roberts, Grace C., Zothner, Carsten, Merits, Andres, Harris, Mark, Jardim, Ana Carolina Gomes

“…•Virtual screening identifies molecules that binding to ADP-ribose site of CHIKV•Two selected compounds inhibited CHIKV replication in vitro•Compounds are…”
Get full text

Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptor by Mercaldi, Gustavo Fernando, Bezerra, Eduardo Henrique Salviano, Batista, Fernanda Aparecida Heleno, Tonoli, Celisa Caldana Costa, Soprano, Adriana Santos, Shimizu, Jacqueline Farinha, Nagai, Alice, da Silva, Jaqueline Cristina, Filho, Helder Veras Ribeiro, do Nascimento Faria, Jéssica, da Cunha, Marcos Guilherme, Zeri, Ana Carolina Mattos, Nascimento, Andrey Fabricio Ziem, Proenca-Modena, José Luiz, Bajgelman, Marcio Chaim, Rocco, Silvana Aparecida, Lopes-de-Oliveira, Paulo Sérgio, Cordeiro, Artur Torres, Bruder, Marjorie, Marques, Rafael Elias, Sforça, Mauricio Luis, Franchini, Kleber Gomes, Benedetti, Celso Eduardo, Figueira, Ana Carolina Migliorini, Trivella, Daniela Barretto Barbosa

“…The nucleocapsid (N) protein plays critical roles in coronavirus genome transcription and packaging, representing a key target for the development of novel…”
Get full text

UV 254 nm is more efficient than UV 222 nm in inactivating SARS-CoV-2 present in human saliva by Sesti-Costa, Renata, Negrão, Cyro von Zuben, Shimizu, Jacqueline Farinha, Nagai, Alice, Tavares, Renata Spagolla Napoleão, Adamoski, Douglas, Costa, Wanderley, Fontoura, Marina Alves, da Silva, Thiago Jasso, de Barros, Adriano, Girasole, Alessandra, de Carvalho, Murilo, Teixeira, Veronica de Carvalho, Ambrosio, Andre Luis Berteli, Granja, Fabiana, Proença-Módena, José Luiz, Marques, Rafael Elias, Dias, Sandra Martha Gomes

“…•We tested 222 and 254 nm irradiation for inactivation of SARS-CoV-2.•254 nm was ∼200-fold more effective than 222 nm in saliva.•A 10.4 mJ/cm2 UV 254 nm dose…”
Get full text

Hepatitis C virus in vitro replication is efficiently inhibited by acridone Fac4 by Campos, Guilherme Rodrigues Fernandes, Bittar, Cíntia, Jardim, Ana Carolina Gomes, Shimizu, Jacqueline Farinha, Batista, Mariana Nogueira, Paganini, Eder Ramos, Assis, Letícia Ribeiro de, Bartlett, Christopher, Harris, Mark, Bolzani, Vanderlan da Silva, Regasini, Luis Octavio, Rahal, Paula

“…Hepatitis C virus (HCV) affects about 170 million people worldwide. The current treatment has a high cost and variable response rates according to the virus…”
Get full text

Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds by Borin, Alexandre, Coimbra, Laís D., Bispo-dos-Santos, Karina, Naciuk, Fabrício F., Fontoura, Marina, Simeoni, Camila L., Gomes, Giovanni F., Amorim, Mariene R., Gravina, Humberto D., Shimizu, Jacqueline Farinha, Passos, Amanda S. C., de Oliveira, Isadora M., de Carvalho, Ana Carolina, Cardoso, Alisson Campos, Parise, Pierina L., Toledo-Teixeira, Daniel A., Sotorilli, Giuliana E., Persinoti, Gabriela F., Claro, Ingra Morales, Sabino, Ester C., Alborghetti, Marcos R., Rocco, Silvana A., Franchini, Kleber G., de Souza, William M., Oliveira, Paulo S. L., Cunha, Thiago M., Granja, Fabiana, Proença-Módena, José Luiz, Trivella, Daniela B.B., Bruder, Marjorie, Cordeiro, Artur T., Marques, Rafael Elias

“…The ongoing COVID-19 pandemic caused a significant loss of human lives and a worldwide decline in quality of life. Treatment of COVID-19 patients is…”
Get full text

Simultaneous determination of HCV genotype and NS5B resistance associated substitutions using dried serum spots from São Paulo state, Brazil by Adeboyejo, Kazeem, Grosche, Victória Riquena, José, Diego Pandeló, Ferreira, Giulia Magalhães, Shimizu, Jacqueline Farinha, King, Barnabas J, Tarr, Alexander W, Soares, Márcia Maria Costa Nunes, Ball, Jonathan K, McClure, C Patrick, Jardim, Ana Carolina Gomes

“…Hepatitis C virus (HCV) is responsible for more than 180 million infections worldwide, and about 80 % of infections are reported in Low and Middle-income…”
Get full text