Search Results - "Shimberg, Geoffrey"

Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming by Suryo Rahmanto, Yohan, Shen, Wenjing, Shi, Xu, Chen, Xi, Yu, Yu, Yu, Zheng-Cheng, Miyamoto, Tsutomu, Lee, Meng-Horng, Singh, Vivek, Asaka, Ryoichi, Shimberg, Geoffrey, Vitolo, Michele I., Martin, Stuart S., Wirtz, Denis, Drapkin, Ronny, Xuan, Jianhua, Wang, Tian-Li, Shih, Ie-Ming

“…Somatic inactivating mutations of ARID1A , a SWI/SNF chromatin remodeling gene, are prevalent in human endometrium-related malignancies. To elucidate the…”
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Cu(I) Disrupts the Structure and Function of the Nonclassical Zinc Finger Protein Tristetraprolin (TTP) by Shimberg, Geoffrey D, Ok, Kiwon, Neu, Heather M, Splan, Kathryn E, Michel, Sarah L. J

“…Tristetraprolin (TTP) is a nonclassical zinc finger (ZF) protein that plays a key role in regulating inflammatory response. TTP regulates cytokines at the mRNA…”
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An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans by Andrews, Sarah F, Cominsky, Lauren Y, Shimberg, Geoffrey D, Gillespie, Rebecca A, Gorman, Jason, Raab, Julie E, Brand, Joshua, Creanga, Adrian, Gajjala, Suprabhath R, Narpala, Sandeep, Cheung, Crystal S F, Harris, Darcy R, Zhou, Tongqing, Gordon, Ingelise, Holman, LaSonji, Mendoza, Floreliz, Houser, Katherine V, Chen, Grace L, Mascola, John R, Graham, Barney S, Kwong, Peter D, Widge, Alicia, Dropulic, Lesia K, Ledgerwood, Julie E, Kanekiyo, Masaru, McDermott, Adrian B

“…Current yearly seasonal influenza vaccines primarily induce an antibody response directed against the immunodominant but continually diversifying hemagglutinin…”
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Direct Zinc Finger Protein Persulfidation by H2S Is Facilitated by Zn2 by Lange, Mike, Ok, Kiwon, Shimberg, Geoffrey D., Bursac, Biljana, Markó, Lajos, Ivanović‐Burmazović, Ivana, Michel, Sarah L. J., Filipovic, Milos R.

“…H2S is a gaseous signaling molecule that modifies cysteine residues in proteins to form persulfides (P‐SSH). One family of proteins modified by H2S are zinc…”
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Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe–2S cluster by Shimberg, Geoffrey D., Michalek, Jamie L., Oluyadi, Abdulafeez A., Rodrigues, Andria V., Zucconi, Beth E., Neu, Heather M., Ghosh, Shanchari, Sureschandra, Kanisha, Wilson, Gerald M., Stemmler, Timothy L., Michel, Sarah L. J.

“…Cleavage and polyadenylation specificity factor 30 (CPSF30) is a key protein involved in pre-mRNA processing. CPSF30 contains five Cys₃His domains (annotated…”
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Understanding RNA Binding by the Nonclassical Zinc Finger Protein CPSF30, a Key Factor in Polyadenylation during Pre-mRNA Processing by Pritts, Jordan D, Oluyadi, Abdulafeez A, Huang, Weiliang, Shimberg, Geoffrey D, Kane, Maureen A, Wilks, Angela, Michel, Sarah L. J

“…Cleavage and polyadenylation specificity factor 30 (CPSF30) is a zinc finger protein that regulates pre-mRNA processing. CPSF30 contains five CCCH domains and…”
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Direct Zinc Finger Protein Persulfidation by H 2 S Is Facilitated by Zn 2 by Lange, Mike, Ok, Kiwon, Shimberg, Geoffrey D, Bursac, Biljana, Markó, Lajos, Ivanović-Burmazović, Ivana, Michel, Sarah L J, Filipovic, Milos R

“…H S is a gaseous signaling molecule that modifies cysteine residues in proteins to form persulfides (P-SSH). One family of proteins modified by H S are zinc…”
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Development of small molecule inhibitors targeting PBX1 transcription signaling as a novel cancer therapeutic strategy by Shen, Yao-An, Jung, Jin, Shimberg, Geoffrey D., Hsu, Fang-Chi, Rahmanto, Yohan Suryo, Gaillard, Stephanie L., Hong, Jiaxin, Bosch, Jürgen, Shih, Ie-Ming, Chuang, Chi-Mu, Wang, Tian-Li

“…PBX1 is a transcription factor involved in diverse cellular functions including organ development, stem cell renewal, and tumorigenesis. PBX1 is localized at…”
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Design of a synthetic luminescent probe from a biomolecule binding domain: selective detection of AU-rich mRNA sequences by Raibaut, Laurent, Vasseur, William, Shimberg, Geoffrey D, Saint-Pierre, Christine, Ravanat, Jean-Luc, Michel, Sarah L J, Sénèque, Olivier

“…We report the design of a luminescent sensor based upon the zinc finger (ZF) protein TIS11d, that allows for the selective time-resolved detection of the…”
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Iron-Sulfur Clusters in Zinc Finger Proteins by Shimberg, Geoffrey D, Pritts, Jordan D, Michel, Sarah L J

“…Zinc finger (ZF) proteins are proteins that use zinc as a structural cofactor. The common feature among all ZFs is that they contain repeats of four cysteine…”
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Direct Zinc Finger Protein Persulfidation by H2S Is Facilitated by Zn2 by Lange, Mike, Ok, Kiwon, Shimberg, Geoffrey D., Bursac, Biljana, Markó, Lajos, Ivanović‐Burmazović, Ivana, Michel, Sarah L. J., Filipovic, Milos R.

“…H2S is a gaseous signaling molecule that modifies cysteine residues in proteins to form persulfides (P‐SSH). One family of proteins modified by H2S are zinc…”
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Understanding RNA binding by the non-classical Zinc Finger Protein CPSF30, a key factor in polyadenylation during pre-mRNA processing by Pritts, Jordan D., Oluyadi, Abdulafeez A., Huang, Weiliang, Shimberg, Geoffrey D., Kane, Maureen A., Wilks, Angela, Michel, Sarah L. J.

“…Cleavage and polyadenylation specificity factor 30 (CPSF30) is a zinc finger protein that regulates pre-mRNA processing. CPSF30 contains five CCCH and one CCHC…”
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CPSF30, a Novel Non-Classical Zinc Finger Protein that Utilizes Iron & Zinc Coordination for RNA Recognition by Shimberg, Geoffrey, Michalek, Jamie, Rodrigues, Andria, Stemmler, Timothy, Michel, Sarah

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Modifying Zinc Fingers: Targeting the Inflammatory Zinc Finger Protein, Tristetraprolin, with Exogenous Gold Complexes and Determining a Role for H2S in Modifying Trisetrapolin Endogenously by Ok, Kiwon, Li, Wenjing, Shimberg, Geoffrey D., Batelu, Sharon, Lange, Mike, Ivanovic-Burmazovic, Ivana, Stemmler, Dr. Timothy, Kane, Maureen A., Filipovic, Milos R., Michel, Sarah L.

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Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones by Lima, Noemia S., Musayev, Maryam, Johnston, Timothy S., Wagner, Danielle A., Henry, Amy R., Wang, Lingshu, Yang, Eun Sung, Zhang, Yi, Birungi, Kevina, Black, Walker P., O’Dell, Sijy, Schmidt, Stephen D., Moon, Damee, Lorang, Cynthia G., Zhao, Bingchun, Chen, Man, Boswell, Kristin L., Roberts-Torres, Jesmine, Davis, Rachel L., Peyton, Lowrey, Narpala, Sandeep R., O’Connell, Sarah, Serebryannyy, Leonid, Wang, Jennifer, Schrager, Alexander, Talana, Chloe Adrienna, Shimberg, Geoffrey, Leung, Kwanyee, Shi, Wei, Khashab, Rawan, Biber, Asaf, Zilberman, Tal, Rhein, Joshua, Vetter, Sara, Ahmed, Afeefa, Novik, Laura, Widge, Alicia, Gordon, Ingelise, Guech, Mercy, Teng, I-Ting, Phung, Emily, Ruckwardt, Tracy J., Pegu, Amarendra, Misasi, John, Doria-Rose, Nicole A., Gaudinski, Martin, Koup, Richard A., Kwong, Peter D., McDermott, Adrian B., Amit, Sharon, Schacker, Timothy W., Levy, Itzchak, Mascola, John R., Sullivan, Nancy J., Schramm, Chaim A., Douek, Daniel C.

“…An important consequence of infection with a SARS-CoV-2 variant is protective humoral immunity against other variants. However, the basis for such…”
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Design of a synthetic luminescent probe from a biomolecule binding domain: selective detection of AU-rich mRNA sequencesElectronic supplementary information (ESI) available: Details of synthetic procedures of LTISTb, recombinant expression of TTP-2D and spectroscopic characterization of LTISTb and its RNA-binding properties. See DOI: 10.1039/c6sc04086a by Raibaut, Laurent, Vasseur, William, Shimberg, Geoffrey D, Saint-Pierre, Christine, Ravanat, Jean-Luc, Michel, Sarah L. J, Sénèque, Olivier

“…We report the design of a luminescent sensor based upon the zinc finger (ZF) protein TIS11d, that allows for the selective time-resolved detection of the…”
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Design of a synthetic luminescent probe from a biomolecule binding domain: selective detection of AU-rich mRNA sequences† †Electronic supplementary information (ESI) available: Details of synthetic procedures of LTISTb, recombinant expression of TTP-2D and spectroscopic characterization of LTISTb and its RNA-binding properties. See DOI: 10.1039/c6sc04086a Click here for additional data file by Raibaut, Laurent, Vasseur, William, Shimberg, Geoffrey D., Saint-Pierre, Christine, Ravanat, Jean-Luc, Michel, Sarah L. J., Sénèque, Olivier

“…We report the design of a luminescent sensor based upon the zinc finger protein TIS11d, that allows for the selective time-resolved detection of the UUAUUUAUU…”
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A Tale of Two Zinc Fingers: Structure and Functional Studies of CCCH type Zinc Finger Proteins CPSF30 and TTP involved in RNA Regulation by Shimberg, Geoffrey D

“…CPSF30 and TTP are non-classical zinc finger proteins (ZFS) that contain domains with a CCCH motif. CPSF30 has 5 CCCH domains and TTP has 2 CCCH domains. Both…”
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Direct Zinc Finger Protein Persulfidation by H2 S Is Facilitated by Zn2 by Lange, Mike, Ok, Kiwon, Shimberg, Geoffrey D, Bursac, Biljana, Markó, Lajos, Ivanović-Burmazović, Ivana, Michel, Sarah L J, Filipovic, Milos R

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Direct Zinc Finger Protein Persulfidation by H 2 S Is Facilitated by Zn 2 by Lange, Mike, Ok, Kiwon, Shimberg, Geoffrey D., Bursac, Biljana, Markó, Lajos, Ivanović‐Burmazović, Ivana, Michel, Sarah L. J., Filipovic, Milos R.

“…H 2 S is a gaseous signaling molecule that modifies cysteine residues in proteins to form persulfides (P‐SSH). One family of proteins modified by H 2 S are…”
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