Search Results - "Shimazawa, M"

Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis by Takata, M, Tanaka, H, Kimura, M, Nagahara, Y, Tanaka, K, Kawasaki, K, Seto, M, Tsuruma, K, Shimazawa, M, Hara, H

“…Background and Purpose Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with no effective treatment. Fasudil hydrochloride (fasudil),…”
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Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia by Hyakkoku, K, Hamanaka, J, Tsuruma, K, Shimazawa, M, Tanaka, H, Uematsu, S, Akira, S, Inagaki, N, Nagai, H, Hara, H

“…Abstract Toll-like receptors (TLRs) are signaling receptors in the innate immune system that is a specific immunologic response to systemic bacterial…”
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Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia–reperfusion injury by Nakano, Y, Suzuki, Y, Takagi, T, Kitashoji, A, Ono, Y, Tsuruma, K, Yoshimura, S, Shimazawa, M, Iwama, T, Hara, H

“…Highlights • GPNMB expression is up-regulated after ischemia–reperfusion injury. • GPNMB significantly ameliorated infarct volume. • The protective mechanism…”
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A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice by Mishiro, K, Ishiguro, M, Suzuki, Y, Tsuruma, K, Shimazawa, M, Hara, H

“…Abstract Delayed activation of tissue plasminogen activator (tPA) can lead to the disruption of the blood–brain barrier (BBB), resulting in hemorrhagic…”
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Neuropeptide VGF-Derived Peptide LQEQ-19 has Neuroprotective Effects in an In Vitro Model of Amyotrophic Lateral Sclerosis by Noda, Y., Motoyama, S., Nakamura, S., Shimazawa, M., Hara, H.

“…Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease caused by the loss of upper and lower motor neurons resulting in muscle weakness and…”
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Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil by Oida, Y, Shimazawa, M, Imaizumi, K, Hara, H

“…Abstract Endoplasmic reticulum (ER) stress, which is caused by an accumulation of unfolded proteins in the ER lumen, is associated with stroke and with…”
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A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator by Ishiguro, M, Kawasaki, K, Suzuki, Y, Ishizuka, F, Mishiro, K, Egashira, Y, Ikegaki, I, Tsuruma, K, Shimazawa, M, Yoshimura, S, Iwama, T, Hara, H

“…Highlights ► Fasudil, a Rho kinase inhibitor, exerted neuroprotective effects against tPA-induced injury. ► Protective effects of fasudil were observed not…”
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Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil by Oida, Y, Izuta, H, Oyagi, A, Shimazawa, M, Kudo, T, Imaizumi, K, Hara, H

“…Abstract Endoplasmic reticulum (ER) stress, which is caused by the accumulation of unfolded proteins in the ER lumen, is associated with stroke and…”
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A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice by Koumura, A, Nonaka, Y, Hyakkoku, K, Oka, T, Shimazawa, M, Hozumi, I, Inuzuka, T, Hara, H

“…Abstract Cerebral ischemia induces Ca2+ influx into neuronal cells, and activates several proteases including calpains. Since calpains play important roles in…”
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Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice by Morimoto, N, Oida, Y, Shimazawa, M, Miura, M, Kudo, T, Imaizumi, K, Hara, H

“…Abstract The endoplasmic reticulum (ER) plays an important role in ischemic neuronal cell death. ER stress-related markers [immunoglobulin binding protein…”
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Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury by Oyagi, A, Morimoto, N, Hamanaka, J, Ishiguro, M, Tsuruma, K, Shimazawa, M, Hara, H

“…Abstract Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a hypoxia-inducible neuroprotective protein that also stimulates proliferation…”
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Role of metallothioneins 1 and 2 in ocular neovascularization by Nakamura, Shinsuke, Shimazawa, Masamitsu, Inoue, Yuki, Takata, Shinsuke, Ito, Yasushi, Tsuruma, Kazuhiro, Ikeda, Tsunehiko, Honda, Akiko, Satoh, Masahiko, Hara, Hideaki

“…The incidence of blindness is increasing, in part, because of abnormal ocular neovascularization. Anti-VEGF therapies have yielded impressive results; however,…”
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Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia by Wakida, K, Shimazawa, M, Hozumi, I, Satoh, M, Nagase, H, Inuzuka, T, Hara, H

“…Abstract Metallothioneins (MTs) are small cysteine-rich proteins found widely throughout the mammalian body, including the CNS. MT-1 and -2 protect against…”
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Thalidomide protects against ischemic neuronal damage induced by focal cerebral ischemia in mice by Hyakkoku, K, Nakajima, Y, Izuta, H, Shimazawa, M, Yamamoto, T, Shibata, N, Hara, H

“…Abstract We aimed to examine whether thalidomide might inhibit the neuronal damage resulting from focal cerebral ischemia, and if so to explore the…”
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Rifampicin attenuates the MPTP-induced neurotoxicity in mouse brain by Oida, Y., Kitaichi, K., Nakayama, H., Ito, Y., Fujimoto, Y., Shimazawa, M., Nagai, H., Hara, H.

“…Rifampicin, an antibacterial drug, is highly effective in the treatment of tuberculosis and leprosy. Recently, it has been reported to have neuroprotective…”
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Cilostazol reduces ischemic brain damage partly by inducing metallothionein-1 and -2 by Wakida, K., Morimoto, N., Shimazawa, M., Hozumi, I., Nagase, H., Inuzuka, T., Hara, H.

“…The neuroprotective effect of cilostazol, an antiplatelet drug, was examined after 24 h permanent middle cerebral artery (MCA) occlusion in mice, and explored…”
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Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease by Oyagi, A, Oida, Y, Hara, H, Izuta, H, Shimazawa, M, Matsunaga, N, Adachi, T

“…Abstract SUN N8075 is a novel antioxidant with neuroprotective properties. This study was designed to elucidate its neuroprotective effects against 6-hydroxy…”
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Retinal protective effects of topically administered agmatine on ischemic ocular injury caused by transient occlusion of the ophthalmic artery by Hong, S, Hara, H, Shimazawa, M, Hyakkoku, K, Kim, C Y, Seong, G J

“…Agmatine, an endogenous polyamine and putative neuromodulator, is known to have neuroprotective effects on various neurons in the central nervous system. We…”
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A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N-methyl-D-aspartate injection and ischemia-reperfusion by Inokuchi, Y., Shimazawa, M., Nakajima, Y., Komuro, I., Matsuda, T., Baba, A., Araie, M., Kita, S., Iwamoto, T., Hara, H.

“…We investigated the expression of Na+/Ca2+ exchanger (NCX) and the functional role of NCX in retinal damage by using NCX1‐heterozygous deficient mice (NCX1+/−)…”
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P.1.d.008 Diacylglycerol kinase β knockout mice show an abnormal response on psychostimulant-induced behavioural change by Hara, H, Kakefuda, K, Ishisaka, M, Oyagi, A, Tsuruma, K, Shimazawa, M, Yokota, K, Saito, N, Fukunaga, K, Takeda, J

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