Search Results - "Shimada, Keiji"

CXCL1-Mediated Interaction of Cancer Cells with Tumor-Associated Macrophages and Cancer-Associated Fibroblasts Promotes Tumor Progression in Human Bladder Cancer by Miyake, Makito, Hori, Shunta, Morizawa, Yosuke, Tatsumi, Yoshihiro, Nakai, Yasushi, Anai, Satoshi, Torimoto, Kazumasa, Aoki, Katsuya, Tanaka, Nobumichi, Shimada, Keiji, Konishi, Noboru, Toritsuka, Michihiro, Kishimoto, Toshifumi, Rosser, Charles J, Fujimoto, Kiyohide

“…Abstract Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) are reported to be associated with poor prognosis, depending on their…”
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The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study by Ishiba, Hiroshi, Sumida, Yoshio, Tanaka, Saiyu, Yoneda, Masato, Hyogo, Hideyuki, Ono, Masafumi, Fujii, Hideki, Eguchi, Yuichiro, Suzuki, Yasuaki, Yoneda, Masashi, Takahashi, Hirokazu, Nakahara, Takashi, Seko, Yuya, Mori, Kojiro, Kanemasa, Kazuyuki, Shimada, Keiji, Imai, Sunsuke, Imajo, Kento, Kawaguchi, Takumi, Nakajima, Atsushi, Chayama, Kazuaki, Saibara, Toshiji, Shima, Toshihide, Fujimoto, Kazuma, Okanoue, Takeshi, Itoh, Yoshito

“…Background The FIB4 index is clinically useful, but because its formula includes age, the appropriate cutoff point may differ by age group. Here, new FIB4…”
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Phenotypic characterization of adenomyosis occurring at the inner and outer myometrium by Kishi, Yohei, Shimada, Keiji, Fujii, Tomomi, Uchiyama, Tomoko, Yoshimoto, Chiharu, Konishi, Noboru, Ohbayashi, Chiho, Kobayashi, Hiroshi

“…To estimate the phenotypic characterization of fibrotic process in adenomyosis occurring at the inner or the outer myometrium. Eight cases of adenomyosis…”
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MicroRNA-331-3p Suppresses Cervical Cancer Cell Proliferation and E6/E7 Expression by Targeting NRP2 by Fujii, Tomomi, Shimada, Keiji, Asano, Aya, Tatsumi, Yoshihiro, Yamaguchi, Naoko, Yamazaki, Masaharu, Konishi, Noboru

“…Aberrant expression of microRNAs (miRNAs) is involved in the development and progression of various types of cancers. In this study, we investigated the role…”
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Nectin-4 expression contributes to tumor proliferation, angiogenesis and patient prognosis in human pancreatic cancer by Nishiwada, Satoshi, Sho, Masayuki, Yasuda, Satoshi, Shimada, Keiji, Yamato, Ichiro, Akahori, Takahiro, Kinoshita, Shoichi, Nagai, Minako, Konishi, Noboru, Nakajima, Yoshiyuki

“…Nectin-4 belongs to the nectin family that has diverse physiological and pathological functions in humans. Recent studies have also suggested some roles for…”
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Clinical impact of postoperative loss in psoas major muscle and nutrition index after radical cystectomy for patients with urothelial carcinoma of the bladder by Miyake, Makito, Morizawa, Yosuke, Hori, Shunta, Marugami, Nagaaki, Shimada, Keiji, Gotoh, Daisuke, Tatsumi, Yoshihiro, Nakai, Yasushi, Inoue, Takeshi, Anai, Satoshi, Torimoto, Kazumasa, Aoki, Katsuya, Tanaka, Nobumichi, Fujimoto, Kiyohide

“…Although the significance of preoperative nutritional status has been investigated, there is no report regarding the relationship of their postoperative…”
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Diagnostic and prognostic role of urinary collagens in primary human bladder cancer by Miyake, Makito, Morizawa, Yosuke, Hori, Shunta, Tatsumi, Yoshihiro, Onishi, Sayuri, Owari, Takuya, Iida, Kota, Onishi, Kenta, Gotoh, Daisuke, Nakai, Yasushi, Anai, Satoshi, Chihara, Yoshitomo, Torimoto, Kazumasa, Aoki, Katsuya, Tanaka, Nobumichi, Shimada, Keiji, Konishi, Noboru, Fujimoto, Kiyohide

“…Collagen type 4 alpha 1 (COL4A1) and collagen type 13 alpha 1 (COL13A1) produced by urothelial cancer cells support the vital oncogenic property of tumor…”
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MicroRNAs in Smoking-Related Carcinogenesis: Biomarkers, Functions, and Therapy by Fujii, Tomomi, Shimada, Keiji, Nakai, Tokiko, Ohbayashi, Chiho

“…Long-term heavy cigarette smoking is a well-known high-risk factor for carcinogenesis in various organs such as the head and neck, lungs, and urinary bladder…”
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Regulatory T Cells and Tumor-Associated Macrophages in the Tumor Microenvironment in Non-Muscle Invasive Bladder Cancer Treated with Intravesical Bacille Calmette-Guérin: A Long-Term Follow-Up Study of a Japanese Cohort by Miyake, Makito, Tatsumi, Yoshihiro, Gotoh, Daisuke, Ohnishi, Sayuri, Owari, Takuya, Iida, Kota, Ohnishi, Kenta, Hori, Shunta, Morizawa, Yosuke, Itami, Yoshitaka, Nakai, Yasushi, Inoue, Takeshi, Anai, Satoshi, Torimoto, Kazumasa, Aoki, Katsuya, Shimada, Keiji, Konishi, Noboru, Tanaka, Nobumichi, Fujimoto, Kiyohide

“…The clinical significance of regulatory T cells (Treg) and tumor-associated macrophages (TAM) in the tumor microenvironment of human bladder cancer remains…”
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ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals by SHIMADA, Keiji, FUJII, Tomomi, TSUJIKAWA, Kazutake, ANAI, Satoshi, FUJIMOTO, Kiyohide, KONISHI, Noboru

“…The role and function of a novel human AlkB homologue, ALKBH3, in human urothelial carcinoma development were examined. Biologic roles of ALKBH3 were examined…”
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microRNA-145 promotes differentiation in human urothelial carcinoma through down-regulation of syndecan-1 by Fujii, Tomomi, Shimada, Keiji, Tatsumi, Yoshihiro, Hatakeyama, Kinta, Obayashi, Chiho, Fujimoto, Kiyohide, Konishi, Noboru

“…A new molecular marker of carcinoma in the urinary bladder is needed as a diagnostic tool or as a therapeutic target. Potential markers include microRNAs…”
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PCA-1/ALKBH3 Contributes to Pancreatic Cancer by Supporting Apoptotic Resistance and Angiogenesis by YAMATO, Ichiro, SHO, Masayuki, SHIMADA, Keiji, HOTTA, Kiyohiko, UEDA, Yuko, YASUDA, Satoshi, SHIGI, Naoko, KONISHI, Noboru, TSUJIKAWA, Kazutake, NAKAJIMA, Yoshiyuki

“…The PCA-1/ALKBH3 gene implicated in DNA repair is expressed in several human malignancies but its precise contributions to cancer remain mainly unknown. In…”
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Effect of sodium glucose cotransporter 2 inhibitor on liver function tests in Japanese patients with non‐alcoholic fatty liver disease and type 2 diabetes mellitus by Seko, Yuya, Sumida, Yoshio, Tanaka, Saiyu, Mori, Kojiroh, Taketani, Hiroyoshi, Ishiba, Hiroshi, Hara, Tasuku, Okajima, Akira, Umemura, Atsushi, Nishikawa, Taichiro, Yamaguchi, Kanji, Moriguchi, Michihisa, Kanemasa, Kazuyuki, Yasui, Kohichiroh, Imai, Shunsuke, Shimada, Keiji, Itoh, Yoshito

“…Aim No pharmacological therapies have been established for non‐alcoholic fatty liver disease (NAFLD). Sodium glucose cotransporter 2 inhibitor (SGLT2I) was…”
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Diagnostic Strategies for Urologic Cancer Using Expression Analysis of Various Oncogenic Surveillance Molecules—From Non-Coding Small RNAs to Cancer-Specific Proteins by Fujii, Tomomi, Uchiyama, Tomoko, Takeda, Maiko, Shimada, Keiji

“…Urinary-tract-related tumors are prone to simultaneous or heterogeneous multiple tumor development within the primary organ. Urologic tumors have a very high…”
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ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression by Fujii, Tomomi, Shimada, Keiji, Anai, Satoshi, Fujimoto, Kiyohide, Konishi, Noboru

“…The ALKBH family of proteins are highly expressed in various types of human cancer where they are involved in tumor growth and progression. However, multiple…”
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Validation of the risk stratification newly defined in the Japanese Urological Association guidelines 2019 for non‐muscle invasive bladder cancer: A multi‐institutional collaborative study by Miyamoto, Tatsuki, Miyake, Makito, Nakahama, Tomonori, Nishimura, Nobutaka, Onishi, Kenta, Iida, Kouta, Yonemori, Masaya, Enokida, Hideki, Nakagawa, Masayuki, Matsumoto, Hiroaki, Matsuyama, Hideyasu, Matsushita, Yuto, Miyake, Hideaki, Fujii, Tomomi, Shimada, Keiji, Baba, Satoshi, Kinjyo, Mitsuru, Shimokama, Tatsuro, Okumura, Koji, Fujimoto, Kiyohide

“…Objectives To validate the risk stratification newly defined in the Japanese Urological Association guidelines 2019 for non‐muscle invasive bladder cancer and…”
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Keratin 19 as a key molecule in progression of human hepatocellular carcinomas through invasion and angiogenesis by Takano, Masato, Shimada, Keiji, Fujii, Tomomi, Morita, Kohei, Takeda, Maiko, Nakajima, Yoshiyuki, Nonomura, Akitaka, Konishi, Noboru, Obayashi, Chiho

“…Keratin (K) 19-positive hepatocellular carcinoma (HCC) is well known to have a higher malignant potential than K19-negative HCC: However, the molecular…”
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Effect of 12‐week dulaglutide therapy in Japanese patients with biopsy‐proven non‐alcoholic fatty liver disease and type 2 diabetes mellitus by Seko, Yuya, Sumida, Yoshio, Tanaka, Saiyu, Mori, Kojiroh, Taketani, Hiroyoshi, Ishiba, Hiroshi, Hara, Tasuku, Okajima, Akira, Umemura, Atsushi, Nishikawa, Taichiro, Yamaguchi, Kanji, Moriguchi, Michihisa, Kanemasa, Kazuyuki, Yasui, Kohichiroh, Imai, Shunsuke, Shimada, Keiji, Itoh, Yoshito

“…Aims No pharmacological therapies have been established for non‐alcoholic fatty liver disease (NAFLD) with type 2 diabetes mellitus (T2DM). The aim of this…”
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Development of hepatocellular carcinoma in Japanese patients with biopsy‐proven non‐alcoholic fatty liver disease: Association between PNPLA3 genotype and hepatocarcinogenesis/fibrosis progression by Seko, Yuya, Sumida, Yoshio, Tanaka, Saiyu, Mori, Kojiroh, Taketani, Hiroyoshi, Ishiba, Hiroshi, Hara, Tasuku, Okajima, Akira, Umemura, Atsushi, Nishikawa, Taichiro, Yamaguchi, Kanji, Moriguchi, Michihisa, Kanemasa, Kazuyuki, Yasui, Kohichiroh, Imai, Shunsuke, Shimada, Keiji, Itoh, Yoshito

“…Aim Some patients with non‐alcoholic fatty liver disease (NAFLD) develop hepatocellular carcinoma (HCC). Patatin‐like phospholipase domain containing 3…”
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Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition by Park, Sang Yoon, Kim, Hyun Sil, Kim, Nam Hee, Ji, Suena, Cha, So Young, Kang, Jeong Gu, Ota, Ichiro, Shimada, Keiji, Konishi, Noboru, Nam, Hyung Wook, Hong, Soon Won, Yang, Won Ho, Roth, Jürgen, Yook, Jong In, Cho, Jin Won

“…Protein O ‐phosphorylation often occurs reciprocally with O ‐GlcNAc modification and represents a regulatory principle for proteins. O ‐phosphorylation of…”
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