Search Results - "Shim, Seong S"

Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer's disease by Yu, Shan P, Jiang, Michael Q, Shim, Seong S, Pourkhodadad, Soheila, Wei, Ling

“…Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the comorbidity of these brain disorders in aging individuals represents a…”
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Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site by Shim, Seong S, Hammonds, Michael D, Kee, Baik S

“…N-methyl-D-aspartate receptor (NMDAR) hypo-function theory of schizophrenia proposes that impairment in NMDAR function be associated with the pathophysiology…”
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Inhibition of Glycogen Synthase Kinase-3: An Emerging Target in the Treatment of Traumatic Brain Injury by Shim, Seong S, Stutzmann, Grace E

“…Although traumatic brain injury (TBI) has been a major public health concern for decades, the pathophysiological mechanism of TBI is not clearly understood,…”
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Lower Serum Levels of Lithium may Produce Efficacy Without Adverse Effects by Shim, Seong S., M.D., Ph.D

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Lithium Provides Broad Therapeutic Benefits in an Alzheimer's Disease Mouse Model by Wiseman, Alyssa L, Briggs, Clark A, Peritt, Ariel, Kapecki, Nicolas, Peterson, Daniel A, Shim, Seong S, Stutzmann, Grace E

“…Alzheimer's disease (AD) is a chronic neurodegenerative disorder with a progressive loss of cognitive function. Currently, no effective treatment regimen is…”
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Are NMDA receptor antagonists beneficial in the treatment of schizophrenia? by Shim, Seong S, Nadeem, Rashid

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Effects of 4‐week Treatment with Lithium and Olanzapine on Levels of Brain‐derived Neurotrophic Factor, B‐Cell CLL/Lymphoma 2 and Phosphorylated Cyclic Adenosine Monophosphate Response Element‐binding Protein in the Sub‐regions of the Hippocampus by Hammonds, Michael D., Shim, Seong S.

“…:  A large body of evidence indicates that lithium, the prototype mood stabilizer in the treatment of bipolar disorder, has diverse neuroprotective and…”
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Four weeks lithium treatment alters neuronal dendrites in the rat hippocampus by Shim, Seong S., Hammonds, Michael D., Mervis, Ronald F.

“…A large body of evidence from molecular, cellular and human studies suggests that lithium may enhance synaptic plasticity, which may be associated with its…”
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Effects of 4-weeks of treatment with lithium and olanzapine on long-term potentiation in hippocampal area CA1 by Shim, Seong S., Hammonds, Michael D., Tatsuoka, Curtis, Jung Feng, I.

“…► 4 weeks lithium treatment enhanced LTP of hippocampal CA1 pyramides. ► 4 weeks olanzapine treatment did not enhance LTP of hippocampal CA1 pyramides. ► 4…”
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Differential interactions between comorbid anxiety disorders and substance use disorder in rapid cycling bipolar I or II disorder by Gao, Keming, Tolliver, Bryan K, Kemp, David E, Verduin, Marcia L, Ganocy, Stephen J, Bilali, Sarah, Brady, Kathleen T, Shim, Seong S, Findling, Robert L, Calabrese, Joseph R

“…Abstract Objective Anxiety disorders (AD) and substance use disorders (SUD) commonly co-occur with bipolar disorder. This study was undertaken to assess…”
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Effects of sub-chronic lithium treatment on synaptic plasticity in the dentate gyrus of rat hippocampal slices by Shim, Seong S., Hammonds, Micheal D., Ganocy, Stephen J., Calabrese, Joseph R.

“…Although it has long been suggested that lithium has robust neuroplastic actions, and these actions lead to an enhancement on synaptic plasticity, the effects…”
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d -Cycloserine Augmentation for Behavioral Therapy by SHIM, SEONG S., HAMMONDS, MICHAEL D., VRABEL, MATTHEW M.

“…Since the NMDA receptor is crucial in the domains of learning and memory, the Wilhelm et al. study sought to enhance the learning that occurs during behavioral…”
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Effects of Subchronic Lithium Treatment on Levels of BDNF, Bcl‐2 and Phospho‐CREB in the Rat Hippocampus by Hammonds, Michael D., Shim, Seong S., Feng, Pingfu, Calabrese, Joseph R.

“…:  Although it has been proposed that exposure to lithium up‐regulates brain‐derived neurotrophic factor (BDNF), B‐cell leukaemia/lymphoma 2 protein (Bcl‐2)…”
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O1-04-05: Chronic lithium treatment magnifies learning and enhances LTP in area CA1 of the hippocampus by Shim, Seong S, Nocjar, Christine, Hammonds, Michael D

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Action of Atypical Antipsychotics by SHIM, SEONG S.

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P1‐182: LITHIUM SUPPRESSES CALCIUM SIGNALING, NITROSATIVE STRESS AND TAUOPATHY AND ENHANCES SYNAPTIC PLASTICITY IN 3XTG‐AD MICE by Shim, Seong S., Littlefield, Alyssa M., Kapecki, Nicolas, Briggs, Clark, Stutzmann, Grace E.

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LITHIUM SUPPRESSES CALCIUM SIGNALING, NITROSATIVE STRESS AND TAUOPATHY AND ENHANCES SYNAPTIC PLASTICITY IN 3XTG-AD MICE by Shim, Seong S., Littlefield, Alyssa M., Kapecki, Nicolas, Briggs, Clark, Stutzmann, Grace E.

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Lower Serum Levels of Lithium may Produce Efficacy Without Adverse Effects/Authors Respond to Letter by Shim, Seong S, ester, Brent, Moore, Constance

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Brief report: Differential interactions between comorbid anxiety disorders and substance use disorder in rapid cycling bipolar I or II disorder by Gao, Keming, Tolliver, Bryan K, Kemp, David E, Verduin, Marcia L, Stephen, J Ganocy, Bilali, Sarah, Brady, Kathleen T, Shim, Seong S, Findling, Robert L, Calabrese, Joseph R

“…Objective Anxiety disorders (AD) and substance use disorders (SUD) commonly co-occur with bipolar disorder. This study was undertaken to assess AD-SUD-bipolar…”
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Action of atypical antipsychotics / To the editor / Drs. Kapur and Seeman reply by Meltzer, Herbert Y, Shim, Seong S, Kapur, Shitij, Seeman, Philip

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