Search Results - "Shim, Joong‐Youn"

Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids by Lee, Won Jun, Shim, Joong-Youn, Zhu, Bao Ting

“…In the present investigation, we studied the modulating effects of several tea catechins and bioflavonoids on DNA methylation catalyzed by prokaryotic SssI DNA…”
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Quantitative Structure-Activity Relationship of Various Endogenous Estrogen Metabolites for Human Estrogen Receptor α and β Subtypes: Insights into the Structural Determinants Favoring a Differential Subtype Binding by Zhu, Bao Ting, Han, Gui-Zhen, Shim, Joong-Youn, Wen, Yujing, Jiang, Xiang-Rong

“…To search for endogenous estrogens that may have preferential binding affinity for human estrogen receptor (ER) α or β subtype and also to gain insights into…”
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Computational analysis of the CB1 carboxyl-terminus in the receptor-G protein complex by Shim, Joong-Youn, Khurana, Leepakshi, Kendall, Debra A.

“…ABSTRACT Despite the important role of the carboxyl‐terminus (Ct) of the activated brain cannabinoid receptor one (CB1) in the regulation of G protein…”
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Prediction of essential binding domains for the endocannabinoid N-arachidonoylethanolamine (AEA) in the brain cannabinoid CB1 receptor by Shim, Joong-Youn

“…Δ 9 -tetrahydrocannabinol (Δ 9 -THC), the main active ingredient of Cannabis sativa (marijuana), interacts with the human brain cannabinoid (CB1) receptor and…”
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Identification of arsenic-binding proteins in human breast cancer cells by Zhang, Xinyan, Yang, Fan, Shim, Joong-Youn, Kirk, Kenneth L, Anderson, D. Eric, Chen, Xiaoxin

“…Abstract As a cancer chemotherapeutic drug, arsenic acts on numerous intracellular signal transduction pathways in cancer cells. However, its mechanism of…”
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Biochemical and Molecular Modeling Studies of the O-Methylation of Various Endogenous and Exogenous Catechol Substrates Catalyzed by Recombinant Human Soluble and Membrane-Bound Catechol-O-Methyltransferases by Bai, Hyoung-Woo, Shim, Joong-Youn, Yu, Jina, Zhu, Bao Ting

“…Catechol-O-methyltransferase (COMT, EC 2.1.1.6) catalyzes the O-methylation of a wide array of catechol-containing substrates using s-adenosyl-l-methionine as…”
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Homology model of the CB1 cannabinoid receptor: Sites critical for nonclassical cannabinoid agonist interaction by Shim, Joong-Youn, Welsh, William J., Howlett, Allyn C.

“…Association of cannabimimetic compounds such as cannabinoids, aminoalkylindoles (AAIs), and arachidonylethanolamide (anandamide) with the brain cannabinoid…”
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Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1) by Ahn, Kwang H., Mahmoud, Mariam M., Shim, Joong-Youn, Kendall, Debra A.

“…The cannabinoid receptor 1 (CB1) is a G protein-coupled receptor primarily expressed in brain tissue that has been implicated in several disease states. CB1…”
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WIN55212-2 Docking to the CB1 Cannabinoid Receptor and Multiple Pathways for Conformational Induction by Shim, Joong-Youn, Howlett, Allyn C

“…Key pharmacophoric elements for the (aminoalkyl)indole (AAI) CB1 cannabinoid receptor agonists are the aminoalkyl moiety, the lipophilic aroyl group, and the…”
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Transmembrane Helical Domain of the Cannabinoid CB1 Receptor by Shim, Joong-Youn

“…Brain cannabinoid (CB1) receptors are G-protein coupled receptors and belong to the rhodopsin-like subfamily. A homology model of the inactive state of the CB1…”
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Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro by Takemura, Hitomi, Shim, Joong-Youn, Sayama, Kazutoshi, Tsubura, Airo, Zhu, Bao Ting, Shimoi, Kayoko

“…In the present study, we compared the estrogenic activity of zearalenone (ZEN) and zeranol (ZOL) by determining their relative receptor binding affinities for…”
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Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαiβγ: identification of key CB1 contacts with the C-terminal helix α5 of Gαi by Shim, Joong-Youn, Ahn, Kwang H, Kendall, Debra A

“…The cannabinoid (CB1) receptor is a member of the rhodopsin-like G protein-coupled receptor superfamily. The human CB1 receptor, which is among the most…”
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Identification of essential cannabinoid-binding domains: structural insights into early dynamic events in receptor activation by Shim, Joong-Youn, Bertalovitz, Alexander C, Kendall, Debra A

“…The classical cannabinoid agonist HU210, a structural analog of (-)-Δ(9)-tetrahydrocannabinol, binds to brain cannabinoid (CB1) receptors and activates signal…”
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Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced Hamster Cheek Pouch Carcinogenesis by a 5-Lipoxygenase Inhibitor, Garcinol by Chen, Xin, Zhang, Xinyan, Lu, Ye, Shim, Joong-Youn, Sang, Shengmin, Sun, Zheng, Chen, Xiaoxin

“…Our previous studies have shown that aberrant arachidonic acid metabolism, especially the 5-lipoxygenase (5-Lox) pathway, is involved in oral carcinogenesis…”
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A model for the unique role of factor Va A2 domain extension in the human ternary thrombin-generating complex by Shim, Joong-Youn, Lee, Chang Jun, Wu, Sangwook, Pedersen, Lee G.

“…An all-atom human ternary model for the prothrombinase–prothrombin complex, including metal ions and post-translationally modified residues, was constructed…”
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Probing the Interaction of SR141716A with the CB1 Receptor by Shim, Joong-Youn, Bertalovitz, Alexander C., Kendall, Debra A.

“…SR141716A binds selectively to the brain cannabinoid (CB1) receptor and exhibits a potent inverse agonist/antagonist activity. Although SR141716A, also known…”
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Do the crystallographic forms of prethrombin-2 revert to a single form in solution? by Wu, Sangwook, Shim, Joong-Youn, Lee, Chang Jun, Pedersen, Lee G.

“…It has been earlier established (Pozzi et al. Biochemistry 50 (2011) 10195–10202) that prethrombin-2 crystallizes into two similar but distinct forms: a…”
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Three-Dimensional Quantitative Structure−Activity Relationship Study of the Cannabimimetic (Aminoalkyl)indoles Using Comparative Molecular Field Analysis by Shim, Joong-Youn, Collantes, Elizabeth R, Welsh, William J, Subramaniam, Babu, Howlett, Allyn C, Eissenstat, Michael A, Ward, Susan J

“…The present study describes the implementation of comparative molecular field analysis (CoMFA) to develop two 3D-QSAR (quantitative structure-activity…”
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Distinct second extracellular loop structures of the brain cannabinoid CB 1 receptor: Implication in ligand binding and receptor function by Shim, Joong‐Youn, Rudd, James, Ding, Tomas T.

“…Abstract The G‐protein‐coupled receptor (GPCR) second extracellular loop (E2) is known to play an important role in receptor structure and function. The brain…”
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Distinct second extracellular loop structures of the brain cannabinoid CB1 receptor: Implication in ligand binding and receptor function by Shim, Joong-Youn, Rudd, James, Ding, Tomas T.

“…The G‐protein‐coupled receptor (GPCR) second extracellular loop (E2) is known to play an important role in receptor structure and function. The brain…”
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